Basic Information

Gene Symbol
RREB1
Assembly
GCA_937641085.1
Location
CALMRH010000092.1:1066342-1072552[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0068 1 10.7 0.7 1 21 263 283 263 285 0.95
2 13 0.00028 0.042 15.1 0.2 1 23 295 317 295 317 0.98
3 13 2e-05 0.0029 18.7 7.5 1 23 323 345 323 345 0.98
4 13 0.44 65 5.0 3.6 2 19 554 571 554 571 0.97
5 13 0.1 15 7.1 1.1 1 20 608 627 608 629 0.89
6 13 0.0075 1.1 10.6 0.1 1 23 807 829 807 829 0.97
7 13 3.6e-05 0.0053 17.9 1.1 1 23 839 861 839 861 0.99
8 13 0.0007 0.1 13.9 2.0 1 23 867 890 867 890 0.97
9 13 0.0026 0.39 12.1 2.1 1 23 1257 1280 1257 1280 0.95
10 13 7.3e-05 0.011 16.9 0.3 2 23 1608 1629 1607 1629 0.97
11 13 0.12 18 6.8 6.3 1 23 1635 1658 1635 1658 0.97
12 13 0.0071 1.1 10.7 0.5 3 23 1843 1863 1841 1863 0.96
13 13 0.0012 0.17 13.1 4.8 1 23 1869 1891 1869 1891 0.99

Sequence Information

Coding Sequence
ATGAATCCAATGCTAGGTGCAATCGGATGTGTTCGCTCCTTGCTTTGCTCCTCAATTTCGGCCAGCAGAAGCTTTAAAATGATCAAGACAGCGACCTCCTGTAGCAGCCAACAACAGGGCGACTGCAGCCACGTGGGGCAGCCGGTGAAGCTGGAGCGGCGCGGCTCCGAGACGTCCGAGTCGTCCTTGGAGCACCTCGATCTCGGCCGGACTCCGAAGAAGCTCAGCGCGCTGTCTTCGGCCACATCGACGCCGCACACGACCTCCAACAGCAACGCCGACAACAGCCACGCAGTCGCCAGCGCCGAGCACGTCAACCGAAGCAGCAACGAAGCCGCGAAATCGCAGCGCGACTCCGACGAAGCGAACGACTGCGATGATGACGAGTCGGCCGACGAGAAGCAGCTCGGCAGCGCGGGCCGCAGCTCGCATCGGCATTTCCATCACAAGCGCCGCAGCAGCGGCCGCATGGACAAGCAGACGGTGCAGCTGGAGATCAACGCAGAGAACCCGAACTCGCTGCGCAAGAAGTTCCGCTTCAGTCGCAGTGCGGCCGACTCGCACTCGCTCGCCACCAACAACGAGTCGGGCTTCGTCGACGCCAGCACGAGCAGCAGCCAGCTGCTGAACGCCTCCGCCGCGCCGCCAGCGCAGCAGCATTCGCCCGAAGCGTGCGCTATCGGCTCGCAGAGTTCGTCGTCGGCGTCGTCGTCGCCGCACGGAGCCGGCGCATCGGCCTCGGCGTCGAGTCCCGAGTCGGGCATCGGCGAGCGCGACGACATGAAGTTCGTGTGCCCGATTTGCGAAGTGGTCTCGGCGACGCCGCACGAGTTCACCAACCACATCCGCTGCCACAACTACTCGTCCGGCGACACGGAGAACTTCACCTGCCGCATCTGCTCGAAGGTTCTGTCCTCGGCTTCGTCGCTCGATCGCCACGTTCTCGTGCACACGGGCGAGCGGCCCTTCAACTGCAAATACTGTCACCTCACCTTCACcacgaacggcaacatgcatcgccacatgcgcacccacaagcagcatcagcacaaccaccaccaccgccgcaactcgaatggaaccgcgcctgcgctcaagcacgccaacaacaacaacaacaacgctgcgacgatcacagtgcaaacaaccgctgctgctgctgctatcaacgcttcattaacgaacggcagcaacgtcgaaggagtgaagtcagcaaaacccatcaacggcgcaagctcaaacgggcggctgctgaatggcggcgattgttacgacagcgacggcggctgttcgacggactcatcaagtgccatcagtcacaattcacataatcccaacaacaacaacaacaacaccatgaacaacatcaattacaataacaacgtcaacaactgcaaacgcaagcacaacgacgcgttggatgccgatttcagtttgctgaagcgccgCGTGAAGACAACGATTAACAACAACATCATTAGCGATGAGAAAGGCGCATCCGTTGCAGAGGATGAGCAGCAGAGGGCGCTAGCAGCCGCTCATCGCCGCCAGCATCAGGCAGCGCAGCACTTTGCCTGCCCCGTTTGCATTGGCAGCGACTTCGAATCGATGCTGATGCTCAGCGCACACATGGACAGCGAACACTGCGACATTCCGGCCAAATGCCGCCACTGCGACGTGGTTTTCCATACACATCGCCAGCTCAACGTGCACCCCTGCACCAACCGACAGCCGAGGACGCCGCCGCGCCCCAAGGATCTCACCTACGCCGACTTCAGCAGCGAGAAGCCTCCATCGGTGGTTGATCCCTCGCGTCAGCTGTTCGACTGCCCGAAATGCGGCTGCACTTTCCGCTGCGCCAACGACTTGGAGATGCATGTTGCCGAATGTCGCGCGCACTCGTTGCATCGCATCTTTCACTCCGCGGAGTACGACTTCGACCGCGAGCGATTTCAGCAGCGAACTTTCAAGACGCGCGTCGCCAGTGAGAGCTCCACCGGCCTCGACGATGGCGAAGCCGAAGAAGAGGACGACGATGAGGAAGAGGATCAGCATCAGCAGAAGCAGCAGCAAGATAACAGCGAGGAGTTCTTCAAACGTTTGTATTTGAAGCACAAAGCCGATATCCATCGCCAAAACGCTTGTCTGTCGCCGCAGCCCTCCGTCGACGATCGCCTCGACGACATGAAGTTCGAGGAAGATTGCGAAAAGCTGCAACAACAGTCGCACGACTCCAAAGACTTGGCCGACATCCAATCGATCCTCAACATGACCTCGTCCTCGTCCACCTCGAACTTCCTCAAGAACTTCGAACACTCTGTCAACACGCCGTCCAGCAACTACGGCATGGACAAGGATGAGGAGGAGGCTCAGGACGCCTTCACGTCCGAGTTCCGCAAGATGAAGTTGCGCGGCGAGTTCCCATGCAAACTGTGCACCGCGGTGTTTCCCAACCTGCGCGCCCTCAAAGGCCACAACCGCATCCACCTGAGTGCAGCCGGGCCTTCAAGTCCGTTCCGgtgcaacatgtgcccgtattcgatctgcgacaaggctgctctggtccgccacatgcgctcgcacaacggcgaccgtccctacgaatgcgccgtctgcaactacgccttcaccacgaaggccaattgcgagcggcatctgcgtaatagacacgCCAAGACCACACGCGACGAAGTCAAACGTGCCATCATCTACCATCCTTCTGAGGATTCCTCCTGCGAAGACCCGAGCAAGAAGCTGCATCTCTTCTCCTCGCCCGAAATCGATGACGACGTCGACTTGCAGTACCATCAGCACCATCAGCCGAAGGACCGATCGACGCCAGTGTCGCACCTGAAGGAAATCCTGACGTGTGAGGACGGCCGCTCGAGCAAAGCAATGAAGATCCAAGTCAAGAGCATTGACAAGTTGCTGGACAAGTCAACCGCCTCCTCCAGTTACAATGAAGTCTTTCGGGAGGACGAGGAAGAGGCGGAGGAGGAAAGGCCTTTGAATGCCAGTCACCATGCGACAGATCAGACCAATCACTCTCCAATTGATCTGAGCATGGACGTCCTCGATTTGAGCAAGAAGCCGGCCAAGGTTTCGGTACCGAAAGAACAGCCACCGTGCACATTACCAGCTCCCACACCAGCTGCACCCGAAGGCGTTACCACGTCCGCACCTCCGACGGAGGACCCAAAATTCGACATCAGCGTCCTCGAAAAGAATCAGCAGTATTTATTGGCTCAACAGCAGCTGATCAACGAAGCGTTGCCGAAAATTGTGGATCCGTCGCACTACTTCCAGCAGCTGTATCGCAACTTGGTATTTCCGCCTATGAACCCGATCAATCCGTTCTTCTTGCACAACTCCTTTCTGCCCAGCAACATGACCGATCTGCAGAAGTACGCTCCGTTGATGAGTCGTATGTTCGCGGGCTCCGCGCCCACCTCTCAAATGGCAGCTGCTGACAGCATGAAGACTCATCCGCCAAACCCGAACTCGCTGTCAACATCAACTCTGATGCCGCAGGCGAGTCCTCTGTTGTCCGATAAATCGAGCGCTTCATCGATAACCTCTTCGCCGATGAGCACGAACAGCATGCACCCGAAACCAGTTGCCACGCCGACATCTTCGCAGTCCCTCAACATTCCGCGACACCCGGGCATGCAGTCCACAACTCTGGCCGGTGGACCCGTCAAGATGGTCATCAAAAATGGAGTGCTCATGCCGAAGCAGAAGCAAAGGCGCTACAGGACCGAGCGCCCCTTCGCCTGTGATCACTGCTCCGCGAGATTCACGCTGCGTTCGAACATGGAGCGCCATGTCAAGCAGCAACATCCTCAGTTCTACGCGCAACGGCAACGGAGCGGCCATCACATCATGCGCGGGCGTGGTGCCAGCAGCGCAGCAGCCATGAACAACATTACGCACTTGCAGGCAGCTATCGCCGCACATAACGGCAACGGGGTGCATGTGGGCCCAGCTTCTATATCCGAACAAGTGAAATACGCGATTTTGGCCCAGCAGCTGAAGGCGCGGAAGGACACAGACCTCCTGCAGCAAGCTTTGGCACACGGCTCCAGTAGCGTAGCTCCCGGCCACCTAAACTTAAGCCCCGCTGGCGGCTTACTTCCATCACAGAAGGATCTCAATCACCTTGGTCTAGACCACTTGAATAACTCCACTGTCAACGGTTCGCTGGAGGAAGAAGATGATCCCAAGCTGGTTATTGATGAAGACGACGACTGTGACGAGTCGTTTATGGAGGACCACGACGACGGACAGTACCAGGAGCAGGGGGAAGGTGAGGTGGTAAATGGAAGCGTCAATGGGCACGATTTGGTCGGCGATAAACAAAAGATGCAAAGTCCAATCGAACCAGCAAATAAATCGGCGAAAAAAGTCGCCGAGACGATCCTTGAACAGGCCATCAAAGCTGGTGGCAGCTCCAGCTACAACTCAAACATAAATTCCAGCTTGAATGCGTCCCCTCAGCCAGCCAAAACGATGAAATCCATGATTGCTCAAGCCGAATCCGTCGGGAAGTTCCTCAAAGAAGTTGCTAGCTCGCCTTTTAAGGACGAGTCGCAGGATTTGGTGCCGGTGGCGAAGCTGGTGGACAACGCCACCACCAACGCAATGTCCTTCAACAACTACTTCCGTCCTAGCGACGTGGCCAACCACATGGAGCAAAGCGACGAGGAAGGACTGGTCGCGTCTGGCAGCGCCTCGGAGAGCAACAACTCGGGCACGGAGGACATCGCATCCTCAGCCGAGCCGAAGAAAAAATCGGCATACAGCTTGGCGCCGAATCGGGTTTCTtgcccgtactgccagcggatgttcccctggtccagctccctgcggcgccacattctgacgcatacgggccagaagccattcaagtgctcgcactgcccgctgctcttcaccacgaagagcaactgcgaccgacatttgctgcgtaagcacggCAACGTCGAGTCGGCCGTTTCGGTGTACGTGCCGGCCGAAGACGTCAACGAACCGATTCCAGTTCCGAAATCCGTGGAGGAGATCGAGCAGCAGCAACGTCAGCGCGAAGAGGAACGAAAACGCAAGTCCGAAGCTGAAGCCGCTCGAATCGAGAAGGAACGCAGGGAAAAGGAACAACGTGAGCAAGAGGAACAGGAGCGAAAGGAAACTCTTAAGGAACTCGCTGCTGCTCAATTCAACCAGTCCACAGGGCAGACTTCGAATGTAAAAGCGCAGGATTCAGCAGCTGCCTCTGCTGCAGCTTATTCGGAGTTGCCTTTCAAGTGTCACCTCTGTGACTGCTCCTTTGGCGAGCGCTTTCAGTGCCTGGACCACATTAAAGCCCAACACGCCCAAGAGTTTTCCCTGCTCCTGGCCAAGGGCGCCATCGACACCGATCCAGACCATAACCAAGTCCATTCCACGGAGGATGAGGAGTGCCGACGACCGGGCGAAGACAGCAACGGCCGCTGCGGAAAGTATCCCGACTACAGCAACCGCAAAGTGATCTGCGCCTTCTGCGTGCGTCGCTTCTGGTCCACTGAggatctacggcggcacatgcgcacccattccggagaacgtcctttccaatgcgacatttgcttgcgcaagttcacccTCAAGCACAGCATGTTGCGCCACATGAAGAAGCACAACGGACGGCATCACAGTGCTGGGGCCGGCGACCTCTCCAACGCCACGAACAGCGGCTCCGATCTGTCGGACGACGAGCAAATGTCACCCACAACACCAACGAACGCCATTGTGATGGCCAACACGCTGGCCATGCGCACGCACAAGATCCAGGAGCTGCTGAACAAAGCCAATGAATGGCGCACAAATCGCATGTCCTTGGGCGAGCACAAGGAGAACATCGGCGAAGAGCACAACACGCAAACGGATCTAATTGGCAATCTCCTCGGCATCAGCGACCAAGGAATTTTGAACAAGCTGCTGTCATCCGCAGACGAGGCTGCCAAACTTTTAGGCGTAGAGAAGTAG
