Basic Information

Gene Symbol
su(Hw)
Assembly
GCA_949127995.1
Location
OX421843.1:53620261-53623907[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00036 0.026 15.4 1.9 1 20 133 152 133 153 0.95
2 12 9.2e-06 0.00065 20.4 0.3 3 23 205 226 203 226 0.93
3 12 1.3 94 4.2 0.2 1 23 232 254 232 254 0.79
4 12 8.4e-07 5.9e-05 23.7 2.5 1 21 261 281 261 282 0.95
5 12 8.1e-06 0.00057 20.6 1.1 3 23 295 315 293 315 0.96
6 12 3.5e-05 0.0025 18.6 3.0 1 23 326 348 326 348 0.98
7 12 1.9e-05 0.0013 19.4 0.8 1 23 354 376 354 376 0.97
8 12 7.7e-06 0.00055 20.7 0.7 1 23 382 404 382 404 0.99
9 12 4.9e-06 0.00035 21.3 1.1 1 23 410 432 410 432 0.98
10 12 1.9e-06 0.00014 22.6 1.2 1 23 436 458 436 458 0.98
11 12 0.00065 0.046 14.6 5.2 1 23 474 497 474 497 0.96
12 12 0.063 4.5 8.4 0.4 3 23 511 532 509 532 0.94

