Basic Information

Gene Symbol
ken
Assembly
GCA_943736035.1
Location
CALSEY010000428.1:126670-128862[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 2.9 6.1e+02 2.6 0.3 1 20 231 250 231 251 0.91
2 10 2.7e-07 5.7e-05 24.7 0.2 1 23 384 406 384 406 0.97
3 10 0.0044 0.92 11.4 1.8 1 23 412 434 412 434 0.93
4 10 3e-05 0.0063 18.3 1.3 1 23 439 461 439 461 0.99
5 10 3.3e-05 0.0068 18.1 0.2 1 23 467 489 467 489 0.97
6 10 7e-07 0.00015 23.4 1.2 1 23 495 517 495 517 0.98
7 10 0.00028 0.059 15.2 0.5 1 23 524 546 524 546 0.94
8 10 0.00028 0.059 15.2 3.0 2 23 553 575 553 575 0.97
9 10 0.00024 0.049 15.4 2.2 1 23 581 603 581 603 0.98
10 10 1.5e-05 0.0031 19.2 2.1 1 23 609 632 609 632 0.94

Sequence Information

Coding Sequence
ATGCGTGAAAATAACGATATAAATAACACGTGTCGCCTGTGTTTGGCCAAAATCGATGAAACACAATTCACCAAAATCTATCCTCAAACTTATCTAAACGGCGTTTCACTAGTTATGAAAATCATGGTCTGCGTGTCATTGACAATTCAGGAGGACGATCCTTTCCCAAAAAAAATATGCAGAAATTGCGAAGAATCTGTGAACTCGTTTTATTCATTTCGCGAGACTTGTTCTAGGGCCTATTTCATCCTTATACAAAATTTTCGAGAGTCCAAAGACCCCGTTGAACAGTCTGAGTATCGTGAATCTGACGCAGAATCGTTACTAGAAAGAGAAAAGGAAACTAACAACGAGCACAAAAGACGTAACGACGATTTTGACCTAGAACAAAACATTCCTGAACATCATATCATGTGTCTGGACACGGATAATCGTTCTATCAAATTAAGGAAAGAATCGATTTGCGAAGAGAGTCTATTCTCCATAAACAAATTGCCCCAAGATTCTGAAGTTGATCTAAAGACTCTACAGAAATCTAAAGAAGATCTTTCTGAAACGGTCGAAGAATTTGATTCGGCTGTGGTAAAGGGAGATGCTCTAACTGGTTGTAACGTCGAAGTAGATTGTTATCAAGTTGAAGAAATTAGGGAGCAAATACTATGCGGTAAAGAGGTCGAAGAACGAGTTAGATACAAATGTTTAAGATGCGAGAATAACTTTGACGATTTAGACTCGGTCACTGGACATTATACAGATTATTGTCAGCCGGTTGATTACCAAGAAGCTAAATGGGATTCAGCTGGTTCTAACGACGGAGAGGAGAGAACAGATTATTTGGACTCCTTCGAATATTTGGATGGGAGCTTTGAGCTGGATACTAAGGAGACAACGAGCGTAGAATATTCGAATAATGATAACGTCGCGGAAGATGTTGATTCTGCTAATCATTTAGAGATAAATGAAGAGAATCATTGCGCCAGAAGAAATTCAACTCCAAATTTTGATTCTACGAGTTCTTGTAATTCAACAGCAGCTACAGAAAGCTTCATTTTGGTATCGAAGAAATCCTGCGATTCAAAGACGGAAGAAAATTTGCCTATTAGGGCGAGGACGAAAAAACGGAAAGGTCGTTGGCTGGGAAAAATGGAATATCCTTGCCCGGAATGCGATAGAATATTTACTAGTAGTTCTTTGCTCAAGAGACATTCTATGGTTCATACAGGAGAACGACCTCACATATGCGAAATATGCGATCGACGTTTTGCCCAGCTAGGACAGCTGAATTTTCATAGAAAGTTTCACAACAATCCACGTtatcgatgccatatttgtagtaaacctttcctgagaccgagtgacattgagaaacatgtgcggactcatacgggggagaaaccatacgattgtaaaatatgtttgaaatcgttcgcccaattaggagccttgcaacaacattcgagaattcattccggcgagaaaccatactcatgtgaaatatgtgggaagagattttctcaaaaagcaaataagaccaagcacgTCAAGATACATAAGGAAGGGGAAAGACCTCATACTTGTTATATCTGTGGACGTAGTTTTTCTGAATTATCTGAAATGGAATTGCATAGAGCAGGTCACGGCGGAGGTAGACCTAGAAAGTGTGATTACTGCGACGATAGCTTTAGAAAATTATCGGAATTAAATCATCACGTAAGGCGATTCCACACCTTTGAAAGACAGCATAAGTGCATGTTCTGCCCAAAGGAATTCTACTCGATATATAATTTGAAACAACATGTAATGGTGCATACGGGTCAAAGACCTTATGCTTGTTCAAAGTGTGACCTTAGGTTTACACAGAAAGGAAATCTCACAAAACACTTTGAGAGAAAACATTCAGAGTTTGTAGAAAAAAAGGATCGCTATATTATCGTTGATGAAAAATCATTCGACGGTGATAATTTGTCATTTGTTGAGAAAATCGGGCATGAAGATGATACAGAGGATCACCTAATTGTGGAAAGAGAAGAGACAATAGAGTCGGAAGCTGATACTAGTTTAGAAAGGGATTGTGCGTAA
Protein Sequence
MRENNDINNTCRLCLAKIDETQFTKIYPQTYLNGVSLVMKIMVCVSLTIQEDDPFPKKICRNCEESVNSFYSFRETCSRAYFILIQNFRESKDPVEQSEYRESDAESLLEREKETNNEHKRRNDDFDLEQNIPEHHIMCLDTDNRSIKLRKESICEESLFSINKLPQDSEVDLKTLQKSKEDLSETVEEFDSAVVKGDALTGCNVEVDCYQVEEIREQILCGKEVEERVRYKCLRCENNFDDLDSVTGHYTDYCQPVDYQEAKWDSAGSNDGEERTDYLDSFEYLDGSFELDTKETTSVEYSNNDNVAEDVDSANHLEINEENHCARRNSTPNFDSTSSCNSTAATESFILVSKKSCDSKTEENLPIRARTKKRKGRWLGKMEYPCPECDRIFTSSSLLKRHSMVHTGERPHICEICDRRFAQLGQLNFHRKFHNNPRYRCHICSKPFLRPSDIEKHVRTHTGEKPYDCKICLKSFAQLGALQQHSRIHSGEKPYSCEICGKRFSQKANKTKHVKIHKEGERPHTCYICGRSFSELSEMELHRAGHGGGRPRKCDYCDDSFRKLSELNHHVRRFHTFERQHKCMFCPKEFYSIYNLKQHVMVHTGQRPYACSKCDLRFTQKGNLTKHFERKHSEFVEKKDRYIIVDEKSFDGDNLSFVEKIGHEDDTEDHLIVEREETIESEADTSLERDCA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00939842;
90% Identity
iTF_01414436;
80% Identity
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