Protein Sequence
MNPMLGAIGCVRSLLCSSISASRSFKMIKTATSCSSQQQGDCSHVGQPVKLERRGSETSESSLEHLDLGRTPKKLSALSSATSTPHTTSNSNADNSHAVASAEHVNRSSNEAAKSQRDSDEANDCDDDESADEKQLGSAGRSSHRHFHHKRRSSGRMDKQTVQLEINAENPNSLRKKFRFSRSAADSHSLATNNESGFVDASTSSSQLLNASAAPPAQQHSPEACAIGSQSSSSASSSPHGAGASASASSPESGIGERDDMKFVCPICEVVSATPHEFTNHIRCHNYSSGDTENFTCRICSKVLSSASSLDRHVLVHTGERPFNCKYCHLTFTTNGNMHRHMRTHKQHQHNHHHRRNSNGTAPALKHANNNNNNAATITVQTTAAAAAINASLTNGSNVEGVKSAKPINGASSNGRLLNGGDCYDSDGGCSTDSSSAISHNSHNPNNNNNNTMNNINYNNNVNNCKRKHNDALDADFSLLKRRVKTTINNNIISDEKGASVAEDEQQRALAAAHRRQHQAAQHFACPVCIGSDFESMLMLSAHMDSEHCDIPAKCRHCDVVFHTHRQLNVHPCTNRQPRTPPRPKDLTYADFSSEKPPSVVDPSRQLFDCPKCGCTFRCANDLEMHVAECRAHSLHRIFHSAEYDFDRERFQQRTFKTRVASESSTGLDDGEAEEEDDDEEEDQHQQKQQQDNSEEFFKRLYLKHKADIHRQNACLSPQPSVDDRLDDMKFEEDCEKLQQQSHDSKDLADIQSILNMTSSSSTSNFLKNFEHSVNTPSSNYGMDKDEEEAQDAFTSEFRKMKLRGEFPCKLCTAVFPNLRALKGHNRIHLSAAGPSSPFRCNMCPYSICDKAALVRHMRSHNGDRPYECAVCNYAFTTKANCERHLRNRHAKTTRDEVKRAIIYHPSEDSSCEDPSKKLHLFSSPEIDDDVDLQYHQHHQPKDRSTPVSHLKEILTCEDGRSSKAMKIQVKSIDKLLDKSTASSSYNEVFREDEEEAEEERPLNASHHATDQTNHSPIDLSMDVLDLSKKPAKVSVPKEQPPCTLPAPTPAAPEGVTTSAPPTEDPKFDISVLEKNQQYLLAQQQLINEALPKIVDPSHYFQQLYRNLVFPPMNPINPFFLHNSFLPSNMTDLQKYAPLMSRMFAGSAPTSQMAAADSMKTHPPNPNSLSTSTLMPQASPLLSDKSSASSITSSPMSTNSMHPKPVATPTSSQSLNIPRHPGMQSTTLAGGPVKMVIKNGVLMPKQKQRRYRTERPFACDHCSARFTLRSNMERHVKQQHPQFYAQRQRSGHHIMRGRGASSAAAMNNITHLQAAIAAHNGNGVHVGPASISEQVKYAILAQQLKARKDTDLLQQALAHGSSSVAPGHLNLSPAGGLLPSQKDLNHLGLDHLNNSTVNGSLEEEDDPKLVIDEDDDCDESFMEDHDDGQYQEQGEGEVVNGSVNGHDLVGDKQKMQSPIEPANKSAKKVAETILEQAIKAGGSSSYNSNINSSLNASPQPAKTMKSMIAQAESVGKFLKEVASSPFKDESQDLVPVAKLVDNATTNAMSFNNYFRPSDVANHMEQSDEEGLVASGSASESNNSGTEDIASSAEPKKKSAYSLAPNRVSCPYCQRMFPWSSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNVESAVSVYVPAEDVNEPIPVPKSVEEIEQQQRQREEERKRKSEAEAARIEKERREKEQREQEEQERKETLKELAAAQFNQSTGQTSNVKAQDSAAASAAAYSELPFKCHLCDCSFGERFQCLDHIKAQHAQEFSLLLAKGAIDTDPDHNQVHSTEDEECRRPGEDSNGRCGKYPDYSNRKVICAFCVRRFWSTEDLRRHMRTHSGERPFQCDICLRKFTLKHSMLRHMKKHNGRHHSAGAGDLSNATNSGSDLSDDEQMSPTTPTNAIVMANTLAMRTHKIQELLNKANEWRTNRMSLGEHKENIGEEHNTQTDLIGNLLGISDQGILNKLLSSADEAAKLLGVEK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01023344;
90% Identity
-
80% Identity
-