Basic Information

Gene Symbol
topi
Assembly
GCA_004794745.1
Location
QBLH01003535.1:62807-68495[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 0.0017 0.13 12.3 1.6 1 23 494 516 494 516 0.93
2 16 0.13 9.8 6.4 1.1 2 23 523 545 522 545 0.95
3 16 0.0044 0.34 11.0 0.1 2 21 552 571 551 572 0.92
4 16 0.00051 0.04 13.9 1.0 1 23 579 601 579 601 0.96
5 16 1.1e-06 8.6e-05 22.3 2.2 1 23 607 629 607 629 0.98
6 16 0.022 1.7 8.8 0.2 2 23 641 663 640 663 0.94
7 16 0.0039 0.3 11.2 8.4 1 23 679 701 679 701 0.98
8 16 0.59 46 4.3 0.2 1 23 707 729 707 729 0.93
9 16 0.34 26 5.1 1.1 1 23 739 762 739 762 0.92
10 16 0.067 5.2 7.3 0.0 1 21 776 796 776 797 0.92
11 16 0.0049 0.38 10.9 0.1 1 23 802 824 802 824 0.98
12 16 2.2e-06 0.00017 21.4 3.1 1 23 830 852 830 852 0.98
13 16 0.00014 0.011 15.7 0.3 1 23 858 881 858 881 0.97
14 16 0.052 4 7.6 0.7 1 23 887 909 887 909 0.88
15 16 7.8e-07 6.1e-05 22.8 2.1 1 23 915 937 915 937 0.99
16 16 9.3e-06 0.00073 19.4 6.3 1 23 943 966 943 966 0.97

Sequence Information

Coding Sequence
ATGGCATCATCCATCTGTGACATCAAAAAGGACAGAAAAGTGACCAAACTGCAAGTTATGATTGACGAAAATAGACTTACAAAACAGAATGAAAACGATAATCTGgaagagataattaataagcAATTCGAGAAACTTCTGGAACTCAACAGCGCCACAGTGTTAATAAAAGGCAAGCAAAATATAAAGGATGAACTTCAGAGAGTGCGCGAGGAAGTATCGCAACTTGGATGTGGCATCAACGAAATGAAAAATCAGTTGAAAAGAATGAGAGAACAGAATTGTCGTTCAAGGGAATTATTGAAGTTAGTTGAAACTTTGGACAAAAGAATTCTCCACCAAGAAAAGAATGTTCCACCCGAGCTCATACAAGGCTACCAGAATGCAAAAATCTCTCCTAATATGTTAGGGTGTACTGTAAATTCAACGCACCAACTGTCGGAACAAATGCCGAGTAGCACCAAAAGGATTGAAAAGCAAGAAATTGTGAAAGATTGTAAAAGAACGCTTTTCAACGAACCAGAAATATGTCCAACAATATCATTTATCACtgaagaagaattaaataaagtaccCAAGTATATGATCGGGAGGCAAACAAGTAATACCTTGGAGacaattaataactttataagtGGTATAAATCAGACATTAATTGCGAAATATACGATTTTATCGTTGGGGAAGGCTGCCGCTCAAAAAAAGGGTGAAATTAATCtgtatttacattataaaaagcaGGAACTCGATATCCAAGAAGAAAATCAGTCAATTAGTACATTAAGTGGCCATGAAGATGATATTGATGATTTGGATGGTTCTGTGATATGGTCCCAAGAGGAGCCACTTTCTTCTAACGAGATATTGGAATTATCGGCAcaagatgaaaaagaaaacagctTATTTGCTTTCTGTCGATTGTGTGCTGGTCAAACCACTAacccaatatatatttattctgagTTTGGAGAATCAATGAAATTggcacataaaataaatacgtgtCTAagcattaaaATTAAGAAGACAGACCCATTACCGAAACAGCTCTGTTTGACCTGCGTCGAGAAAGTAAACTGGTGCGACGAATTTGACACACAATGCATTAAAGCGGAGGAAATCTTGTCAACGATGTTAAAGGAGAAgcaatcttttaatatttctaatggATTGTTTTCCGACCAACAATCCTGTCCTTTATGCGTAAAGGGCTTTATGAATGTATGTAAAGAAACATTCCAGAATACAAAGGACATGGAATTATACgagaatgatataattttagaaagcAGTGATGAGgagaacatatttaataacgcAAAGGTCAATAAGGAAAACGGGAATCGTTCTATCACATTACAATGCCTAGGAGATAGACAGACATATCTAAAGTGTGGAGCGTGCATGAATCTCTATCACACCGAGGAGACACTAGATGGTCATAAATGTAAACCCAGTATACAGAACACAACGAAGCCATATAAGTGTCCCATATGCGACAAGACATTCATGTTCGAAGAACGATTAAACTTTCACATGCAATTTCACAAAGGCGCGAAAGCATTATACTGCGAGGTCTGTAAGATAACGTTCGGCAAAGAATTGAAGCTATTTTACCACTATAAGAGACAACATTCTAAGGAGAATAGCGTCTCATGTCTGCAGTGTGGAAAGTTATTCGAGGATCAGGAGGCGCTCCGAGTGCACGTTTGCGTCGACGGTAAGAATCGGCCTCATATTTGCGAAGTGTGCAATAAAGGCTTTTTCGACGGTTACACTCTGAAGCGTCACGTAGTGACGCACCTGCCTGAGAAGCCTTACAAGTGCTCGGAGTGCTCGAAGAGCTTTACGCAGAAATCAAGGTTGAACAAACATGTCGCGAGCCACTGCATAGTTATCGAGAACAGCCAGACGGTCTGGAAATGCCTTCAGTGCGGTGAAGTGTTTATCTCTTGCGATGATGCAGATATTCATTACAAGATAATACACGAGGACAAAGTCACGCTGATCGAGGAGTTGCTGACATCGAAACTGTATCATTGCGAGTTTTGCAACAGCCATTTCACCAACGCGGACAATCTGAAGACTCATCAGAAACATCATGTTGTCGAAAGACCCTATACGTGTAATACATGCGTGGCCACTTACAGATCCTTCGCGGAAGCTGTTTTACATTGGAAGGAACATCCCAGGCTGTTTAAAGTTCTCGTCGTCTTTCTATGCGAGGTCTGTAACAAGGACATGAAGGAATTATCCCTGCTGTACAAACACAAGCAAAACAGACACGCCCGCGCGTCCAGATTGTCCGAGTCGGGCGACGCGAAGTTCATCTGCGAACTCTGCGGAAGTGTGTTCGACAAAAGCGAGGATGTACAGGATCACGGACGAGATCAATGTTCCAAGTTTCCCTGCGACATTTGCGGCAGCCTGCTGCCCACGGCGAACTCCTTGAACGCGCACAAAAGACGGCACAACGGATTGCGGCCGTACGTCTGTAACATTTGCGGAAAGAGTTACACGCAGTCCAGTCACATGTGGACCCACAAGAGATTCCACATGGGCATCAAGCCTTACGCTTGCGAGTATTGCGATCAGCGTTTCACGATAAAACCGGACTTGGCGGATCACGTTAGGAAGAAGCATACGAGGGAGAGGCCGTTCAAGTGCGAGGTGTGCAACAAGGCATTTCTGACCGGGTCTGTGTTTTATCAGCACAGATTGATACACCGTGGCGATCGCAGGTACAAGTGCCATTACTGCGAGAGGGCCTTCACCAGAACGGAGGCCTTGAACAACCACATCAAGATACACACCGGGGAAAAGCCGCACTCGTGCGATGTGTGCGGCAGATGCTTCAGACAGAAAGGAGACATGAGGAAACACAGACGCACCAAACATGCCTCCGAACAAGATAAATCAATTGAGAATTGTCAGAATTAA
Protein Sequence
MASSICDIKKDRKVTKLQVMIDENRLTKQNENDNLEEIINKQFEKLLELNSATVLIKGKQNIKDELQRVREEVSQLGCGINEMKNQLKRMREQNCRSRELLKLVETLDKRILHQEKNVPPELIQGYQNAKISPNMLGCTVNSTHQLSEQMPSSTKRIEKQEIVKDCKRTLFNEPEICPTISFITEEELNKVPKYMIGRQTSNTLETINNFISGINQTLIAKYTILSLGKAAAQKKGEINLYLHYKKQELDIQEENQSISTLSGHEDDIDDLDGSVIWSQEEPLSSNEILELSAQDEKENSLFAFCRLCAGQTTNPIYIYSEFGESMKLAHKINTCLSIKIKKTDPLPKQLCLTCVEKVNWCDEFDTQCIKAEEILSTMLKEKQSFNISNGLFSDQQSCPLCVKGFMNVCKETFQNTKDMELYENDIILESSDEENIFNNAKVNKENGNRSITLQCLGDRQTYLKCGACMNLYHTEETLDGHKCKPSIQNTTKPYKCPICDKTFMFEERLNFHMQFHKGAKALYCEVCKITFGKELKLFYHYKRQHSKENSVSCLQCGKLFEDQEALRVHVCVDGKNRPHICEVCNKGFFDGYTLKRHVVTHLPEKPYKCSECSKSFTQKSRLNKHVASHCIVIENSQTVWKCLQCGEVFISCDDADIHYKIIHEDKVTLIEELLTSKLYHCEFCNSHFTNADNLKTHQKHHVVERPYTCNTCVATYRSFAEAVLHWKEHPRLFKVLVVFLCEVCNKDMKELSLLYKHKQNRHARASRLSESGDAKFICELCGSVFDKSEDVQDHGRDQCSKFPCDICGSLLPTANSLNAHKRRHNGLRPYVCNICGKSYTQSSHMWTHKRFHMGIKPYACEYCDQRFTIKPDLADHVRKKHTRERPFKCEVCNKAFLTGSVFYQHRLIHRGDRRYKCHYCERAFTRTEALNNHIKIHTGEKPHSCDVCGRCFRQKGDMRKHRRTKHASEQDKSIENCQN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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