Basic Information

Insect: Tetanocera ferruginea
Gene Symbol: run
Assembly: GCA_958299015.1
Location: OY282643.1:4228550-4230352[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 5.4e-73 3.7e-69 231.7 0.0 2 129 61 188 60 188 0.99

2 2 3.1 2.2e+04 -3.6 0.0 34 64 332 362 315 364 0.69

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	5.4e-73	3.7e-69	231.7	0.0	2	129	61	188	60	188	0.99
2	2	3.1	2.2e+04	-3.6	0.0	34	64	332	362	315	364	0.69

Sequence Information

Coding Sequence: ATGCACCTGCCCGCTGGACCTACAATGCTTGCCACACCCGCTCAAGCCTTACCCATGAACAATACCAACAACGCCTCCAACAACACACGCTCCGCCAGCTCAACGGGCTCTTCAACACCGGACACCAACAGCAATTCCGCCAAGATGCCCTCCTCCATGACAGACATGTTCGCCAGCCTGCATGAAATGCTTCAAGAGTATCACGGTGAACTTGCTCAAACTGGCTCACCTTCCATACTCTGCAGCGCTTTGCCCAATCATTGGCGCTCCAATAAATCTCTGCCAGGCGCTTTTAAAGTTATTGCCTTGGATGATGTGCCCGATGGCACGCTGGTCACCATCAAGTGTGGCAACGATGAAAACTACTGTGGCGAGCTGCGCAACTGCACCGCGATCATGAAGAACCAGGTGGCTAAATTCAATGATCTACGTTTTGTTGGACGCTCTGGACGCGGCAAATCATTTACGCTGACAATTACCGTCGCTACTTATCCTGTGCAGATCGCTTCGTACACCAAGGCCATTAAGGTCACCGTGGATGGACCACGGGAGCCAAGAAGTAAGCaaaGTTATGGCTATCCACATCCCGGCGCCTTTAATCCATTTATGCTCAATCCTGCTTGGCTGGATGCTGCCTATATGACCTATGGCTATGCCGACTATTTCCGACAACAGGCCATGCATCACCCGGCTCTAGCTAAAGCTTTTCCAGGTGCTCAGAATTCGCCTGCTAATAATTCGTCACTAGTATCACCACCTGGCCCAGCCGCAAACGACTATCATCATTCGCAGATAACACCTCCACCTGCTGGCGCTCCACCTTCAACACTACCGCCAAACAGCGCTGCCGTCAACATGATTCCATCACCACCTGGCTCTGCTTATGGCATACCACAGTTCCCCTTCAATCCTGTAGCTGCTGCCgccgccgctgctgctgctgcctccACACATCCCGAACTGCTGCATCATCATCAGAAACATCCGCATGCCTTCCATCCGTATAACTTTGCCAACGCTGCAGGTTTGCGCGTTCGCAACGGCCAGCTGCACAATGTATCGCTTGGCTCCAATGAGCATATTAGTCCAGCCCACATTAGTCCCGCCTCATCACGTCCATCTTCATCGTCTCCACCTTCGCAACATGCTCTCAACAAGTTGAACACTTCGCTGGAGACCAACTCCATACACGAGCAATCTGCCTCCGATGCCGACTCAGATGATGAACAAATCGATGTCGTCAAATCGGCCTTTGATTTAGACAAGTCCATCGACTCGACATGCTCTTCACCACTGCAGACGCAGCAGCCACAAGCTCCACGTTACCGTTGCGAACTCAAGGCACCATCAACGTTGAAGCCACACTACCACGAATCATCCACACAATCACGTCAGACTTCACCCGAGACTACACTGTCCGCTGTCACCAAAGTCAAGTCTGTTAACGCTACACAAAAAACCGTCTGGCGCCCATATTGA
Protein Sequence: MHLPAGPTMLATPAQALPMNNTNNASNNTRSASSTGSSTPDTNSNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVTIKCGNDENYCGELRNCTAIMKNQVAKFNDLRFVGRSGRGKSFTLTITVATYPVQIASYTKAIKVTVDGPREPRSKQSYGYPHPGAFNPFMLNPAWLDAAYMTYGYADYFRQQAMHHPALAKAFPGAQNSPANNSSLVSPPGPAANDYHHSQITPPPAGAPPSTLPPNSAAVNMIPSPPGSAYGIPQFPFNPVAAAAAAAAAASTHPELLHHHQKHPHAFHPYNFANAAGLRVRNGQLHNVSLGSNEHISPAHISPASSRPSSSSPPSQHALNKLNTSLETNSIHEQSASDADSDDEQIDVVKSAFDLDKSIDSTCSSPLQTQQPQAPRYRCELKAPSTLKPHYHESSTQSRQTSPETTLSAVTKVKSVNATQKTVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_01180931;
90% Identity: iTF_01180931;
80% Identity: -