Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 6.3e-05 0.0022 18.4 1.9 1 23 6 28 6 28 0.98

2 7 0.26 9.4 7.0 1.0 2 23 35 57 34 57 0.91

3 7 8.1e-05 0.0029 18.1 2.1 2 23 64 85 63 85 0.97

4 7 0.00025 0.0088 16.6 0.3 2 20 92 110 92 113 0.94

5 7 0.0013 0.044 14.3 6.4 1 23 119 141 119 141 0.94

6 7 1.2e-05 0.00044 20.7 0.1 1 20 147 166 147 169 0.92

7 7 7.6e-05 0.0027 18.2 3.0 1 23 175 197 175 197 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	6.3e-05	0.0022	18.4	1.9	1	23	6	28	6	28	0.98
2	7	0.26	9.4	7.0	1.0	2	23	35	57	34	57	0.91
3	7	8.1e-05	0.0029	18.1	2.1	2	23	64	85	63	85	0.97
4	7	0.00025	0.0088	16.6	0.3	2	20	92	110	92	113	0.94
5	7	0.0013	0.044	14.3	6.4	1	23	119	141	119	141	0.94
6	7	1.2e-05	0.00044	20.7	0.1	1	20	147	166	147	169	0.92
7	7	7.6e-05	0.0027	18.2	3.0	1	23	175	197	175	197	0.98

Coding Sequence: ATGAAAGCATTGCCATATCAATGTACTATATGTAATCGACGGTTTTTTTATGAGGAACGTTTAAATAGTCATTTACGAGAACACGATGGAAAAAGAGGTGTGACTTGTGAATTGTGTTGTAACGAATATACAACATTTTCCGGTTTGCAGAAACATATTGAGCTTATGCATAAAGACAGTTGGACCATACGTTGCGTACATTGTGATAAACTGTTCACCAGTAATAATGCTTTATCTACCCACATGACTAGGCATATCGGTCGATCCAAGGCAGTTTGTGAACATTGTGGGAAATCATTTTTCGATATAGCTGCATTAAAGACTCACTTGCCTGCCCATCAAACGGAtacgccattcgaatgcgatgaatgtgggaagaaatttaaaactcaaagacatcgtcatgcgcattcatttcgacataagggtataagaaattttgcatgtccatcgtgtgataagACGTTTGTAAATCGTCCGGAATTGCGTCAACATATGCCCGTACATACTGGGGATAAAAACTTTAATTGTAATGTGTGTCAAAAATTATTTCGATATAAAAGTCAGAAGATATCACATATGCGATCACATACGG
Protein Sequence: MKALPYQCTICNRRFFYEERLNSHLREHDGKRGVTCELCCNEYTTFSGLQKHIELMHKDSWTIRCVHCDKLFTSNNALSTHMTRHIGRSKAVCEHCGKSFFDIAALKTHLPAHQTDTPFECDECGKKFKTQRHRHAHSFRHKGIRNFACPSCDKTFVNRPELRQHMPVHTGDKNFNCNVCQKLFRYKSQKISHMRSHT

Sequence clustering based on sequence similarity using MMseqs2