Basic Information

Gene Symbol
-
Assembly
GCA_010645115.1
Location
WIUU01014439.1:1889-4646[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 6 0.0011 0.15 13.2 0.9 2 23 505 527 504 527 0.94
2 6 0.019 2.7 9.2 2.6 1 23 533 555 533 556 0.95
3 6 0.037 5.2 8.3 0.9 1 22 561 582 561 582 0.95
4 6 0.0043 0.6 11.3 0.5 1 23 596 618 596 618 0.98
5 6 1.4 1.9e+02 3.4 0.7 3 23 710 731 708 731 0.92
6 6 0.077 11 7.3 0.2 2 23 739 761 739 761 0.92

Sequence Information

Coding Sequence
ATGGAGGAAGTAACGAAATGTAGATACATCGATTGTGTCGACATACGGGAAAAGGAGCAAATACTTCACGAACTTCCCGTTTGCGATACCGGTCTCTGTGTGAGGTGGTTGATCAACAGTGGTCACGTGGACCTAATTGGGAGTGATCTCGATGCTTTACGGTCTATGAAGTTTTTCATCTGCAACAATCACTTTACGGAAGATTGCTACCTGAGCAAGGGCACTCTAAAGGAAAATGCAGTCCCCTCGCCGCATTGGAGCGCTGTTTCGAGGAcattgagaaatttgaaaatacgaCGCaaaatccAATTAAACGGGCAAGAAAGTTCTATGGAGAAGGTAAGCACGGATCAGCCTGCAGAGAAAAATGCTCCCTCAGAATTCGAAGTGGATCAATGGTGTAGAACATGCGCGACCAAGAAGCAGAACCTCGTAAGTATGACGACCAAGGGAAAAGGGACGGATATGAGCCTTCTgtcgaaattgaaacttttgatAGAAATCGACGACGAGGATGATTTACCTACGAAAATGTGCGACGAATGCGTCGACAAATTGGAACAGTCCTTCAAGTTTTTCCAACAGATTTACGTAGCAGACAATACGCTGCGCCATGTATTTCCAAGTACACGGTCGAGCAACGCACCTAGAAAACCTCTGCATTCGATAGGCGAGCATATGAGAAACGAacagaaggagaaggagaaggagaaagaacaaGAGGAagaacagcagcagcagcagcaacagcaacagcaacagcaacaacagaTTCAAGATCGTGCTCCAAAAGTGACACGTGGTATTTTTAGACGCGGTCGAGGCAGACCTCGCACCAGAGGTTACGCGGCCAGAGCAAGAGCTAGGCAAAGGTCTGCTCAAATGTCGGCGGCCTCGGTTACGAATACAGCTGGCAACGCCAATCTAAACGATAACAATAAGATAATttacgagagaagaagagcgAACGAAAGGTCCGTGTTGAAGAGCAAAGAAGCTCAGAGTGCGACGCACGACGAGGACGAAAGACAAGGCAACACGGTGTTTTCGTTGCTCACCGATACCTGTCACAGCGACGAAGAACTAGACTGGTCGGACGTGTTGAAAGTGATGAGCGATCAAAGATACAAGCACGTTGCTTCCACCAGACGAACGACGACGGAAACGACGAAACTGAAACTAAAACTGAACGAAGAAAACGTGCAAAAGAATAAAACGGAGGAAGAGAAgcaagaggaagaggaagaggagaagtTACGACAAGCGGAGAAGGCAACAACAGCGAACAACGTCGTGTCGAGAGCCGAAGCTAAGAGAGAAAGTGAAGCTAAGATGCAAACGAAAGACGAGATGGAAGAGACGACAGAATCAGTGGCGGAAGCAATGGCAGAATCGGAAGCAGAAGCAAAACCAGAAGCAGAAGCAGAAGTAAAGATGGAGATGGAAGCGGAGGAGGTGGTGATGCAGCCTAACGAAATGATGGCGAAATCAGCAAGAGAGACGGAGGAATTGCGTTGCGAGTTTTGCGACGAATCGTTTGAACTTCGACGCCAGTTACAGACACATTTGTCAAACAATCATTCTCAAATGTCCGGATATATGTGCGTAGATTGTCTAATTTGTTACGAAACGAAGCCGTTGCTCTTGAAACATCGTAATCTGCATCACGGAGATCGAAGGTATCGCTGCGAGCATTGCCAGCAAGAATTTCTCGAGAAAAGAGCACTGAGGGAACACGTAAGGAAATGCGAATCGCAAGCAGCTATTCTCGCTATCGCGGCCCGTTATTCTTGCGATTCGTGCGAGTCGACGTTCTCCTCGAAGCAACGGCTGATCGACCACGTCAACATTCATCCGGAAACGGATATGCCCGCAACGTTTCGCACGCAACAACAGCTCGACAACAATCCCGAGCCGGCAGCCAAGAATGAATTTCAGGCATCGTCTACTCAGTCCTCGGTTGCGCCTTCGAAAGACGCggtcgatgaaatttccatcacgTCGAATCCGGACGAGAAAAGCAGCGGCAGCGCGGTTGATTCGAGTAATTTATTCAAGGCCGACGATATAACGGAGGAAACGCAACAACGGTTGTTAACTAGTGGCGAGGAAGAATCAACGACGATTTGTCCAGATTGCAACGAGCAAATGCACGACACGGTGGAACTTAGCCTGCATCGGATGCGTCGTCATTCGATGAACAGAAAGGACGCGACCTGTCTCCTCTGCGACAACAAGTCCTTCTCCTCGTTGGACGAATACGAGCAGCACGTACTCGATCATTGTAAACGACTAAGAATATCACCgtaa
Protein Sequence
MEEVTKCRYIDCVDIREKEQILHELPVCDTGLCVRWLINSGHVDLIGSDLDALRSMKFFICNNHFTEDCYLSKGTLKENAVPSPHWSAVSRTLRNLKIRRKIQLNGQESSMEKVSTDQPAEKNAPSEFEVDQWCRTCATKKQNLVSMTTKGKGTDMSLLSKLKLLIEIDDEDDLPTKMCDECVDKLEQSFKFFQQIYVADNTLRHVFPSTRSSNAPRKPLHSIGEHMRNEQKEKEKEKEQEEEQQQQQQQQQQQQQQIQDRAPKVTRGIFRRGRGRPRTRGYAARARARQRSAQMSAASVTNTAGNANLNDNNKIIYERRRANERSVLKSKEAQSATHDEDERQGNTVFSLLTDTCHSDEELDWSDVLKVMSDQRYKHVASTRRTTTETTKLKLKLNEENVQKNKTEEEKQEEEEEEKLRQAEKATTANNVVSRAEAKRESEAKMQTKDEMEETTESVAEAMAESEAEAKPEAEAEVKMEMEAEEVVMQPNEMMAKSARETEELRCEFCDESFELRRQLQTHLSNNHSQMSGYMCVDCLICYETKPLLLKHRNLHHGDRRYRCEHCQQEFLEKRALREHVRKCESQAAILAIAARYSCDSCESTFSSKQRLIDHVNIHPETDMPATFRTQQQLDNNPEPAAKNEFQASSTQSSVAPSKDAVDEISITSNPDEKSSGSAVDSSNLFKADDITEETQQRLLTSGEEESTTICPDCNEQMHDTVELSLHRMRRHSMNRKDATCLLCDNKSFSSLDEYEQHVLDHCKRLRISP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01420576;
90% Identity
iTF_01419934;
80% Identity
iTF_01418397;