Basic Information

Gene Symbol
grau
Assembly
GCA_027564815.1
Location
JANTOP010009095.1:3540-5417[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 2.5 89 3.9 1.2 1 15 52 66 52 68 0.82
2 11 0.0056 0.2 12.3 1.6 2 23 217 239 216 239 0.94
3 11 0.11 3.8 8.3 0.3 6 23 248 265 248 265 0.99
4 11 5e-06 0.00018 21.9 0.6 1 23 271 293 271 293 0.98
5 11 1.1e-05 0.0004 20.8 1.0 1 20 300 319 300 323 0.91
6 11 0.0039 0.14 12.8 1.7 1 23 332 355 332 355 0.86
7 11 0.0049 0.17 12.5 0.2 2 23 362 384 361 384 0.96
8 11 0.47 16 6.3 0.4 2 23 393 414 392 414 0.94
9 11 0.00013 0.0044 17.5 0.2 2 23 420 442 420 442 0.95
10 11 3.6e-06 0.00013 22.3 1.2 1 23 447 469 447 469 0.98
11 11 0.016 0.55 10.9 2.0 1 23 475 498 475 498 0.98

Sequence Information

Coding Sequence
ATGCCACCCAAAACCATTAAATGCCGACTATGCGATACGTCCATAGCCAAAGGAATCGAAATTTTTGGAAAGCGAGGGAATAAATTATCTTTAGTAGCTGTATTGAGTCAACACTTCTCTATAAAGTTCACCAACAATGAAATTTTCTCAAAATTTGTCTGCAAGAAATGTTGGAAAACCACCGAAGATTTCCATAAACTGTATTGCACCGTAAAACGGATCGAATACGAGTATTTGGAACGATTAAAACCAATAAAAACTGATAAGAATACAATTCAAGATGATGAAATCAAACAAGAAAGTAACATTAAGGATTCGTCAGATTCAGAATCGGGAGTAAATAATTTAGAGATCAATTCGGGACAGTCAACGGAAACAATCGTTAAGGTTGAAGTACTTGTTGAGACTCCATTAGATGATAATGATTCCGACAGTTGTAGAAACCAAGAGGATGACTTACCCGATGAGGATGAAAATAACGATGTGGATAATATCGAGAAACCAGAACGTAAGAAACGTAAGCGATCCAACCTGTCAAGAAAAATCCGTACCCAACCGAAACGAAAAATTGTATCTACGAAACATTTAACCGATCATCAACAAAACACGATCAACCTAGAGGAGAAAATTGACAATGAATTGGGAATGCAATGTGAAATTTGTAATGAAAAAACGAAAACATTTTTCGAATTGAAAAAACATTTCCGTGACGAGCACAATTTGAACGGATACCTCAAGTGTTGCGGAAAAAAATTCTTTCGACGTGGAATGGTGTACAACCACATTCTAAGCCATAACGATCCCGATCGATATAAATGTGAACAATGTGGAAAGGTTTATGTTGATAAGGAACGATTACGGAAGCATGTTATCCGACATGATCCATCTTCAAGAAAATACCAATGCAGCAATTGCCCAAAACGGTTTACAACACCATCGATGTTGAATACACATTTTTTTGCCGTACACAAACCATCCGACTCGCCGAAAAGTTTTATTTGCGATATATGCAATAAATGTTTCTCATCGAAGGGTTCCGTTTACTTTCATATCCTTTCCGTTCACACCCAAAAATATTCACTAATTTGTGATATTTGTGCGAAAGTATATCCCAGCCAAAAATTATTGGATTATCATTATAAAACAACGCACATGAAGATTACGTTACCGAAAATCCAGTGTACGATTTGTGGATCATGGCTCGCACATCTTACCGGTTTAAAGAAACATATGTACTTGCATACGGCCAAACAGGAAACGTGTAACATTTGTGGAAAGGTAACGCCAAATAAGAATGCCCTTCGAGGCCATATTCGTTTTGTGCATAACACCGAACTATATAACTGTAACATTTGTGACAAACAGTTTAAATCACGAAAGACATTACAGgagcatattgggacgcatactggtaattccctatacaaatgtaaatattgtctgatggattttaattctggtgcgaatatgtacaaacatagaaaaaagattcatccaattgaatGGCAATTAGATCGAGATAAAGTGTTGAATGGTTTTAAGAGCAACGAGAATAATGGTCAATCAACAGAATTAAATTAA
Protein Sequence
MPPKTIKCRLCDTSIAKGIEIFGKRGNKLSLVAVLSQHFSIKFTNNEIFSKFVCKKCWKTTEDFHKLYCTVKRIEYEYLERLKPIKTDKNTIQDDEIKQESNIKDSSDSESGVNNLEINSGQSTETIVKVEVLVETPLDDNDSDSCRNQEDDLPDEDENNDVDNIEKPERKKRKRSNLSRKIRTQPKRKIVSTKHLTDHQQNTINLEEKIDNELGMQCEICNEKTKTFFELKKHFRDEHNLNGYLKCCGKKFFRRGMVYNHILSHNDPDRYKCEQCGKVYVDKERLRKHVIRHDPSSRKYQCSNCPKRFTTPSMLNTHFFAVHKPSDSPKSFICDICNKCFSSKGSVYFHILSVHTQKYSLICDICAKVYPSQKLLDYHYKTTHMKITLPKIQCTICGSWLAHLTGLKKHMYLHTAKQETCNICGKVTPNKNALRGHIRFVHNTELYNCNICDKQFKSRKTLQEHIGTHTGNSLYKCKYCLMDFNSGANMYKHRKKIHPIEWQLDRDKVLNGFKSNENNGQSTELN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-