Basic Information

Gene Symbol
-
Assembly
GCA_948477245.1
Location
OX419740.1:10517724-10537197[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.096 9.6 7.8 0.2 3 20 8 26 6 28 0.85
2 12 0.19 19 6.9 0.2 1 12 204 215 204 218 0.93
3 12 7.6 7.6e+02 1.9 0.1 1 19 341 359 341 359 0.94
4 12 8.9e-06 0.00089 20.5 0.4 1 23 366 388 366 388 0.99
5 12 1.8e-05 0.0018 19.6 3.0 1 23 404 426 404 426 0.98
6 12 0.0005 0.051 15.0 0.9 3 23 480 500 478 500 0.97
7 12 0.00042 0.042 15.3 2.8 1 23 516 538 516 538 0.99
8 12 3.2e-06 0.00032 21.9 4.2 1 23 544 566 544 566 0.98
9 12 0.00068 0.069 14.6 5.6 1 23 572 594 572 594 0.98
10 12 9e-06 0.00091 20.5 0.4 1 23 600 622 600 622 0.98
11 12 0.00079 0.079 14.4 0.3 1 23 626 648 626 648 0.98
12 12 0.0013 0.13 13.8 0.1 1 23 656 679 656 679 0.96

Sequence Information

Coding Sequence
ATGGAGGGTCAACAAATAGTTTGTCCTCTGTGTTGTGATAAAACTTTTGACTCTAAACAGGCACTGGTGGAACATTTATCTAATATTTTGAATAATATATTTTGTCCACTTTGCAAAAGCAAGTGGAACTCATTGCAAGAACTTAACGAGCATTTAACTGATTTTAACTGCGTCTCTATACAAAATGATCCTGTACAAAATATTGTTATTTATGAACAAGAACTGCATGTACACAATGATAATTCAACACTTGCAAAAGAGCCTATTTCACCTGAACTAAGCACAACAGACACACAATATATTACTGATGAAACATATGATAACCAAGATGATAAGAATGAAGTTAATAATATGTATGTCGAACTACTCAGTAAACAACTGTCTAAGCCTGTAATTCAAACACAAGAGTTGAAGTTAATAAAGGAAGATGGAGAAAATCGTTATGTGCTTGTGACCCAAGATGAAATGGAACTAATTGAGAACAATGCAATTGTTACAAAACAAAACAATGATGGCAGTATATCTCTTACTACTGTTAATGATATGAAATTGGAAATGGATACTCTTATAGTTTCACAGCCTGCTCCTCAGCACAAAGAAAATGAATTATATAGCTGCAATACTTGTGGGGTGTCGTTTACGTCGGTGCTTGAACACATACAGAACTACCATAATGATCAGGAAGTCGTTCTTGAGGAAGGTGATGAAGAATCAACAATAACGGACAAACAAGCTGCAAGGCGAGTTATTACAGATACCGGTGATATTGTAGAGGAGCCAATGGTTTTTAAAGCTGAGGACACTGAAATTGAGCACACTATAGATGCAATGGTAAAGCAACCTGAATTTGTGCTGGATAAGCATGGCCACGCTTACACTAAACGCCTTGTTGAAAACGACATAATATCTGAGACTGTTAGCAACGAGGCTACGACAGTTCAACCTGTTCCAGAAAAAATTGACTACCACAAAGTAATCAAGAAACAAGTTCAGATGAAGACTGGTCTGACAGTTAAAATGTACAACTGCATGACTTGCAATGTAACGGTCGCTGATTTGAATGAATTTGAATCACATCCATGTAAAACTTTTAAATACCAATGTCCTCATTGTCCAGTTGGTTACGAAACCTCAAAGTCTTTATCGGCACATATGAAAGTACACAAGGACCGATCAGAAGGAGGTCCCGTGTTAATGCTGCCTTCGACCTATGTATGTGGAGTGTGCCACACTGTTTTCAAAACTAACAAGTCTTTAAAACTACACAAGCGAATGCACGATCCAATCAAATCGCGTCCTATCGAGCCTCCAGTGGAAAATTTCGACGGTAAAGACGTGACCGGCGAAGTATTCCTGTGCACCACGTGCAACAAAATGATCCCTCTGGACTATCGTTCCGTACATGAGGACTCTCACTACACCACAAACAAAATGAATTGTAGTATATGCAACAAGAAGTTTACCTCCATGGAGTTTATGGAGATGCATATGAACATACATAATTTAGATAAAGCGCCCATGAACAAACAAGACAAGTCACTTCCTTACAAATGTTTATACTGCAACAGGAGGTTTGCGAGGCCACACGAAAAGGTTAAACACGAAAGGATTCATACCGGTGAGAAGCCGCACTCGTGTGAGATCTGCGGCAAGTCATTCCGCGTACTGTACTGCCTTACACTGCACATGCGGACACATACTGGAGCACGGCCCTACGAGTGTCCACACTGCGGGAAGAGGTTCAAAGCACACAGCGTATACAGCCACCATCTACTTACGCACTCCGAAGTTCGTGCTTATAAGTGTCCGTTCTGTCCGAAAGCTTTCAAGACGTCGGTGCAACTTGCTGGACACAAGAATTCACACACCAAGCCGTTCTCGTGTCAACAATGTAATAGGCCGTTCGCATCTCTTTACGCGGTCCGCGTTCACACCGAGACGCACAACCGACAGAACAATCTGAAGTTCTCGTGCGCGATGTGTGGCGCGAGTTACGCGCGAGCTTTCGCGCTCAAAGACCACGTCAAGCAGGTGCATAACAAGGACCTGGACACTGCCGAAAACATCGTCGAGAATAATCCAGAGGACAATGATGACTGGATAGTGGGAGATTCCACCACCATTGACCCAGATGGGATGCCATCACCCAGTAACGATCTACAAGAAACGATGACGGATTTGGAAATGACTGCCAACGAATTAATAGTTCCTTAA
Protein Sequence
MEGQQIVCPLCCDKTFDSKQALVEHLSNILNNIFCPLCKSKWNSLQELNEHLTDFNCVSIQNDPVQNIVIYEQELHVHNDNSTLAKEPISPELSTTDTQYITDETYDNQDDKNEVNNMYVELLSKQLSKPVIQTQELKLIKEDGENRYVLVTQDEMELIENNAIVTKQNNDGSISLTTVNDMKLEMDTLIVSQPAPQHKENELYSCNTCGVSFTSVLEHIQNYHNDQEVVLEEGDEESTITDKQAARRVITDTGDIVEEPMVFKAEDTEIEHTIDAMVKQPEFVLDKHGHAYTKRLVENDIISETVSNEATTVQPVPEKIDYHKVIKKQVQMKTGLTVKMYNCMTCNVTVADLNEFESHPCKTFKYQCPHCPVGYETSKSLSAHMKVHKDRSEGGPVLMLPSTYVCGVCHTVFKTNKSLKLHKRMHDPIKSRPIEPPVENFDGKDVTGEVFLCTTCNKMIPLDYRSVHEDSHYTTNKMNCSICNKKFTSMEFMEMHMNIHNLDKAPMNKQDKSLPYKCLYCNRRFARPHEKVKHERIHTGEKPHSCEICGKSFRVLYCLTLHMRTHTGARPYECPHCGKRFKAHSVYSHHLLTHSEVRAYKCPFCPKAFKTSVQLAGHKNSHTKPFSCQQCNRPFASLYAVRVHTETHNRQNNLKFSCAMCGASYARAFALKDHVKQVHNKDLDTAENIVENNPEDNDDWIVGDSTTIDPDGMPSPSNDLQETMTDLEMTANELIVP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-