Basic Information

Gene Symbol
-
Assembly
GCA_948473455.1
Location
OX419609.1:305221-325232[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0017 0.12 13.4 1.7 1 23 264 286 264 286 0.97
2 11 0.00095 0.068 14.2 4.0 1 23 293 315 293 315 0.98
3 11 1.7 1.2e+02 4.0 0.3 1 10 319 328 319 341 0.70
4 11 0.0002 0.015 16.3 1.3 1 23 346 369 346 369 0.97
5 11 0.33 24 6.2 0.1 2 23 373 395 372 395 0.89
6 11 0.97 70 4.7 0.3 1 19 400 418 400 420 0.85
7 11 0.0058 0.42 11.7 0.8 3 23 431 452 430 452 0.95
8 11 0.00035 0.025 15.6 0.3 1 23 459 482 459 482 0.94
9 11 0.029 2.1 9.5 2.0 1 23 533 555 533 555 0.96
10 11 5.9e-06 0.00042 21.1 1.7 1 23 561 583 561 583 0.98
11 11 0.024 1.7 9.8 1.2 1 20 589 608 589 610 0.93

Sequence Information

Coding Sequence
ATGGATGTTTGGGACCCATTGTCATGCCGTGCTTGTCTAGTAACTGATGTGAAACTGTTCCACCTACATGACACTGGTTTAGCCGATCTATTCGCCCTCATAACTGATTCCCCTGTGTTACCAGCAGACGGCCTCCCTCAGTCTGTGTGCTACTATTGTTATGCACAGTTGATCAAAATAAAAAAATTCCGTCTAAAATGTCAGAAGACTATGACCTATTTTCATGATATGGTATCAGCTGGTTTCGTTGAAAGTTTTGACAAAATCAAACACACCATACCTCTCACTTGTATTGAAAATGTTAGCTTAGATATATTACCCACTGATGTAGACGAATATGCATTATTTGTTACAAACATTGATACCTTTAATGGTAATCCCATAGAAAGTATTGACAATGATGACAATGGTGATGTTAATGATCATTATATGGAAATAGACGATGAGATAAAAGTGAAAGAGGAAATAGATATTGAAGAAGTTGATATAAAGTTTGAAATAAACCAAAAGAATGAAGAACATAACATTTCAGTTTCTTCACACAATTTGACTGAAGAACTTGAAGCAGCAAAAACGCTAAAAGCTAAAAGAAAAACGAAAGCTATCGAAAATAAACCAACAGTGAAGGCGCCTCCGAAAAAGAAAGCTAATAGATATAATCAGAAATTCGAAGAAGAGCTAGCTGATTTCGCTATTAAACACAATCTTAAAGTTGTTTGTCTCTCCAGAGAGGATCAGTTGCAACAGGTTGAGGATCGGAAGAACAGTGAAGGGTTCAAAAATAGTAGGTTTCCTTGCAACGTTTGCTATAAGTGGTTCAGGTCTGAAAGTGCTTATAATCATCACATGAAAGGCCATGATTTGAGTGACGGCTCTTTCGTGTGCGACATCTGTCAGTTGCACTTCAAAACGAAGTTCGCTATGAACAGCCACAAGCGAAGGCACCGGAAGCAGTTTGTATGCAACATCTGCGGGCAAGTCAACCGAACCACCCACAGGGCAAAGTTACACTGGGAGTGGCATGAAGGAGTGCAGTTTAAATGCACGGAGTGTGGCAAGTTGTTCAATGCTAGCTCCACTTACATGAACCACACCCGGGAGAGCCACAGGGCTGTGTCGTGTGCAGACTGCGGGCAGAGCTTCCTCGGTACGAACGAGCTGCTCGAACACACTAACGTCCAACATGGAAATATGAAGTTCAAATGTGAAGTGTGTTCAGTCGCGTTCCAAAGCCCCGAAGCCTGCGTTCGCCACAGAGCCGATAACGTCTGTCACGGGAAAAACAACCCGTGTCGGCATTGCGGCGCCAACTTCCCACTAAAGACGGACCTTCACGCTCACATCGCTAAGGAGCACACAGGGAACGGAGGAATGTTCACTTGTGATCAGTGCGGTGCATTATTCTCGTCGGAGCGCAACCTGACAGCCCACGTGAGCTACAGCCACACGCGCCACGTCAAACACCACTCCCCCCGCGTGTCCATCCCCGCCGCCCCCCCGCCCAAACCCCTCCGGATCACCGCGGAGTTGGCCCACGATGACATCAGAAAACGGACCACCAAGGCCAAGATGAGTAAAGAAGATGCGTCGGCTGTTTACCTTTGTGAAGTCTGCGCTAAGAGCTTTACTTGCCCAACCAAGTTTAAGGTGCACGTACAGACGCACAGCGACCTCAAGCCCTTCCCCTGCCCGGTCTGCGGCAAGGGCTTCCATTTCAAGAGCACCTTCaagATGCATATGAACATTCATACTGGCAACAGGCCATTCAAATGCAGGCTGTGTCCCGAGGCGTTCAAATCTTACTCGCAGCGATACAAACACAAACTATTGGTGAGTGATGTTACAGTACACTCAGAACAGTAA
Protein Sequence
MDVWDPLSCRACLVTDVKLFHLHDTGLADLFALITDSPVLPADGLPQSVCYYCYAQLIKIKKFRLKCQKTMTYFHDMVSAGFVESFDKIKHTIPLTCIENVSLDILPTDVDEYALFVTNIDTFNGNPIESIDNDDNGDVNDHYMEIDDEIKVKEEIDIEEVDIKFEINQKNEEHNISVSSHNLTEELEAAKTLKAKRKTKAIENKPTVKAPPKKKANRYNQKFEEELADFAIKHNLKVVCLSREDQLQQVEDRKNSEGFKNSRFPCNVCYKWFRSESAYNHHMKGHDLSDGSFVCDICQLHFKTKFAMNSHKRRHRKQFVCNICGQVNRTTHRAKLHWEWHEGVQFKCTECGKLFNASSTYMNHTRESHRAVSCADCGQSFLGTNELLEHTNVQHGNMKFKCEVCSVAFQSPEACVRHRADNVCHGKNNPCRHCGANFPLKTDLHAHIAKEHTGNGGMFTCDQCGALFSSERNLTAHVSYSHTRHVKHHSPRVSIPAAPPPKPLRITAELAHDDIRKRTTKAKMSKEDASAVYLCEVCAKSFTCPTKFKVHVQTHSDLKPFPCPVCGKGFHFKSTFKMHMNIHTGNRPFKCRLCPEAFKSYSQRYKHKLLVSDVTVHSEQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-