Sequence Information

Coding Sequence
ATGAATATTAAACAAGAGGGCAGCAGTGGCCGGCCCCTTGGCAATGCCATCAAGATCCTAAACGATGAGCAAATTCCACCGCTAATGTTGCCAGTTATGACGTCTGTGCCGTTGGCACCCGTTAAGCAAATCAGCTTGTCTATAGCAAAAACGAAACCATCGCCCACCAagagcagcaacaaacaaatggATCATTATGTGCTGCAAACGATTAAGGGCGAAGCAAATGAGGAGGGCGTCATTGACGAAACAATTGATTTCGTGCTCACAGACAAAGATGCCGAGGCGGATCGCAATGGTGGACTTAGCGGTCCAAGCGGCGAAATCACTGAGGAACTGCACTTGAGCGGAGACGAGGAGGAAGATGGTGACGAAAAGACAGAAGAGATTGTGGAACACGTCTGCGGCAAGTGCTACAAGTCGTTTAGGCGCTTCAGTggtttaaagaaacatttagATTTTTGTCGTTTTGACAGCGGCTATCATTTGCGCAAAGCGGAGATGTTGAAGAACCTTGAGAAAATTGAGAAAGATGCCGTGATTATGGAGAACAAggatatttgcttttgttgtggcGAAAGTTACGATACATATCAtCTGGGGCACATTAACTGTCCCGATTGTCCGAAATCCTTTAAATCTCAAATGAGCTACGAACGCCACATTTTCATTACCCACTCAGAGTTCAACGATTATCCGTGCACGATTTGCAATGCGAAATTACGAAGCGAAAATTTAAAGACACTCCACGTCGATCAGCATCAGAATCGTGGTAAGCCGTTTGCTTGCAAAATATGCGGTAAAGATTTTACGCGCTCGTACCACCTCAAACGTCATCAAAAGTATTCGTCATGTTCGGCGAATGACATCGACTCGATGAATTGCAAAGTTTGCAATAAGGTCTTCTTTCGTTTGGACAATTTGCGGGCTCATCTTAAACAGCATTTAGGCACTCATGTCGCCAAAAAGCCAGAGTATATGTGTCCCATTTGCAAAAACTGTTTCTATAGTTTATCTACGTTGAAcatTCACACACGTACTCACACTGGGGAACGTCCTTTTGACTGCGACTTATGCGACAAGAAATTTCCGTCTTTGGTGGCACTAAAGAAGCATCGTCGCTATCATACCGGCGAGAAGCCCTACACCTGCTCGGTCTGCAATCAATCGTTTGCCGTCAAAGAGGTGCTCAATCGTCACATGAAGCGGCACACGGGCGAGCGTCCGCATGTCTGCAGCGAATGCGGAAAAAGCTTTATTCAAGGCACACAGCTCCGCAGTCATGCTCGGACCCATCTTAAACCCTTCGAATGCTCAGATTGCgacgaaaagtttaaaacagaaaaacaGTTGGAAAAGCATGCTAAGACACACATTCAAACATCAAAACGTAAGCGCAAAGCTGCGGTGGCGCACGAGCACAGTTGTGACATTTGCAAGGCTACTTTTAAACGAGAGACTACTCTTATGCATCACATGAAACAGAAACATGATAAGGttaatgcAAAGTCTGCCGCCGGACGCACATTTTGTGaaatatgcgaaaaaaatttcgaCACGGTTAAAAGTCTCGAATTTCATATACTCAAAGTGCACGAAGTCGATCCTGAAGAGTTTATCAACTCGAAAGGCGTATCGGACACGGATCTAATGCCACCgcctaaaatttataaaattgaatcaaaCAGTGGCTCAACtcaaattgaatatatttcgAACAGCGATAGCGAACTCTTGACGAAAACTAATGCCACAAAAGCATCAAACGTTGATGGAAGCGCTGATTCTGCTGACAGTGGTCTGCTAGTGCAAGAGTTTATAATTGACGAAATGCCATCGACGAGCACCAagcaaacaataattttgcaGAATGAGTCTTTCACTGTTATACCATTGGATTCGGAGCCAGACGGTATTATCAAAACATTGACTACGAATACAATGCCTAAGCAAGTGGCATCGCCACCAACCGCCAACGCTGCCGAATTCAAGAAAAAGGGAATGCGCAAATCGTTGGCCGAAAGTTTAGCTGCCGCCATTGCGGACGACGATGAAGATGACGACGGACTGACGTTGGAAACCGAAGAAGATTTGAAATTGAAGGATAACGTTGGAAAGCTATTGGATATGCTTGTTGATAATGCCACGCTAAAGAAATTTGGCTGGCCGCAAACTACCGAGGAAAATgttctctgcaaAGTTATCGAAAACTGTGGTCACGACTTGACAAAGGATACGGAAAATTACAACGATTGCGATTACGCTACACGCATGCGGGAATATGTGAAACTGCTCTTCACAGTTGTCATACACAACGACTCGATAAAAGAGCTCCTCAACAATTATCCGATCGATGAAGTTATCGAATACGTTTTAGGCAACGATGACGAGGACGATGAGCTAGATGACAATAATGAACAAGAGAATGCTCCTACTGTCGAACTGAAAACCTAG
Protein Sequence
MNIKQEGSSGRPLGNAIKILNDEQIPPLMLPVMTSVPLAPVKQISLSIAKTKPSPTKSSNKQMDHYVLQTIKGEANEEGVIDETIDFVLTDKDAEADRNGGLSGPSGEITEELHLSGDEEEDGDEKTEEIVEHVCGKCYKSFRRFSGLKKHLDFCRFDSGYHLRKAEMLKNLEKIEKDAVIMENKDICFCCGESYDTYHLGHINCPDCPKSFKSQMSYERHIFITHSEFNDYPCTICNAKLRSENLKTLHVDQHQNRGKPFACKICGKDFTRSYHLKRHQKYSSCSANDIDSMNCKVCNKVFFRLDNLRAHLKQHLGTHVAKKPEYMCPICKNCFYSLSTLNIHTRTHTGERPFDCDLCDKKFPSLVALKKHRRYHTGEKPYTCSVCNQSFAVKEVLNRHMKRHTGERPHVCSECGKSFIQGTQLRSHARTHLKPFECSDCDEKFKTEKQLEKHAKTHIQTSKRKRKAAVAHEHSCDICKATFKRETTLMHHMKQKHDKVNAKSAAGRTFCEICEKNFDTVKSLEFHILKVHEVDPEEFINSKGVSDTDLMPPPKIYKIESNSGSTQIEYISNSDSELLTKTNATKASNVDGSADSADSGLLVQEFIIDEMPSTSTKQTIILQNESFTVIPLDSEPDGIIKTLTTNTMPKQVASPPTANAAEFKKKGMRKSLAESLAAAIADDDEDDDGLTLETEEDLKLKDNVGKLLDMLVDNATLKKFGWPQTTEENVLCKVIENCGHDLTKDTENYNDCDYATRMREYVKLLFTVVIHNDSIKELLNNYPIDEVIEYVLGNDDEDDELDDNNEQENAPTVELKT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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