Tjap013836.2


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Theretra japonica
Gene Symbol
Hnf4
Assembly
GCA_033459515.1
Location
CM065945.1:4519030-4537233[-]

Transcription Factor Domain

TF Family
RXR-like
Domain
zf-C4|RXR-like
PFAM
AnimalTFDB
TF Group
Zinc-Coordinating Group
Description
DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 33 4e-63 1.3e-59 201.7 0.0 1 197 211 404 211 407 0.94
2 33 4.9e-09 1.5e-05 25.2 0.0 159 197 411 449 404 452 0.90
3 33 4.6e-09 1.5e-05 25.2 0.0 159 197 456 494 449 499 0.90
4 33 4.9e-09 1.5e-05 25.2 0.0 159 197 501 539 494 542 0.90
5 33 4.9e-09 1.5e-05 25.2 0.0 159 197 546 584 539 587 0.90
6 33 4.6e-09 1.5e-05 25.2 0.0 159 197 591 629 584 634 0.90
7 33 4.9e-09 1.5e-05 25.2 0.0 159 197 636 674 629 677 0.90
8 33 4.9e-09 1.5e-05 25.2 0.0 159 197 681 719 674 722 0.90
9 33 5.2e-09 1.6e-05 25.1 0.0 160 197 727 764 720 768 0.91
10 33 4.7e-09 1.5e-05 25.2 0.0 159 197 771 809 764 813 0.90
11 33 4.7e-09 1.5e-05 25.2 0.0 159 197 816 854 809 858 0.90
12 33 5.1e-09 1.6e-05 25.1 0.0 160 197 862 899 855 904 0.91
13 33 4.7e-09 1.5e-05 25.2 0.0 159 197 906 944 899 948 0.90
14 33 4.7e-09 1.5e-05 25.2 0.0 159 197 951 989 943 992 0.90
15 33 4.9e-09 1.5e-05 25.2 0.0 159 197 996 1034 989 1037 0.90
16 33 4.7e-09 1.5e-05 25.2 0.0 159 197 1041 1079 1034 1083 0.90
17 33 4.7e-09 1.5e-05 25.2 0.0 159 197 1086 1124 1079 1129 0.90
18 33 4.9e-09 1.5e-05 25.2 0.0 159 197 1131 1169 1124 1172 0.90
19 33 4.6e-09 1.5e-05 25.2 0.0 159 197 1176 1214 1169 1219 0.90
20 33 4.6e-09 1.5e-05 25.2 0.0 159 197 1221 1259 1214 1264 0.90
21 33 5.2e-09 1.6e-05 25.1 0.1 160 197 1267 1304 1260 1308 0.91
22 33 4.9e-09 1.5e-05 25.2 0.0 159 197 1311 1349 1304 1352 0.90
23 33 4.7e-09 1.5e-05 25.2 0.0 159 197 1356 1394 1349 1398 0.90
24 33 4.6e-09 1.5e-05 25.2 0.0 159 197 1401 1439 1394 1444 0.90
25 33 4.5e-09 1.4e-05 25.3 0.0 159 197 1446 1484 1438 1489 0.90
26 33 4.7e-09 1.5e-05 25.2 0.0 159 197 1491 1529 1484 1533 0.90
27 33 4.9e-09 1.5e-05 25.2 0.0 159 197 1536 1574 1529 1577 0.90
28 33 4.7e-09 1.5e-05 25.2 0.0 159 197 1581 1619 1574 1623 0.90
29 33 4.7e-09 1.5e-05 25.2 0.0 159 197 1626 1664 1619 1668 0.90
30 33 4.9e-09 1.5e-05 25.2 0.0 159 197 1671 1709 1664 1712 0.90
31 33 4.6e-09 1.5e-05 25.2 0.0 159 197 1716 1754 1709 1759 0.90
32 33 4.6e-09 1.5e-05 25.2 0.0 159 197 1761 1799 1753 1803 0.90
33 33 4.3e-09 1.3e-05 25.3 0.0 159 198 1806 1845 1799 1849 0.89

