Basic Information

Insect: Timandra comae
Gene Symbol: topi
Assembly: GCA_958496195.1
Location: OY292371.1:6302176-6308309[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 0.00038 0.034 15.2 1.2 1 23 291 313 291 313 0.98

2 12 0.0002 0.018 16.1 0.2 2 23 321 342 320 342 0.95

3 12 0.045 4.1 8.7 0.5 1 23 346 368 346 368 0.97

4 12 0.00037 0.033 15.3 0.5 1 23 373 396 373 396 0.98

5 12 0.00073 0.065 14.3 0.4 1 23 400 423 400 423 0.94

6 12 0.0027 0.25 12.5 0.3 2 21 438 457 437 462 0.92

7 12 0.0057 0.51 11.5 3.7 3 23 472 493 472 493 0.98

8 12 0.19 17 6.7 0.6 3 23 514 535 512 535 0.95

9 12 1.9e-06 0.00017 22.5 0.8 1 23 546 568 546 568 0.99

10 12 5.8e-06 0.00052 20.9 0.8 1 23 574 596 574 596 0.96

11 12 0.0003 0.027 15.5 3.5 1 23 602 624 602 624 0.96

12 12 1.1e-05 0.001 20.0 0.5 1 23 630 653 630 653 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	0.00038	0.034	15.2	1.2	1	23	291	313	291	313	0.98
2	12	0.0002	0.018	16.1	0.2	2	23	321	342	320	342	0.95
3	12	0.045	4.1	8.7	0.5	1	23	346	368	346	368	0.97
4	12	0.00037	0.033	15.3	0.5	1	23	373	396	373	396	0.98
5	12	0.00073	0.065	14.3	0.4	1	23	400	423	400	423	0.94
6	12	0.0027	0.25	12.5	0.3	2	21	438	457	437	462	0.92
7	12	0.0057	0.51	11.5	3.7	3	23	472	493	472	493	0.98
8	12	0.19	17	6.7	0.6	3	23	514	535	512	535	0.95
9	12	1.9e-06	0.00017	22.5	0.8	1	23	546	568	546	568	0.99
10	12	5.8e-06	0.00052	20.9	0.8	1	23	574	596	574	596	0.96
11	12	0.0003	0.027	15.5	3.5	1	23	602	624	602	624	0.96
12	12	1.1e-05	0.001	20.0	0.5	1	23	630	653	630	653	0.98

