Basic Information

Gene Symbol
-
Assembly
GCA_948473455.1
Location
OX419604.1:5614617-5627443[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 2.7e-05 0.0019 19.0 1.5 2 23 262 283 261 283 0.97
2 13 0.027 1.9 9.6 1.9 1 23 291 314 291 314 0.94
3 13 1.8 1.3e+02 3.8 0.9 1 23 318 341 318 341 0.90
4 13 0.0013 0.095 13.7 1.4 1 23 417 439 417 439 0.99
5 13 0.012 0.88 10.7 1.6 2 23 448 470 447 470 0.95
6 13 1.1 77 4.6 4.5 1 23 474 496 474 496 0.98
7 13 0.00098 0.071 14.1 2.4 1 23 501 524 501 524 0.98
8 13 0.14 9.9 7.4 1.0 2 23 529 551 528 551 0.87
9 13 1.1 78 4.6 0.3 1 20 570 589 570 591 0.93
10 13 0.21 15 6.8 1.4 3 23 638 659 636 659 0.95
11 13 4.8e-06 0.00034 21.4 1.2 1 23 668 690 668 690 0.98
12 13 0.001 0.075 14.1 0.8 3 23 698 718 696 718 0.96
13 13 2.1e-05 0.0015 19.4 2.5 1 23 724 747 724 747 0.98