Sequence Information

Coding Sequence
ATGCCGGTGCTGGGCTACGGAGAGATGGCCTCACAGGACATGTGTCCCATGGGATACAGCTCGGACTACATGCTGCCGACCTGGGACAAGCACGTTGAAGGATACTCGGCGTACGCGCACCGCGTCCCCGTCGCCGGCGCCGTCGCCGCGACATACAACACAGAAGACAGTGACATGCAACTGGAGACGAGCAGCAGCGAGGCGAGCGCGACCAGCTCCACGACGCTGTCGCAGCACTGCGCCATCTGCGGCGACCGCGCCACCGGCAAGCACTACGGAGCCTCCTCCTGTGACGGCTGCAAGGGATTCTTCAGAAGAAGTGTCAGGAAGAACCATTTGTATACGTGCAGATTTAGCAGAAACTGCGTGGTGGACAAAGACAAAAGGAATCAGTGCCGATATTGTAGGTTAAGGAAATGTTTCAAAGCGGGAATGAAAAAAGAAGCGGTGCAGAACGAACGCGACCGCATCAACTGCCGGCGGCCGTCGTACGAGGAGCCCACGCAGGCCAACGGACTGTCCGTCGTGTCGCTGTTGAACGCCGAGCTGCTCAGCAGAAAGGTAATCGATGAGACAATAAACGTAAGCGACGCGGAAATCAACAACAGGAAGTTGGCGAAGATAAACGACGTGTGCGACTCCATCAAGCAGCAGCTGCTGATACTGGTGGAGTGGGCCAAGTATATCCCCGCCTTCACCGAGCTGCATCTGGATGATCAGGTGGCGCTGCTGCGCGCGCACGCGGGCGAGCACCTGCTGCTGGGCTGCGCGCGCCGCTCGCTGCACCTCAAGGACATCCTGCTGCTCGGCAACAACTGCATCATCACCAAGCACAACATCGACGGGCGCATGGACATCGACATCAGCATGATCGGCATGCGCGTGATGGACGAGATCGTCAAGCCGCTGCGAGAGATCGACATCGACGACACTGAGTTCGCGTGTCTCAAGGCCATCGTGTTCTTTGATCCTAACGCGAAAGGCCTCTCACAGCCGCAGAAGATCAAGCAGCTGCGCTACCAGATCCAGATCAACCTGGAGGACTACATCAGCGACCGACAGTACGACGGCCGCGGACGCTTCGGAGAACTGTTGCTGTGCCTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGGGCATCCACAGAAGCCGGTATAGAGGAGAACAGTACGGAGTGCGTGCCGAATGcaggcgcgggcgcgggcgcgggcgagtGTCGCGCGGGGTCGCCGCCGCTCGTGCCCACGCTGCCGCTCGCCTTCACGCCCATGCCCTTCAAGCAGGAGCCCAACATGAGCCCAGGGCCCGACTCACAAGTGGCGAAGACTGCtgacattacattattatag
Protein Sequence
MPVLGYGEMASQDMCPMGYSSDYMLPTWDKHVEGYSAYAHRVPVAGAVAATYNTEDSDMQLETSSSEASATSSTTLSQHCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHLYTCRFSRNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRINCRRPSYEEPTQANGLSVVSLLNAELLSRKVIDETINVSDAEINNRKLAKINDVCDSIKQQLLILVEWAKYIPAFTELHLDDQVALLRAHAGEHLLLGCARRSLHLKDILLLGNNCIITKHNIDGRMDIDISMIGMRVMDEIVKPLREIDIDDTEFACLKAIVFFDPNAKGLSQPQKIKQLRYQIQINLEDYISDRQYDGRGRFGELLLCLPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGASTEAGIEENSTECVPNAGAGAGAGECRAGSPPLVPTLPLAFTPMPFKQEPNMSPGPDSQVAKTADITLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01430034;
90% Identity
iTF_01430034;
80% Identity
iTF_01430034;