Basic Information

Gene Symbol
Zfhx4
Assembly
GCA_026168455.1
Location
CM047426.1:93283686-93292902[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.019 7 9.3 0.4 3 23 69 90 67 90 0.95
2 14 0.011 4.1 10.0 0.6 3 23 111 132 110 132 0.95
3 14 0.0088 3.3 10.3 2.4 2 23 195 217 195 217 0.95
4 14 0.0082 3.1 10.4 1.9 1 23 234 256 234 256 0.97
5 14 0.28 1e+02 5.6 4.0 2 23 263 285 262 285 0.96
6 14 0.32 1.2e+02 5.4 5.9 1 23 374 398 374 398 0.91
7 14 0.0046 1.7 11.2 0.6 1 22 418 439 418 442 0.89
8 14 0.0064 2.4 10.7 0.3 1 23 483 507 483 507 0.92
9 14 0.084 31 7.2 0.1 3 21 556 574 554 575 0.93
10 14 0.14 51 6.6 2.0 2 19 720 737 719 742 0.91
11 14 9.7e-05 0.036 16.5 2.5 1 23 1308 1330 1308 1330 0.99
12 14 0.0019 0.69 12.4 0.3 1 23 1414 1436 1414 1436 0.98
13 14 0.0041 1.5 11.3 0.3 2 23 1579 1601 1578 1601 0.96
14 14 0.44 1.6e+02 5.0 0.4 2 21 1875 1894 1875 1898 0.89

Sequence Information

Coding Sequence
ATGGGTGTAGAAAGTGAGGTTAGAGAGAAATACAATAGTAAAAAAAATGAAGTTAGAGGTGAAAGTGACAGCAAAAGATTAAGCAAGGACAAAAGCGAACGACGAGAAGATGAAAGCGAATTTGGGAGCGAAATAAAGCAAGAAATAGAACAAGAACAAGAGCAAGAGCAGGAACAAGAAGCGGAGACTGAAGATATCATAAACTGTTCATTTTGTTCATTTCAAACGACATCGAACGAGGAGTTACGAAATCACATACAGATCGCTCATACTCAAGATAACGATGAACCAATGGAAACAATGAAAGAAAGGTCAGGATCAGACTTACTTTGTCCTTTGTGCCAAGACTGCTTTAAACAACGTGCCGCGTTAGAGAAACATGTAATGCAAATACATTCGGTAAATTCGGATGGTTTACAAAGGTTGCTACTCCTCGTCGATCAAAGCCATTGGTTGAACAATAATCCACGTAGTATAAACGCATCGATCCCTTGCCCGAGATCACCGAATATTTTATTTAAAAAAGGTCAAGAGGAAGAGAACATTGAGCAAATCGGTAGCGATGACGGTGAAGAGACGGCCAAGTGCAGCGTATGCCCAAGAGTGTGCCGAACAATCGAAGAGCTCCAGCAACATCACAAAGAAGCCCATTCGACGTCGATTCCAACTTTGGCTGTCAGCGAGAAGCATGTATATAAATACAGGTGTGGACAGTGCAGCTTAGCTTTCAAGACGTTCGAGAAACTTCAGCAACACTCGCAGTACCACGCGATAAGGGACGCGACCAAGTGCGCCATATGCTGCCGTTCGTTTCGATCGGTCCAAGCTCTTCATCGTCATTTGGAAACAACTCACACGGAATTGCAAGAGGACGAGCTGGCCCAATACAAACAGAGCTTAATCAATTCTCACCCGCTTTTTCAAGCTTTAACCGAGGAGGCGCTAAGAAGGCAAGGGATTTTCGGTAACGAGCAAATGATGGAAGAGGAGAGTAAAATCGAAGACGACGAGAGCGACATCAATGATTTGTCACCGCTGCACAAGGAGCAACGTTTGCTCGAGGATTATTTGAATAGTCAATCGATAGCCGAGGATTCCTATAACGATCCCGGGAGGAAATTTAAATGCCATCGTTGTAAGGTTGCTTTTACGAAACAGTGTTACTTGACCGGTCACAACAAAACGTTGCTTCACCGTAAAGGTGAGAAAATGCCATATCCTATGGAGAAGTATTTAGATCCAAACAGGCCATACAAGTGTGACGTATGTAAAGAAAGTTTTACGCAAAAAAATATACTTCTCGTCCATTACAATAGTGTAAGCCATTTGCATAAACTGAAAAGGGCTATGCAGGAGCAAGGGAATAATAATACACTTATTACAGTAGCACCTCCCATGAGTCCGACGGAAGTAAGCGATAGTCAACAAGATCAGGATAAGAAACCTTATAAGTGCAATATATGTAAAGTTGCTTACTCTCAAGGAAGTACATTAGATATCCATAAGAGAAGCGTACTTCATCAAACTAGAGCTAGTAAAATTCACGATCTAGCTATAAGCGGTCAGTTAGATCTCGCACGGCCCTTGATCGAGCAACCAGTATTAAGCCCGAATAATTCCTCGTGCAACAACAACATGGAGAGCTCCAACTCTCACATGCTCGCGTGTTCACGGTGCAACGCGTTATTCGCCAATCAAGAGCAACTTTCCAACCATCAGCAATTGTATTGTATTTTCAGTAATCCTCTAGCATTGTTCCAACAGCTCGCCTCCTCTCAACAATTGGCCATGTCCCCGACGAAAACGCCACCACCATCCGTCTCGTCTACTGGATCCCAGGAGAAGCACGCTCTACCATCGAATGCACAAGCTCTGATACCTTCTCAAGACCCCCTTTATCAACCGAAACACAAGACATCCCAAATGTACAAACATTTGCTCGAGAGTTTTGGATTTGACCTAGTAATGCAATTCAACGAGAATCATCAACGAAGACAGAGAAAGGAAGAAGAAGCAGCTGCCGCTTATCAATTACACCAGGAGCAGCAGAACGAAGAGCAACAGAAGCAAAGCTTCGAAGGTCAAATATTGCAAGAGAAGGAGCAAGATATCGAAGATCCACCGGAAGAAGAAATCATTCCGGAAATTAAGAGGAGTACTTGCCAACATTGCAACAAAGAATTCAGTAGCGTATGGGTTCTTAAAGCACATTGCGAAGAGGTACACCGCGACTTAGTTCCTCGAGAGTTCCTAGAAAAGTATGCGCAACAATTTAAATGCGAATACGAAAAGAAAATAGTAATCGTGACAGCTGCCACATCCTCTTCGGCAAACACAGCTCCAGTGACAACGACACCTACGTCCTTTCAATCACAAGACAATAGCGTAAGCGAGAATAAGGAAAAAGACGATTTATCCGAGACTAAAGAACGCAAGAGCAAAACTCCAGAAGCCACTTCCACAACTCCAACGACAACTCCAGCGTTAAGCAATACACCGGTATCCAGTACAGATTCCGCAACACCCACGGCACAAACTAACATTTCGCAAAATCTCATTCAACACCAGCAGCAGCAGGTTCAAATGTCGTTAGCGCAACACATGTCCGAAATGCAAGCCGCGTTTAACGCAATGGCGGCATCTCAATTGCAGCAACAACTTCATCAGTATCCAAGCTTAATGATGAGTATGATGGGTCTTCCGCTAGGACTCAACGTACCTGCTCTTGCAGCTATGAATTTGCAGCCCCCATTAGTACCAGTTATGTTACCACCACCAGCTTTCGATGGGAATAACACCACTTATACATCCATGACACCGCAATCCGATATACTAGCAAAACAGCATATTGCATTACAACAGCAGCAGCACGTAGTTGCAGCAAACGTCGCCGCATCACAAAAGCGAGCAAGAACGAGAATAACCGACGACCAGCTAAAAATCCTAAGAGCTCATTTTGACATAAACAATTCGCCTGGAGAAGATCAAATAATAGACATGGCAGCCCAAAGTGGTCTACCCCCAAAAGTGATAAAACATTGGTTTCGGAACACATTATTCAAAGAACGCCAGCGAAACAAAGACAGCCCATACAACTTTAATAATCCTCCTAGTACGACGCTAAACCTCGAAGAATACGAGAAGACCGGTGAAGCTAAGGTAATGCCGCTCAGTTCAACTGCGATCGTCAACACAATGGAAGATAAAAGTGAAGAGAAGCGGGAATTGGCAGCTGCTACAACCCCGACAAATTTGAGTATGATAACGCACAATGAAACTATAAAACACGAATTTCTGGAGCAAAGCGCATTGATGCAGCACTCGCACGACGAGCACAACTCGCCTGAAAGTTCGGGCGATCAACAATCGAGACCACAATCTCCCGCGATAACTTCCGTATTTACGAGTGGTCATCAAGATATTTCAACGACAATGTCCGCTACAATGATCACTCAGACGTCACCGATGCTTCCTCCTAAAGCGACCCCACAAAATTTTATGTGTACAAGTCCGCAAATGACGAGCACTTTATCAGCGAACACCTCACCGATCTCTTTAACAAGTCAACGGTGCAACAGTCCAACCAGAGTCACCGACTTTTCGTTCAACGGTAACAATAATGGAAGCAATAGCGGCAACAGCAATTCTGGAAAACGAGCCAATCGAACAAGGTTTACCGATTATCAAATAAAGGTACTTCAAGAATTTTTTGAAAATAATGCTTATCCTAAAGACGATGATTTGGAATATCTAAGTAAACTATTGGGTTTGAGCCCCCGAGTGATTGTTGTGTGGTTTCAAAATGCTCGACAGAAAGCACGCAAAGTATACGAGAATCAGCCTCCACTCGAACCTCTTACACCAGGCGGACGCGAGAGCGACGACGGAACGGGGAGATTTCAAAGAACGCCCGGGTTGAATTATCAGTGCAAAAAATGCCTCCTGGTATTCCAACGGTACTACGAGTTGATACGACATCAAAAGACACATTGCTTCAAAGAGGAGGATGCCAAACGCAGTGCTCAGGCCCAAGCTGCCGCGGCTCAAATCGCCGCGGCTCTTAGTTCCGAGGACAGCAACAGCAGCTCCACCACTACCAATACTCTTCAGTCATCTTCCATGAACGTTCAGTCCGAGCAGTCCTCGAATTCGAACGCAGCGTTCCTACAACACCAGCAGACGGCTCAGCAGGTCCAGACGAATCAACCCAACATTCAATCCGAATCGAAAGACGAAAATTTTCAATGTGATAAGTGCAACCTCGTGTTTGGTAGATTCGAGTTGTGGCGCGAACATCAATTGGTACATATCATGAACCCAAATCTATTTCCACCGAGTTACCCGCCCGACTCGGCGTTCGGTATTTTGCAGCAACAAGCACTGAACAACGCGAGCAACGCACCCGACGTAGCAACGCACCCGTTGCTCAACATATTCCAAGACCAAAAACGCAAATACGACGAATACGAGGACGGTCACAACACGGATAACAAATCAAATTCCGATCATAACGAACAACCGAAAGACAAACGTTTACGCACAACGATCCTTCCGGAGCAGCTCGATTATTTGTATCAGAAGTATCAGGTCGAGTCGAATCCATCGCGAAAAATGTTAGAAACTATAGCTCGCGAAGTTGGGTTGAAAAAGCGCGTCGTGCAAGTGTGGTTTCAAAATACTCGCGCTCGCGAGAGAAAGGGCCAGTTCCGAGCGCACAGCCAAGTAATAAACAAACGGTGCCCATTTTGCCCAGCTCTCTTCAAAGTTAAATCAGCTCTCGAATCTCATTTGAATAGCAAGCACACTGATCAAATTGCTCGAGGCGAGGTGAACATAGACAACATACCCGACGAGGAACTCTCGTTGGAATCGTCTCCGTCGAATCCGAGCACACCCAACATGATGCCACCGCTGTTCCCCCCGATCAGCACCGAAGTCGAGGCTTCCCTCAAAAAGTATTACGAAGAATCAATGAAACGTTACCTCACCGAATTGCAGGCCCACGCGAGTAACGGAAAGCAAGATGCAACCAGCTCTCTATTTGGTGGCAACAGCAGCGAGTCACCCCTCGATTTGAGTAAACCGGTCGACTTGACCAAATCTGTCAAATTAACGATCAATAATTTAGGCAATCTACTCGAAGAACAGAACAATTCTCAGCAGATTCGCAGCGGCAGTGATTGCGGACCACTTACCGATTTGTCGGAAAAGAGTATCTGCGATGACGACAGCATGAGCGAAACAACCGAATTCCTCGATGACGAGAGTAGTCCTACTAGCCCGGCTTCGAGTTCACAAAGCTCCAAACAGGGATTGAGCGGCACTAATATTGGTAATAACCTAGGCGTCTGTACTGGAGGCAATACATCCGTGCAAACTGGAGGAAAAAGATATCGCACTCAAATGTCGACCACGCAGGTGAAAGTCATGAAATCTTTATTTTCGGATTACAAAACTCCAACAATGGCTGAATGTGAAATGCTCGGACGAGAAATAGGACTTCCTAAACGAGTTGTTCAGGTATGGTTTCAGAATGCACGTGCTAAAGAAAAGAAAGCTAGATTAGCTGCGGGTCTATCAGCGGATGGTGCAGTAATTCATCGTGGCTTAACTGGTCCTGAAGAATGTAAATTATGTTCCATACGCTACTCTCCTAAATCGCCTTTGCAAGAACATGTATTTTCGCGGAGACATATTGAATCGGTAAGAACTGCCGTTGAGGACGGCAGTTTGGTACCACCAACTCCTGGAGCTCCTATAATACGGGAAAGTGCCATTGCAAGTTCTACAAATAATAATCTGCAaggcaaccaaccgcagactgaagaaaatatgatgtacgggtcgttgttccttcatcccacggcaatgtttcagtcgcagcagcagcagcagccgcagcaacaacagcagcagcagccgcagcagcagcagcagcagcagcagcaatcgcagcttcagccgcagcagcaacatcatcagccgcagcagcagccgcagcagcagcaacagcaacataccgggaatgtcacaaccagcacgactaccaccacagccggtgagtgtctggctgacctcttagattcctAA
Protein Sequence
MGVESEVREKYNSKKNEVRGESDSKRLSKDKSERREDESEFGSEIKQEIEQEQEQEQEQEAETEDIINCSFCSFQTTSNEELRNHIQIAHTQDNDEPMETMKERSGSDLLCPLCQDCFKQRAALEKHVMQIHSVNSDGLQRLLLLVDQSHWLNNNPRSINASIPCPRSPNILFKKGQEEENIEQIGSDDGEETAKCSVCPRVCRTIEELQQHHKEAHSTSIPTLAVSEKHVYKYRCGQCSLAFKTFEKLQQHSQYHAIRDATKCAICCRSFRSVQALHRHLETTHTELQEDELAQYKQSLINSHPLFQALTEEALRRQGIFGNEQMMEEESKIEDDESDINDLSPLHKEQRLLEDYLNSQSIAEDSYNDPGRKFKCHRCKVAFTKQCYLTGHNKTLLHRKGEKMPYPMEKYLDPNRPYKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMQEQGNNNTLITVAPPMSPTEVSDSQQDQDKKPYKCNICKVAYSQGSTLDIHKRSVLHQTRASKIHDLAISGQLDLARPLIEQPVLSPNNSSCNNNMESSNSHMLACSRCNALFANQEQLSNHQQLYCIFSNPLALFQQLASSQQLAMSPTKTPPPSVSSTGSQEKHALPSNAQALIPSQDPLYQPKHKTSQMYKHLLESFGFDLVMQFNENHQRRQRKEEEAAAAYQLHQEQQNEEQQKQSFEGQILQEKEQDIEDPPEEEIIPEIKRSTCQHCNKEFSSVWVLKAHCEEVHRDLVPREFLEKYAQQFKCEYEKKIVIVTAATSSSANTAPVTTTPTSFQSQDNSVSENKEKDDLSETKERKSKTPEATSTTPTTTPALSNTPVSSTDSATPTAQTNISQNLIQHQQQQVQMSLAQHMSEMQAAFNAMAASQLQQQLHQYPSLMMSMMGLPLGLNVPALAAMNLQPPLVPVMLPPPAFDGNNTTYTSMTPQSDILAKQHIALQQQQHVVAANVAASQKRARTRITDDQLKILRAHFDINNSPGEDQIIDMAAQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGEAKVMPLSSTAIVNTMEDKSEEKRELAAATTPTNLSMITHNETIKHEFLEQSALMQHSHDEHNSPESSGDQQSRPQSPAITSVFTSGHQDISTTMSATMITQTSPMLPPKATPQNFMCTSPQMTSTLSANTSPISLTSQRCNSPTRVTDFSFNGNNNGSNSGNSNSGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLGLSPRVIVVWFQNARQKARKVYENQPPLEPLTPGGRESDDGTGRFQRTPGLNYQCKKCLLVFQRYYELIRHQKTHCFKEEDAKRSAQAQAAAAQIAAALSSEDSNSSSTTTNTLQSSSMNVQSEQSSNSNAAFLQHQQTAQQVQTNQPNIQSESKDENFQCDKCNLVFGRFELWREHQLVHIMNPNLFPPSYPPDSAFGILQQQALNNASNAPDVATHPLLNIFQDQKRKYDEYEDGHNTDNKSNSDHNEQPKDKRLRTTILPEQLDYLYQKYQVESNPSRKMLETIAREVGLKKRVVQVWFQNTRARERKGQFRAHSQVINKRCPFCPALFKVKSALESHLNSKHTDQIARGEVNIDNIPDEELSLESSPSNPSTPNMMPPLFPPISTEVEASLKKYYEESMKRYLTELQAHASNGKQDATSSLFGGNSSESPLDLSKPVDLTKSVKLTINNLGNLLEEQNNSQQIRSGSDCGPLTDLSEKSICDDDSMSETTEFLDDESSPTSPASSSQSSKQGLSGTNIGNNLGVCTGGNTSVQTGGKRYRTQMSTTQVKVMKSLFSDYKTPTMAECEMLGREIGLPKRVVQVWFQNARAKEKKARLAAGLSADGAVIHRGLTGPEECKLCSIRYSPKSPLQEHVFSRRHIESVRTAVEDGSLVPPTPGAPIIRESAIASSTNNNLQGNQPQTEENMMYGSLFLHPTAMFQSQQQQQPQQQQQQQPQQQQQQQQQSQLQPQQQHHQPQQQPQQQQQQHTGNVTTSTTTTTAGECLADLLDS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01428099;
90% Identity
iTF_01428099;
80% Identity
iTF_01428099;