Basic Information

Gene Symbol
-
Assembly
GCA_951216915.1
Location
OX578242.1:2377385-2388113[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.03 2.3 9.5 1.1 1 23 239 261 239 261 0.96
2 16 0.081 6.2 8.2 0.1 2 23 290 312 289 312 0.93
3 16 0.017 1.3 10.3 0.2 2 23 333 355 332 355 0.94
4 16 0.00037 0.028 15.5 2.6 2 23 361 383 360 383 0.95
5 16 0.0031 0.24 12.6 1.0 1 23 388 411 388 411 0.95
6 16 0.043 3.3 9.0 0.3 2 23 414 436 413 436 0.95
7 16 0.0051 0.4 11.9 1.4 2 22 443 463 442 463 0.94
8 16 0.0034 0.27 12.5 0.6 1 23 523 546 523 546 0.93
9 16 0.012 0.96 10.7 0.0 3 23 575 596 573 596 0.94
10 16 0.21 16 6.9 0.2 2 23 619 642 618 642 0.94
11 16 0.0006 0.047 14.9 0.6 3 20 649 666 647 670 0.90
12 16 0.0096 0.74 11.1 0.4 1 23 675 698 675 698 0.97
13 16 0.0004 0.031 15.4 0.2 2 23 704 726 704 726 0.94
14 16 0.00014 0.011 16.8 4.7 1 23 730 753 730 753 0.97
15 16 0.00019 0.015 16.4 0.6 2 23 760 781 759 781 0.96
16 16 0.0021 0.16 13.2 2.2 1 23 787 809 787 809 0.98

