Basic Information

Gene Symbol
-
Assembly
GCA_949987645.1
Location
OX465278.1:28279971-28281914[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.22 28 6.9 0.2 1 23 263 286 263 286 0.93
2 10 0.6 77 5.6 1.8 6 23 295 312 295 312 0.97
3 10 0.00097 0.12 14.3 0.3 1 23 318 341 318 341 0.96
4 10 0.0014 0.18 13.8 2.9 1 23 350 372 350 372 0.96
5 10 0.00026 0.033 16.2 0.1 3 23 382 403 381 403 0.96
6 10 2.2e-05 0.0028 19.5 0.3 3 23 411 431 410 431 0.98
7 10 0.019 2.5 10.3 0.3 1 23 438 461 438 461 0.94
8 10 0.00011 0.014 17.4 1.2 1 23 469 492 469 492 0.96
9 10 3.1e-06 0.0004 22.2 0.5 1 23 498 520 498 520 0.98
10 10 8.3e-05 0.011 17.7 2.5 1 23 526 549 526 549 0.98

Sequence Information

Coding Sequence
ATGGATTCATGTTTGTTGTGTTTAGATGTAAACAAAGACATATTGGATTGCATTAGAGTAAACTCAGTACAATGGCAGGAGCTTGATATAGTgaatataatagaaaaacacTTTTGGTCATTAAGCACCATTCAGCCAACTTCATGGATATGTTCATCATGTTGGAGGGAGGTGTACTGTTTCCATAAATTCTATTTGCAAATAGAAGAGTCCCATATTAATTTTGGCAAAATAAAAATGGAGGAAGATGAAGACGATACGaggattttttttctagaatcCGAAAAACTATCGGATCATTCCCAGCTTCCAAATTTTATCGAGCCTGAAATTCTGATAAATCAGATAAGTCGTAGTGAAAAACGTGAAGTGAGTATGCCTCTAGATGAATTGGATTTGGATGATGTGCCGCTCAAAAAGATATGCCAACAGTTAAGATTAGAAAATGCTGTAGAATGCAGGGATCCCctagaaaaatctaataagTTTGAGACGAGAAGAAATTTGAAGAAAGGTAAAGCAAAAGCAGATGTTGAAGTAAAATCAACAGAAACAACCACTACAGAAAATATGCAAGTTAAAGAAGAACCTGAGGATTCCAATCATATTGATTTGGAGCCTACAAGTGATAACAAAGATGATGGTTTGGATGTAAGCTTTCACCCATATCAAGATTTCTCCGTTGATTCAGAAAGCGAAAGAGATAAGGCTTGCGGTAAACAGAGTATAGCTCATAAAGAAAAAGATAAATTTATTGTCGAACACTTCAGGCGGTTTGGCTTTAAATTTATCTGTGATGTTTGTCAAGTTCCTTTCGAAGATTTCACCGCTATGCTGAAACATTTTACTAAGGCTCATCAGAAGCGGGGTTATGTTGTTTGTTGTACCAGAAAATTTTACAACCGTCGTTCTTTAATTGACCATCTTCACTGGCATGTAAATCCTGATCATTTTAAATGCAAGAATTGTGGTAAAGTATTGTCCGGACGCGTAAGTTTTGACAGTCACATGCTGCTTGTACATAGAGCGAATGAGGTCGTTAAACAACATTTTTGTGATGTGTGTGGTAAACCTTTTTCGAAGGCTTGTGTGcttaaaattcataaattaactcatttatcggaagaagagaaaaaaaatccttGTAGCGAGTGCGGTAAAAAATATGCCACTCCTTACGTACTTAATCTCCATAAGCAAACAGTCCATCTCAAGCGATTTGCTAAAATCTGTAATATATGTGGCAAAGCGATAAATTCAAGTGCCGAATTTAAGAGACACATGAACAAACACGAAGGTATTCTACCAAATTTTAATTGTGATGTTTGCGGCTTACGTTTGACTAGTGAACGAGGTTTAAAACTGCACAAGGAATCTCAACATCCGGTTGGAGGGAAACAAGACCATCATTGTCCCATATGTCCTAAAATATCGCCCACACTTAAAGCATTACGAAAACACATCAATACCATGCATAAAAAGGGACATGATCACAAATGCAATATTTGCCCAAAGGCATTTAAAAGGGCAGAAGTTCTTAGGGAACATATGGCTTCACATACGGGAACTCCTTTATATACGTGCTCCTGGTGCCCAAAAACGTTTAATTCAAATGGTAATATTCACGCTCATTACAAAAAAAGGCATCCTAAGGAATGGGAGGCAGCTAGACTTCAAAAGTATTCGGATAATTTCAAAGCTAATATGTTAACACATAATTCGTAG
Protein Sequence
MDSCLLCLDVNKDILDCIRVNSVQWQELDIVNIIEKHFWSLSTIQPTSWICSSCWREVYCFHKFYLQIEESHINFGKIKMEEDEDDTRIFFLESEKLSDHSQLPNFIEPEILINQISRSEKREVSMPLDELDLDDVPLKKICQQLRLENAVECRDPLEKSNKFETRRNLKKGKAKADVEVKSTETTTTENMQVKEEPEDSNHIDLEPTSDNKDDGLDVSFHPYQDFSVDSESERDKACGKQSIAHKEKDKFIVEHFRRFGFKFICDVCQVPFEDFTAMLKHFTKAHQKRGYVVCCTRKFYNRRSLIDHLHWHVNPDHFKCKNCGKVLSGRVSFDSHMLLVHRANEVVKQHFCDVCGKPFSKACVLKIHKLTHLSEEEKKNPCSECGKKYATPYVLNLHKQTVHLKRFAKICNICGKAINSSAEFKRHMNKHEGILPNFNCDVCGLRLTSERGLKLHKESQHPVGGKQDHHCPICPKISPTLKALRKHINTMHKKGHDHKCNICPKAFKRAEVLREHMASHTGTPLYTCSWCPKTFNSNGNIHAHYKKRHPKEWEAARLQKYSDNFKANMLTHNS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01397822;
90% Identity
iTF_01074770;
80% Identity
-