Basic Information

Gene Symbol
ZEB2
Assembly
GCA_905147785.1
Location
LR990495.1:9659624-9671850[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 3.2 2.4e+02 3.0 0.3 2 23 6 27 5 27 0.95
2 13 0.00014 0.011 16.7 0.4 1 23 1004 1026 1004 1026 0.94
3 13 1.6e-05 0.0012 19.6 1.7 2 23 1129 1150 1128 1150 0.97
4 13 0.00017 0.013 16.4 2.5 1 23 1156 1178 1156 1178 0.98
5 13 0.0077 0.58 11.2 2.5 2 23 1185 1206 1184 1207 0.95
6 13 1.1 80 4.5 2.9 5 23 1220 1238 1219 1238 0.96
7 13 0.0076 0.57 11.2 1.7 3 23 1245 1266 1244 1266 0.96
8 13 0.0058 0.43 11.6 0.1 2 23 1285 1305 1284 1305 0.97
9 13 0.0037 0.28 12.2 0.6 3 20 1313 1330 1311 1333 0.85
10 13 0.00092 0.069 14.1 0.4 1 23 1341 1363 1341 1363 0.98
11 13 0.0055 0.41 11.7 7.2 1 23 1369 1391 1369 1391 0.98
12 13 7.5e-06 0.00056 20.7 1.4 1 23 1397 1421 1397 1421 0.98
13 13 0.001 0.075 14.0 5.1 1 23 1427 1449 1427 1450 0.95

Sequence Information

Coding Sequence
ATGGATCATCTTGTACAGTGCCCCGTTTGTACACTCTACCTCCACAATGGGATGTCTCTGGAGTCGCATCTCGACACGCATCCCAAAGATCAAGTTATCAAAGCACTGTGCTGCCTTACAGCCAAGAGCAGCACCTATGGAAGTAGAACATCCACCCCCCTCAATTCGGAAAGGTCATTCAGGAGCAGGTCACGGACACCGGCAACAGATGACAGTGCACGGTGGACAAGTTCCCACCGGAGCGCTGAGCATGACAGATACTGGCGTAGAACACCAAGTAGGACACCCAGTAGAACACCAAGTAGAACTCCTAAAACAACACCAGTGACAAATGTATCAAGGAATGCCACCCCAGACACAAGAATGGCAGATATTAACTATGATAACTCTGTCACAAATTCTGATCCACATTCTGGCCCCCCTTTTGTCATGAAAACTGATAAGACACAGCAAACGTTCCAACAGGCACCTCCACACTCAGATTTTGATCCACAGTATATTTATTTCCAAGATCAACAGGATGAAATTAAATACTCACGCAGTGCTGAATATAATGCATTGGATACCAATAACCTTTTTGCCTACAACATGCCTCCTGCGGGGGCTGGGATGAAACTGCAGACAGCTTTGATGCCCACTGTACCTAGGAGACCTAATGACCTTGTAAAAATTTTGCCAAAACCTAATAACATACTTGTCAAAGCTAATATGGGTGGTATGCAATATCTTACTCCTGGAGTGAAACCTATGCATGTAGTGATGCCACCAACACCGGCATTTGTTCAGAAAAATATGCAGAATAACTTGATAATGGCTAATTTACCATCTGTTCCAATGCATATTGATGGTAAAAGTATCTCTCAACAGAAAGCAAATCAGTTCAATCATTTAACGTCAGGTAGCTTCACACCCAGCACGACAGTTGTCACTCAGAACTCGCAGATTATTTACAGGGAAATGGTACACAATTTAGATGGGAAGCCTTTTATTTCTAGCATGCCAACTGTACTCGGGGGTCACGAGAATGTCACAAATGTCGCGCAAGCCAGCTCCATGTATCAAAATGTAATGGTAGTGGATCAGTTTGGGAACACGTCTTGTATGTTTACGACACCACAGCAACTAATGCCCAAGTCTTGTCCCCCACCTATATACAATAACCCACCTATATCAGTTGGTATTGGTGCGCAATTAGATAAGACTGTGCCAAACACAAGTGATAGCAATAAAACTCTTATGATCAAAGTCAGCCCCATAGTGCCCTCGGAGCCCGTAGTTAAAGCATCAACCACTAGTTCACTTCCAGAAAGTGGCTCGTCAAGGGAAAAAAAAGAGAAATCTACTAAAAAGGTTGAACCTAAGTGTGATATCCCAGGAACTAGTAAAGGTCTTAAAATTCTAAGTAATATAAAAGTAGAAGTCCCCGTACAGCATCATAAGAACATGGTTAATACAGTGATGGATCTTACTTGCTCAAATGACCCCGATTATCCAGAGCCCTCTGATACACCAGAGAAGATCCTACCGGACTTAGACGATAATAAGACTATCATATCAGATGATTGTACTCAACCCTCAATATCAAGCAGTGATAGCATAGTCTCTCATACATTCTCTGTGATAAAAAATGTTGGTAACCCACCCTCGTACAAAGATACTTCCAATAAATCAAATATTCTAGATAATAAGATTGAAACTGAGTTTACAGATAGTTGTCCTGTGCCAGATCTAATATGCAATGAGAAGCCTTCAATATCACCTTGTAGCGAGTTGTCTGAACAGTGTGACAACTCGACCGATCGCACCCTAATATCACCTAAGCCCGAAAACAGTCGTCCATCACAAAACGCCCTAGACATTCACATCGAGAAGAAGGTTCAATTCCCAACAAAGCCATTTAGGAACAACACTTTAAGACTGAACAATATTTACGTGAAGAAGAACAAAAAAGTTTTGCAGATAAAGAATGCCAAGTCATCTAGCTTGAGTAGTTCCAGCAAGTCAGAAACGGAGCCTATACCGTCGTCGTCGATTTGTAGGTCGCCAGAAAGTTTTAGCATGAATAAAAAACAAAAGACAGAAAGAAATGAGAGTAGGGACAAGTGCAGTGTTCTACAAACGGTATCAATCGAAATGGTGAAGGAGAACGATGAGCCTAACGACTTTGATGCTGACACTGAAGAGCAGTCTATGGATATCGAGCCGATTGCCACGTCTAATATCAATCATTCCAACGAATACGGGACGTCTGTCGACATGGTACATGTAAAAGAGGAGGTGAACTCGAGCAACGAAGGGGCATTCAGCAACGAGACCACTAGCCGTGTCCTAACACCACTGGAAACCCTTCGCCCCATAAACGTGATCACCTACGGTAGCATGTCCGCCGGCGACTTTGAAGACGAATCCAACCATAGGGAACTTCTCGACCTGGAAGCGGCATCGAAAAACAAGCAGTTCGTAAACATGATGAACGAAAACTATTTCGGCGATAATATCTATGCTGATTATTTTACACCCGACCGCGTGGAGTCTTTCGACGCAGAACGAGAGAGTTCGGCGTTTAAGGAGGGTTCTATAGGAATATGGGGGGAGCCATCACAGAAAGAAGAAAACGAATTTGTGCTGCCGAACTTCATTCACGAGAGCTACAAGATAGCTGAGAGTACAGGATTAGATTACTCCGATATGGGTGGTAGAGAAGGACAGGTGGATGTGGAGGGGGAGGGGTGCGAGAGGGACAGCAAGGTGGACGTGCTGAGTGAGGGGGAACCACCGCTGAACATCTGTGCGGATGAGCGGATGCCGCCGCGAGGGGAGCTCAGCGGTCAGGAGAGCAACGGTGATATGGAGTCTTGGAACGGGATGTATTCGGAGGTGACCCCGGCGGCGCCCTACGACCTGATGGCGCGCGAGAGCTGGGTCTCAGACGACTCCGAAATGGATGCCACAGAGAAACGGGAAGCATTAGAGGAAGAGCTACACTTCCCAAAGAGTACGCACAGACAGTACACGTGTACGCAGTGCGGGGCAAAGTTCACCTCGCTCAAGGAGCTGCGCGCGCACAGGGTGGCTCATGCGGCGACCGCCACCTCACCCGCCAAGACCTCCTACAGCCGCCTCGTCACCGCCAGGACTATAAAGAAGGAAGAGAAACCTGATGCCGCCATGTTGACTAGCAACCTCCTCGCAATAGATTCAAAAGAATCCATAACGTCGACCATCCTCCAAGTGTACGACACGATAGCCGAAGCCAAGCCGAAGATCGAGGTCCTGATCAAGCAGGAGACGAAACGGCGGCGGAAGGACTACGTGTGCCCCACTTGCAAGGTGGACCAAGTGTCTGATGCAGCCTTCCACGCTCATCTCAAGATCCATCCCCTGGAGTGTCTCACGTGTGGGAAGTGCTTCTTCAGGAGAGCGAACTTGGCGCTACACATCAAGACGCATTTAGGGATCAAGAATTATAAATGCGACGTGTGCGAGAAAAGGTTTATAACCCGGCAGAAGTTGATGGAGCACCACAACGTGCACACCGGCCGCGCGCCCGTCAAGTGCACCGTGTGCGACGACACCTTCCGCCGCTACTCCAACATGGTGCAGCACAGGGACCGTCACCACCACGCCAAGCGAGCTAAAGTCCGAGACTACGTGTGCCAATGCGGGGCCGTGTTCCACTCTCGTGCTAAACTCCACTGGCATAGAGAGACTCATGACGGCCGCCCCAAGGCTTGCCTCTACTGCAGCGACAAGTTCGTCCACGCCTCGTCCCTCACTAGGCACGTGAGGCGTACCCACAATGAGTACTTCCTGTCTGACAGGGTGAGGGGTTCCCTGGCTGGGGAGAATGTGCCGTGTCCCGTATGCAAACAGATATACCTCAGGTCGAACCTCCGCGCCCACCTCCAAACGCACAGCGGCAAGCGTCCCTACCTCTGCATCATTTGCAACAAGGCGTTTACAACCAAATGGAATCTTAAACTCCACAGGTGGACCCACATGAACCGCTCAGCGAAACCGTTCAAATGTAACTTATGCAAAGGTGCCTTCATACGACAAACTGAGTATATATCCCACATGAACGCGCACAAATCCGTGCGTCCTTACACGTGCAATTACTGCGGCTGTCAATTCATTAGGAAGTATAATTGCCAACGACACGTCAGGGAACACGAAATGGACAAGAAGTACGTGTGCAAAGTGCCAGAGTGCGGTAAGACCTTCCACAGGAGTTATTATTTGTCCGAACACATGAAGGTACATAGCGGCGCTAGGCCGTTCTCGTGCAATATATGCGGCAAAACTTCAAGTAATAAGTCTAATCATAATAAACACGTGAAGATACATCACGCGCGGGAACCGGTCGCCACGGAGGCGTAG
Protein Sequence
MDHLVQCPVCTLYLHNGMSLESHLDTHPKDQVIKALCCLTAKSSTYGSRTSTPLNSERSFRSRSRTPATDDSARWTSSHRSAEHDRYWRRTPSRTPSRTPSRTPKTTPVTNVSRNATPDTRMADINYDNSVTNSDPHSGPPFVMKTDKTQQTFQQAPPHSDFDPQYIYFQDQQDEIKYSRSAEYNALDTNNLFAYNMPPAGAGMKLQTALMPTVPRRPNDLVKILPKPNNILVKANMGGMQYLTPGVKPMHVVMPPTPAFVQKNMQNNLIMANLPSVPMHIDGKSISQQKANQFNHLTSGSFTPSTTVVTQNSQIIYREMVHNLDGKPFISSMPTVLGGHENVTNVAQASSMYQNVMVVDQFGNTSCMFTTPQQLMPKSCPPPIYNNPPISVGIGAQLDKTVPNTSDSNKTLMIKVSPIVPSEPVVKASTTSSLPESGSSREKKEKSTKKVEPKCDIPGTSKGLKILSNIKVEVPVQHHKNMVNTVMDLTCSNDPDYPEPSDTPEKILPDLDDNKTIISDDCTQPSISSSDSIVSHTFSVIKNVGNPPSYKDTSNKSNILDNKIETEFTDSCPVPDLICNEKPSISPCSELSEQCDNSTDRTLISPKPENSRPSQNALDIHIEKKVQFPTKPFRNNTLRLNNIYVKKNKKVLQIKNAKSSSLSSSSKSETEPIPSSSICRSPESFSMNKKQKTERNESRDKCSVLQTVSIEMVKENDEPNDFDADTEEQSMDIEPIATSNINHSNEYGTSVDMVHVKEEVNSSNEGAFSNETTSRVLTPLETLRPINVITYGSMSAGDFEDESNHRELLDLEAASKNKQFVNMMNENYFGDNIYADYFTPDRVESFDAERESSAFKEGSIGIWGEPSQKEENEFVLPNFIHESYKIAESTGLDYSDMGGREGQVDVEGEGCERDSKVDVLSEGEPPLNICADERMPPRGELSGQESNGDMESWNGMYSEVTPAAPYDLMARESWVSDDSEMDATEKREALEEELHFPKSTHRQYTCTQCGAKFTSLKELRAHRVAHAATATSPAKTSYSRLVTARTIKKEEKPDAAMLTSNLLAIDSKESITSTILQVYDTIAEAKPKIEVLIKQETKRRRKDYVCPTCKVDQVSDAAFHAHLKIHPLECLTCGKCFFRRANLALHIKTHLGIKNYKCDVCEKRFITRQKLMEHHNVHTGRAPVKCTVCDDTFRRYSNMVQHRDRHHHAKRAKVRDYVCQCGAVFHSRAKLHWHRETHDGRPKACLYCSDKFVHASSLTRHVRRTHNEYFLSDRVRGSLAGENVPCPVCKQIYLRSNLRAHLQTHSGKRPYLCIICNKAFTTKWNLKLHRWTHMNRSAKPFKCNLCKGAFIRQTEYISHMNAHKSVRPYTCNYCGCQFIRKYNCQRHVREHEMDKKYVCKVPECGKTFHRSYYLSEHMKVHSGARPFSCNICGKTSSNKSNHNKHVKIHHAREPVATEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00761984;
90% Identity
-
80% Identity
-