Sequence Information

Coding Sequence
ATGGATTTCGACCACATCATGGTGAAAGAGAGCCCGGGGTTGTGCCGCTGTTGCCTCTCCGAGGGTTGCTACAAAGACTTGGGAACGGAGTATACTTGGATGAGCGATACTGAAGTTTATGCCGATATGCTGCTGGAATGCTTCGATATAAGCATAACCCAACACAATGAAGGCCCGAACGGCCCCAACCGTCTGATCTGCGAGGTTTGCATCACCAGGCTACGAGATGCATGCAACTTTAAGAAACAAGTCCTGGAGTCGGAGAAGAAGTTCATTGATATGGTGGGACGGGGGGAGTTTAGGCCAAAAGTGCTAATATACCAGGGGGAGATGAAAACTGAGGAGCAGGTTGAAGAGAGCATGGATGAACCTGAGGCGGAGTACCTGGAGGAAGACACTAACTATGCAGAtgACGATATTGCAAAAGATGAAGCTGAAGTAGAAGAATCATCAACGTATGAAGATATAACTGTATCAACATTACCTGTAAAGGGTAAACGAGGGAGGCCTAGGAAGAACGCGACCATTGTCAAGACTGATAAGAAAGCTAAAGTCTCCAAAATTGAAGAGAAACCCAAGACTTCAAAGGCTGTTGCTAAAGGTGTTAAATCGAGGAAATACAAGGGCAGCGAATCTTCCTCAATGCGGAGACGGAAAAACCTACAGATTCTGTTCAACAACACAACGATCATACCTTTTAAATGGCGCGGAAAGTATCTCTGCTTCTATTGCAGCAAAGATATAGCTGAGTATTCGGAGTTACGGAAACATACGAAATCGCACGGGAATTGTTCCACTAGAGATCACTCCTTAAAAGTTCTCAAAGGAGGCCaaaatatggaaataaaaatTGACGTTTCTGACGTCACTTgcgaaatttgtacggaaccattTCCTAATTTCGACGAGATCCTCaaccatttatttatcaaacataAATTAGAATATGACAGAACTGTCGATATGGCCATAGAAGAGTATAAATTACTTGATCTAAGTTGTCTTATATGCAACGAGAATTTCTCTTATTTCGGATATTTAGTTTCACACGTGAATAATATTCATCCGAAAAATTGCCTCATATGCGATAAGTGTAACCAGAAATTCAACAAGAAGAGAGATTTGTTCTCCCACATGAAGAATTATCATAGAGAAGGCGGTTATCAATGCGAATTGTGTCCACAAAGTTTTAGCTCCCTAAATATATTGCGGAAACATCGAAGCAATAGACATTTGACCCGTTGTACTATATGTCAGTTGAGGCTACCTTCGGCTTCTTTGAAACAAAAACATATGGAAATTGAACATCCCGATGACGGATGTCTACAATGCGATAATTgtgaaaaacaatttcatacAAAGCAAGGACTGAAAATGCATGTTAGAAAATGCAAGGCAGACGATTTCTTCGAACTAGCTATCAAGAAGGAAGATTACGGAGCGATGGATTTGGACGAAAACTACCAGGATACAGTTAAAAGACCCAGCGTGAAACAAATTAGAGAGAACATAGTAACAGTTATAAACATGTCGACGGCGATACCTTTTAATTTCTACAAgaataaattcaattgtttctatTGCTCAAAAGACTTCCCCGATTCGGATTCGATGAGAGAGCACACGGTTATGGAGCATCCAGTTTGTGATGTCAAAGAAAAATGTATCAGGAAATGTCGAGAATCGGTGGCATGTGTCAAAATTGACGTTTCGTCTTTAGCATGTAAAATCTGCTTTGAATCTGTAAGCGATTTGGAGAATTTACTGGATCaccttataataaaacatgaagCGAACTATGACAAATCTATAACAACATGCCTGCAGCCTTATAGACTAATAAAGGACCACATGGTATGTCCAAACTGTCCTGGGGAAGTTTTCAGATTCTTTGGAACGCTGCTCAAACACgtgaataaaaaacatacgAATAACAACATCATATGCGTTTACTGCGGACAAACTTTTAGACGCGATCAAAATCTGCGTGTTCATATTTGGAGGCATCATAGAGATGGGAGATTCAAATGTAACATCTGTGGAGCTGAGTGCAATATACCCTCAAGACTGTACATGCATATGGCTAAAGCTCACGGGGTTAAAGCGGCCAAATGTCCGAAATGCCCCGAATCGTTTGCCACGCAGTATTTAAGGCAAAAGCATTTGATAGAGGCACATGACTCAGGTCATAAATGTTCTTATTGCGGTAAATTGTTCACCCGAAACTCCTTCATGAGGGATCACGTCAGGAGGACGCATTTGAAAGAGAAGAACGTAGAATGTTCCATTTGTAACATGAAATTCTTTAATAATATTCTTCTGAGGCGGCACATGGTGAAACATAGCGGTGAAAAGAATTATCACTGTGATATTTGCGGGGAAAGATTCTTCTGGAGAAAAAGTCTTAGGACACACATGGCTAGGCATAATAAGCATTTGAATCcgatacaaatataa
Protein Sequence
MDFDHIMVKESPGLCRCCLSEGCYKDLGTEYTWMSDTEVYADMLLECFDISITQHNEGPNGPNRLICEVCITRLRDACNFKKQVLESEKKFIDMVGRGEFRPKVLIYQGEMKTEEQVEESMDEPEAEYLEEDTNYADDDIAKDEAEVEESSTYEDITVSTLPVKGKRGRPRKNATIVKTDKKAKVSKIEEKPKTSKAVAKGVKSRKYKGSESSSMRRRKNLQILFNNTTIIPFKWRGKYLCFYCSKDIAEYSELRKHTKSHGNCSTRDHSLKVLKGGQNMEIKIDVSDVTCEICTEPFPNFDEILNHLFIKHKLEYDRTVDMAIEEYKLLDLSCLICNENFSYFGYLVSHVNNIHPKNCLICDKCNQKFNKKRDLFSHMKNYHREGGYQCELCPQSFSSLNILRKHRSNRHLTRCTICQLRLPSASLKQKHMEIEHPDDGCLQCDNCEKQFHTKQGLKMHVRKCKADDFFELAIKKEDYGAMDLDENYQDTVKRPSVKQIRENIVTVINMSTAIPFNFYKNKFNCFYCSKDFPDSDSMREHTVMEHPVCDVKEKCIRKCRESVACVKIDVSSLACKICFESVSDLENLLDHLIIKHEANYDKSITTCLQPYRLIKDHMVCPNCPGEVFRFFGTLLKHVNKKHTNNNIICVYCGQTFRRDQNLRVHIWRHHRDGRFKCNICGAECNIPSRLYMHMAKAHGVKAAKCPKCPESFATQYLRQKHLIEAHDSGHKCSYCGKLFTRNSFMRDHVRRTHLKEKNVECSICNMKFFNNILLRRHMVKHSGEKNYHCDICGERFFWRKSLRTHMARHNKHLNPIQI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00013343;
90% Identity
iTF_01083579;
80% Identity
-