Basic Information

Gene Symbol
ZNF438
Assembly
GCA_027564815.1
Location
JANTOP010038282.1:6574-10681[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.021 0.74 10.5 0.2 1 21 362 382 362 383 0.94
2 13 2 71 4.3 1.6 2 23 459 480 458 480 0.91
3 13 0.0026 0.091 13.4 1.6 2 23 486 508 486 508 0.95
4 13 0.00017 0.0062 17.0 0.2 2 23 513 535 512 535 0.94
5 13 0.0017 0.061 13.9 6.5 1 23 541 563 541 563 0.98
6 13 0.0042 0.15 12.7 0.7 1 21 569 589 569 590 0.94
7 13 3.4e-05 0.0012 19.3 0.1 1 23 601 623 601 623 0.98
8 13 2.1e-05 0.00074 19.9 1.2 1 23 629 652 629 652 0.96
9 13 0.00023 0.008 16.7 4.4 1 20 674 693 674 696 0.95
10 13 1.3e-06 4.6e-05 23.7 1.4 1 23 704 727 704 727 0.93
11 13 0.0021 0.074 13.6 0.4 2 23 734 756 733 756 0.95
12 13 0.00078 0.028 15.0 0.7 1 23 762 784 762 784 0.98
13 13 0.00013 0.0045 17.5 1.5 1 21 790 810 790 811 0.95