Sequence Information

Coding Sequence: atgagttTCTTGTTTGATCCAAGTGTAATTGATAATCCGATGATTTGTAGAGTATGTTTGGTAACAGATGTGAAGATGGATAGCTTGCACCTTACTGCTCTGCAGACTAGTTTTGAAGCTTTATGTGGAATACCTGTATTAAGTACTTCAGAACTACCAATGTTCCTGTGCTATGAGTGTGTATCATATGTGAAGAAGTTCTCGTTGTTTAAAAACAGATGTCTCCGGGGGCAAGATGTGTTATATGGTATACTGAACAGTAGCGGACagaTAACAGAACAAGCAGTAAAGAATATAGACAGACAAAAACTACATCTCACATCAAACATTTCAATACACCACATCAACAAACAAGATTTACCATTTAacatagaatattttatagaaactGATGATAtacctaaaataaaagtagaaCCAGTTTTAGAAAATGGTGTCAGTGAAACAGTTGATCTAGATAGTTTAAAAGAAGAAGATGACTTCCCAGACTTAGGAATCTCTAGCGACGATGAACCATTGTCTATGCATAAGAGTaaagataaaagaaaaaagaagaaaagtaGGAAAAAGAAAGAGTTGATAGAAGTATCTGtaaattttgattctaatgatCAGTTTGAGGAAATAAAAGAAAACGAAGTTATCGAAGATCCCGAAACAGAGACTGCAAAACGTAAACGCGGTCGCCCGAAGAAATCAGGAGAAATAGTCCCCAAACAACCGAAACTCAGAAGGACCAAGAACACGGGAGGAGTTTATCCGGATGATATCAATTTGGATGAATTTGTCGATATTATTACACTTTCTTTGGAAGAGCAATTGGAAGAGATAAACAAGCGCAAAGATTCTGATAACTATTTGAACGCACTGTACCAGTGTAACTTGTGTTATAAAggatttatagacaataaggCGTGGCAACACCATATTGGGAAACATGATGCAaaagcCGGCGATGTAGAATGTCCAGTCTGCAAGTTTAGATTTGTAAATAAGCGAGCACTACAGAAGCATGCCATTAATCACGAGAAGAAATATGCCTGCAAAGCATGTCCCTATGTTTCTAAGACTACAACGCAAGCAAAACAACATCAACGATGGCATAAAGGCGTAACATACACATGCGAATATTGTGATGAAGTCTCTACgaAATGGACGTCATATTTGTCCCACGTCCGCATCAAACATCCGTCGAATCACGTTTGTGGAATTTGCGGGTACTCGTTCGTCAGTTCACTCGGGTTAACAATGCATAAGACCATGATGCATAAGGATGttaagGAGACGGACGTGGGTAACGAGTCTTGGTCGTACTGTCAAGAGTGTGACGTGAAGTTTATATCATTGGAAGCGTACAAACGGCATATGGTTACTTCAGTGAAACATTCCGAGAGTAAAAACTTCAGCCGTGGTTGTCGCGTATGCGGGTGTACGTTTGCCTCGACCGAAGAGCTTCGCCTACATCACCGACGGGAacacgcgcgccgccgccctaAGAACTACGGCAGGAAACCCGCCGGCAACTCGTGGCCTATTAACTGTCAACACTGTAACGAGGAAATAGAGAACGCTCGGGAGTACTGGACACATTTCCGGCGCGCTCACCCCGACCTGCCTTACCCGATACAGAAGAATTACGTCTGTGATATCTGTGGAAAGAGCTTTAGGGGCAACGCATTCCTGACATACCACAAGCGCACGCACTCGGAGGAGCGTCCGTTCGCGTGCGGCGCGTGCGGCAAGGCGTTCCACAACCGGTCCAACCTCAACCTGCACGTGCGCACGCACTCCGACCTGCGCCCGCACGCCTGCGACGTCTGCGGCAAGGGCTTCAAGTGCAAGTCCGCGCTCGACCGCCACTACCGGACTCACACAGGAACAAAACCTTACCAGTGCGAAGTGTGTGGCAAGTCGTTCGGCCAGTCGAACAGTCGTAAGTTACACGTCCGGACAGTGCATCTCAAACAACCGGCGCCTTTCGTCAGTCGCAGTCGGCAGGAGCGGAGGAAGATGCAGAAGGAACAGGTCACATTGCCTTTTGTTTATTAG
Protein Sequence: MSFLFDPSVIDNPMICRVCLVTDVKMDSLHLTALQTSFEALCGIPVLSTSELPMFLCYECVSYVKKFSLFKNRCLRGQDVLYGILNSSGQITEQAVKNIDRQKLHLTSNISIHHINKQDLPFNIEYFIETDDIPKIKVEPVLENGVSETVDLDSLKEEDDFPDLGISSDDEPLSMHKSKDKRKKKKSRKKKELIEVSVNFDSNDQFEEIKENEVIEDPETETAKRKRGRPKKSGEIVPKQPKLRRTKNTGGVYPDDINLDEFVDIITLSLEEQLEEINKRKDSDNYLNALYQCNLCYKGFIDNKAWQHHIGKHDAKAGDVECPVCKFRFVNKRALQKHAINHEKKYACKACPYVSKTTTQAKQHQRWHKGVTYTCEYCDEVSTKWTSYLSHVRIKHPSNHVCGICGYSFVSSLGLTMHKTMMHKDVKETDVGNESWSYCQECDVKFISLEAYKRHMVTSVKHSESKNFSRGCRVCGCTFASTEELRLHHRREHARRRPKNYGRKPAGNSWPINCQHCNEEIENAREYWTHFRRAHPDLPYPIQKNYVCDICGKSFRGNAFLTYHKRTHSEERPFACGACGKAFHNRSNLNLHVRTHSDLRPHACDVCGKGFKCKSALDRHYRTHTGTKPYQCEVCGKSFGQSNSRKLHVRTVHLKQPAPFVSRSRQERRKMQKEQVTLPFVY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -