Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2.7e-05 0.002 19.0 4.6 1 23 151 173 151 173 0.99

2 6 2.2 1.6e+02 3.6 0.1 1 9 179 187 179 197 0.73

3 6 4.2e-06 0.0003 21.6 0.5 1 23 204 228 204 228 0.97

4 6 0.00024 0.017 16.1 2.7 5 23 237 255 234 255 0.95

5 6 0.0027 0.19 12.8 0.2 1 23 261 282 261 282 0.91

6 6 8.6e-05 0.0062 17.5 5.0 1 23 305 328 305 328 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2.7e-05	0.002	19.0	4.6	1	23	151	173	151	173	0.99
2	6	2.2	1.6e+02	3.6	0.1	1	9	179	187	179	197	0.73
3	6	4.2e-06	0.0003	21.6	0.5	1	23	204	228	204	228	0.97
4	6	0.00024	0.017	16.1	2.7	5	23	237	255	234	255	0.95
5	6	0.0027	0.19	12.8	0.2	1	23	261	282	261	282	0.91
6	6	8.6e-05	0.0062	17.5	5.0	1	23	305	328	305	328	0.97

Coding Sequence: ATGGATGGAAAAATATGCAGGATATGTTTACAAGACAAGAACCAACTACATCAAATATTTGAAAAGAACAAAGATTCATTACTCTCTCCTTATGAAAAGCTTCAACAACTAAAGCTGATAGAAATTTCTGTTACCAGCTTATCTTCAATATGTCGCCTCTGTCTTGTTGAACTAGATAATTGTGTGAAGTTCTTTCAGAAATGTGAACAATCAAATAAGATTCTTAGCTCAATGTACCCTACTCAGGATCAAAATATATTGATATCCTCAGGCAACCAGATAGCATATTTAGATGATCAATCAGATAATAAGTTTCCAGATGATTCTGACATTATAAAAGATTGTGAAGAACTTTCGGATCCTGAAGAAATTGTGCAGGATGATTTAAGCAGCGAACCATGTATAAAATGTGATGTAGAGTGCAACTGTACACATAAAGCTTCTACTGAGTATACTTGTGAGATTTGCCAAAAAATCTTCACTAAAAAATTTAATTATCACATACATATAAAAAGGCATTTAGGCATTCGCGAATTTCCTTGCCCTACATGTGGGACTGCCCAAGTGTCGAGCTGGCTAGCCAAGCGTCATTGTGAAACAGGGCCCAACTACCCCTGCCCCGCACCCAACTGCTTTAAATCATACACCTCTGCCCATAATCTTACTGTCCACATTCGCAATCACACAGGAGAAAAACCGTATAAGTGTCATTGTGGACAAGGATTCACATCAAGATCATCACTGAACAGCCATGCTAGAACACACACAGGTGTGAAGCCGTACATGTGTTCGATATGCGGCGCTCGCTTCGCCACCAACAAGCTGGTCGCTCACCTGCGCACGCACGCGCAGAAGCCGCGCGACCCGACCCGACCCAACTATACTAAGATCACTAAGGTCGACCAGAATGGGTTTATCTGCACTTACTGCTCGACGCGCTACTCGCACAAGCAATCACTCAACAGGCACGTCAGGAAACAACACGCCGACTATCTGGCCGAAACAGATGAGGCCAATGATGAAATTTTGGATATCAACATTATTAACAGTGAAAGTCTAGTATAA
Protein Sequence: MDGKICRICLQDKNQLHQIFEKNKDSLLSPYEKLQQLKLIEISVTSLSSICRLCLVELDNCVKFFQKCEQSNKILSSMYPTQDQNILISSGNQIAYLDDQSDNKFPDDSDIIKDCEELSDPEEIVQDDLSSEPCIKCDVECNCTHKASTEYTCEICQKIFTKKFNYHIHIKRHLGIREFPCPTCGTAQVSSWLAKRHCETGPNYPCPAPNCFKSYTSAHNLTVHIRNHTGEKPYKCHCGQGFTSRSSLNSHARTHTGVKPYMCSICGARFATNKLVAHLRTHAQKPRDPTRPNYTKITKVDQNGFICTYCSTRYSHKQSLNRHVRKQHADYLAETDEANDEILDINIINSESLV

Sequence clustering based on sequence similarity using MMseqs2