Sequence Information

Coding Sequence
ATGTGGGATTTAAAAGCGTGTGCAGCGTGCTTTAGCACGAAATGCGTTTTATATAAATTGGACAAAGGAACCTTGAAAAAGGAGTATTGTTTGCTCGCCGGACTGAAGTCTGATGACATGTCTGGCTTACCTCAATATTTGTGTGTGGAGTGCACAGCATATGTGAAGAAATTTGTAAAATTTAGAGACAAATGTAAAAGGGCTCATTTTGTTATGAAAGAGCTCATACAAACAAACAGGCAGATAAGTCATGTTACACTTGAAGCAATAGACCGTAAAAGCTTGAATATTGCGCCTACAAGATCTTACCTAGAGCTGAATAAAACACATTACGAATGTAGCCAGTTTACTTGGGAGAAGGATGTCTACAACCGTGGCAGTGTTGCTGCGATACCATCAGAACAAACAATTCCTGTGTTTTACTGCAGCACTGTAGCCTTAGAATGTGAATTTGATATTCCTAGCAAAAGACCTAGAATGTCAGACTCAATAAAGCTGGAGGTTGAGGAACATCCCAGTGAATTTCAAGTAGAAATGATTAATGATGTAACTCAAAGCCATCTGGTGCCATCAACGTCTATGCCTATAGAGAACTATTTAATGGACGAACATTACGATGATGATCAGGGAACTGAAAATTTTTCATGCAAAGATGAAAATTTTGAAGCGGAGCCTATAGATGGAACTAATATGGAGGAAGAATATGCCACGTTAGTGCCAATATCAATGAAAGAAGCTAGAGCAGCTCTAGAAATTTTCACAAAATATAGGAGAGGCGATTTAATGTGTACAATTTGCAAAAAAAAGTTTAATAATCAAACTCTTTTCGAAGTCCACCTAAGGATGCATGATCAGCACACAAGTGGCAACTTCCAGTGTGTGTTGTGTCAATTGTTCTACAAGACTGAGTTCTTATTGAAGACTCACATGACTGATAAACACATATACAAATACATTTGTAAGAAATGTCCGGAGGTCAACTTTGATAGGTCATCAGCCAAAAAGCACTACATTTACACACACCTTGACCTTGGTCACAGAAAGGCAGGCAACTTGTATAACGAGTTGCGGCCGTCTTGGCTTCGCAAATCAGGTATTGCCCGCCCTCAGAACACCTCAAAGGTTCGTCCGGGACGTAAAGTGGTAAAGCTACCTGAAGACTTCCTCATGTACAATCCGGTCAGCCAAGAGGAACAATACCGCTTGGTGCAGGAGAGGAAAACCACTAGGAACTACCAAGAAGCGACTTACAAATGTGAATTGTGTTTTAAAGGATTCAGAGAAGCAGTTACTTATGGAAAACATATGAAGAAACATGATCCAGCGATTTCGGGAAATCTTCAGTGCGATATGTGCAAGCTACACTTCCGAGACGCGCGCAAAGTGTACAAACACATGATCATCACACACCTGTTCAGATATTCCTGCCAAGTGTGCAACTTTGTGTGTTTCAACAAGGGCCAAGCGCATATGCACTACAGATGGCACAAAAACGTCACATATACCTGCGAGTTCTGTAAGAAAGAATTTAAGAAAGCGTCGACGCGGCTGACCCACATTAGAATAAAGCACCCGTCGACCATCGTCTGTGATATTTGCGGCCACAGCTTCGTGAGCGAAAACGGACTCTATTGCCATAAGAAGATAGCTCATAGTAAAGAGGAGCTAGAGTCGAGTGCGGCGAAGCAAACGGATCCATTACACCCGCACTACTGCGCAGATTGCGATGTTCAGTTCCAGTCCGTCACCGCGTACAAGACGCACCTCGGCAGCTCCAACAAACACGCATCTACCAACCTGTCAATCAAGCCGGTGCGGCTGTCGCGGCCGAGCGGGGCCGCCAAGAAGCCGGGCCGGCCCCGGAACGGCTCCTCCGAGATCGTCAACACCGGGGTACCCACCGCCAGCCACTGCGAGATCTGCAACAAATTCCTGACGAACGATGTGCAAGCGCGCAAACATTACGAGACGGAGCACCCGGGGGCGGAGTTCCCCAAGCGGTACATGTGCGACGTGTGCGGACACACCACCAGGCAATACGCGAACCTAATGGTCCACATGCGAACACACACACAAGAGAAACCCTACGGCTGCCCGCACTGCGACCGCCGCTTCAGCATGCCCAGCAACAGAGACAGACATCTCGTTGTGCACACTGGCGAGAAGAAGTACCAGTGCCAGCACTGCTCGCGGCGCTTCACGCAGTCGTCCGCCGTGAAGCTACACATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCAAGCGGCGCAAGGTAACACACCACACTGTTCAAGAAGTACCAGTGCCAGCACTGCTCATACAGACCGTGCACCTCAAGATACCCTACGCGCCCTGGGACAAGAAGAACCGCACAAGGCGCAAGGAGATGGAAGGCGGTCCTCCAGTAAGCGCCCCCCCGCTCCCCGCGCCCCCCCCCAAGCTGCTGCTCGACGCGCAAGGGGATTACCTCAACGCCTACATCACCTACAGCGACGAGTAA
Protein Sequence
MWDLKACAACFSTKCVLYKLDKGTLKKEYCLLAGLKSDDMSGLPQYLCVECTAYVKKFVKFRDKCKRAHFVMKELIQTNRQISHVTLEAIDRKSLNIAPTRSYLELNKTHYECSQFTWEKDVYNRGSVAAIPSEQTIPVFYCSTVALECEFDIPSKRPRMSDSIKLEVEEHPSEFQVEMINDVTQSHLVPSTSMPIENYLMDEHYDDDQGTENFSCKDENFEAEPIDGTNMEEEYATLVPISMKEARAALEIFTKYRRGDLMCTICKKKFNNQTLFEVHLRMHDQHTSGNFQCVLCQLFYKTEFLLKTHMTDKHIYKYICKKCPEVNFDRSSAKKHYIYTHLDLGHRKAGNLYNELRPSWLRKSGIARPQNTSKVRPGRKVVKLPEDFLMYNPVSQEEQYRLVQERKTTRNYQEATYKCELCFKGFREAVTYGKHMKKHDPAISGNLQCDMCKLHFRDARKVYKHMIITHLFRYSCQVCNFVCFNKGQAHMHYRWHKNVTYTCEFCKKEFKKASTRLTHIRIKHPSTIVCDICGHSFVSENGLYCHKKIAHSKEELESSAAKQTDPLHPHYCADCDVQFQSVTAYKTHLGSSNKHASTNLSIKPVRLSRPSGAAKKPGRPRNGSSEIVNTGVPTASHCEICNKFLTNDVQARKHYETEHPGAEFPKRYMCDVCGHTTRQYANLMVHMRTHTQEKPYGCPHCDRRFSMPSNRDRHLVVHTGEKKYQCQHCSRRFTQSSAVKLHIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRKRRKVTHHTVQEVPVPALLIQTVHLKIPYAPWDKKNRTRRKEMEGGPPVSAPPLPAPPPKLLLDAQGDYLNAYITYSDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-