Sequence Information

Coding Sequence
ATGCCTGGACTTAGAATATTTGCTGTACCAAAAATAAATAAAGATCTCCGTTCTCTTTGGCTTTTCAAATGTGGCCTCACTGAGAGCGATTTAAATTTGTTCGTTTGCGACAGACATTTTCAGAAAAGTCTTATTAGTAAGAGAGGTTTAAAACATGGTGCAGTACCATCATTATCGTTGCCAGCCTGTGCTCCAACTCAAAATGTACCACTTTCATCTATATTATCTGAAAATGATCCCGATGAATTTGCTGATGAATTATCTACCCATTCAGAAATCATTAAAGGAAATCAGCAGCCAGGGCAGATTATGACGAAGGATAAGGAAAACGATCCTGATATTCCTAAAATAAATGAAGCTAAAGTGAGGAGACATAGAGATTCGAATAGTAACGATGAAAAATCGATTAAAATCAAGGTTACGACTATGATATCGAAACGAATTATGGAATTGAATAAGCTTCTGAAGAATATTCTTAGAAACAATGTTACTGTTGAAGAACAACAGCTTTTTTTACAGTATAATGAAAGACCGGACTATCCATTCTTACAATGGTTGGAGGCCACATCAACTTCGACTACCGATTTAGAGCAGACTTGCCGCGTTTGTGTTCGTTTGATGACGACACATGAGAAACGGGTCAGTTTGTTTTGTGACCAGACCGGTAATAATTTCAAAACCGATTTTAGGGAATTGAATAGCATGAATTTGAAGATCTATCGAGATGATGGACTTCCACAGAATATTTGTGGTCCTTGTGCCACCCGATTGGAGCAATTGAAGGAATTTCGTTTACAGGCTGTCAGAGCTCAATACATTTTACAGGATTATTTCGATCGAATTGTTAAGGCAAATGATTTGGATGATACGTTGGACGCAAATCAGCATATAGAAGATGTTGATATTGAATTGTTTAAAGAGGAGCCACCAATTGATATTTTCGATTCTTCTGAACTGGATCTTCCTTTAGTGAATACTCGAATCAATAAATTTTTATATCAAAGTGATCAAGATAATGAATCGAATGATAAAATGATTGATATCAGTGAATTCGAAGTTGTTAATTCCGTTAATGATTTGAAATTTAAATGTAACGATTGCGAAGCAACGTTTAAGGAATACATAGAGCTGTACGAACATAGACAAATATGTAAGAAACAAATATCAGAACCGGCATCACAACCAAACATATCCGCTCCAGTCGATCTTGTTGAGGAACCGCGAGATGATAATGATTCATGCTCGAATGAAATTAATTCAATTCCGTCGACTGAATCAATTGGTGATGCATCAAAAACGAAACGAGTTGGAGGATGTAGAGGAAAGAGAAAAATTGGAAATGATACTCTGATGAGTAACTATAGATTCACAAAACGATGTGGAAGATGCAATAGGATATTTCGGTCACATGCCATCCGAAATGAACACATGTTAGTTCATAATAAAGGTAATCCTCAATGTAAGAAATGCGATTGTTATTTCGAAGTAAAAAGCGATTTAACCGCGCATTATAACGAAGTACATCCAAGTCCGTTAATTTGTACGACATGCAACCGTACTTTCGGAAGTCCGAAACAACTACGTGCGCACTTAGCAATATCGCATAATGCACCTCGAAAGCATAAATGTCAGTATTGTGACAAAAGATTCCTAAAAGCATCCCATTTAAAAAATCATGAGAATACGCATACGGGTGCCCGACCATATTCATGTACAGCATGCGGAAAAACGTTTCGAAATGATGGTACATTTTCAACGCATCGTATGAGGTGTGACCAATTACATACACGGTCTAATTCATACAAAtgcgaagtatgtggtaaatcatttatttcggaagcagtgctcattcagcataatcgttctcacaccggtgagaaaccgttcatatgtgatttatgtgacagacgatttgttcacatgtataatttgaaacaacacatgataagcgctcatatcgAAATTAACAAAACGAAAGGAGACGGTTGTGGTGAGAGTGATGGTATAGCCACCAGCGATTATAAATGTAATATATGTAATAAACGATTTCGATTTCAACCATCGCTAACCAAACATTTAGAATGCCATGTGGATGAGGAGGAACGTAAATACGTGTGTCAGATATGCAACCAGACTTTTAAACGTTCTGACCATTTACGTAAACATATCGATGGTGTACATTTACGGTTGAAAAAGATCAAGTGTGGTATGTGCGAGAAGACATTCCTTCATCGGAGTACGTTAAACGTGCATATAGCCGTAGCTCATCAGACGGAGTCCAAAtatgaatgttggaattgtggcaagaaattgcttagtctaagaacattacgccgacatatgagaattcatactggcgagaaaccgtatcgatgtgatatgtgtggtgcatgtttcacatattatatagaactaagaaGACATATGACGAAAAAGGAGGAGCGTGTACGGCATAGATGA
Protein Sequence
MPGLRIFAVPKINKDLRSLWLFKCGLTESDLNLFVCDRHFQKSLISKRGLKHGAVPSLSLPACAPTQNVPLSSILSENDPDEFADELSTHSEIIKGNQQPGQIMTKDKENDPDIPKINEAKVRRHRDSNSNDEKSIKIKVTTMISKRIMELNKLLKNILRNNVTVEEQQLFLQYNERPDYPFLQWLEATSTSTTDLEQTCRVCVRLMTTHEKRVSLFCDQTGNNFKTDFRELNSMNLKIYRDDGLPQNICGPCATRLEQLKEFRLQAVRAQYILQDYFDRIVKANDLDDTLDANQHIEDVDIELFKEEPPIDIFDSSELDLPLVNTRINKFLYQSDQDNESNDKMIDISEFEVVNSVNDLKFKCNDCEATFKEYIELYEHRQICKKQISEPASQPNISAPVDLVEEPRDDNDSCSNEINSIPSTESIGDASKTKRVGGCRGKRKIGNDTLMSNYRFTKRCGRCNRIFRSHAIRNEHMLVHNKGNPQCKKCDCYFEVKSDLTAHYNEVHPSPLICTTCNRTFGSPKQLRAHLAISHNAPRKHKCQYCDKRFLKASHLKNHENTHTGARPYSCTACGKTFRNDGTFSTHRMRCDQLHTRSNSYKCEVCGKSFISEAVLIQHNRSHTGEKPFICDLCDRRFVHMYNLKQHMISAHIEINKTKGDGCGESDGIATSDYKCNICNKRFRFQPSLTKHLECHVDEEERKYVCQICNQTFKRSDHLRKHIDGVHLRLKKIKCGMCEKTFLHRSTLNVHIAVAHQTESKYECWNCGKKLLSLRTLRRHMRIHTGEKPYRCDMCGACFTYYIELRRHMTKKEERVRHR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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