Basic Information

Gene Symbol
ZFHX3
Assembly
GCA_035578905.1
Location
JAQJVL010000177.1:1088449-1096902[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 1.9 7.7e+02 3.8 0.3 1 23 30 53 30 53 0.83
2 15 0.051 20 8.8 0.1 1 23 69 92 69 92 0.92
3 15 0.0053 2.1 11.9 2.4 2 22 176 196 175 199 0.91
4 15 0.78 3.1e+02 5.1 1.7 3 23 213 236 211 236 0.88
5 15 0.021 8.4 10.0 1.7 1 23 256 278 256 278 0.97
6 15 0.015 5.8 10.5 1.5 2 23 285 307 284 307 0.96
7 15 0.00084 0.33 14.4 3.9 1 23 415 439 415 439 0.92
8 15 0.0099 3.9 11.0 0.6 1 22 459 480 459 483 0.89
9 15 0.0013 0.53 13.8 0.2 1 23 545 569 545 569 0.93
10 15 0.88 3.5e+02 4.9 0.1 2 21 684 703 683 704 0.93
11 15 0.3 1.2e+02 6.4 2.0 2 19 855 872 854 877 0.91
12 15 0.00021 0.084 16.3 2.5 1 23 1542 1564 1542 1564 0.99
13 15 0.0015 0.58 13.6 0.2 1 23 1654 1676 1654 1676 0.98
14 15 0.012 4.6 10.8 0.4 2 23 1849 1871 1848 1871 0.96
15 15 0.6 2.4e+02 5.4 3.5 2 23 2146 2169 2146 2169 0.89

Sequence Information

Coding Sequence
ATGAAAGTCTCCACGCCTACTTCCCAGAGTGACCAGCACTCTCAAGTCCAAATTGACTCCACCGAAGACAAGGCCAGTGGTGACACACATATATGTCCTTATTGCAACTACTCCAGCAACAGTGAGATGAGAATCCAAGCGCACGTGTTGGCCCAGCACTCCCAGAACGAGAGGTCTCCATCGGCCTCTTCTCCGGTGAGAGAATTCCTGTGCCCTCTCTGCCAGGATGGGTTCAGAGATCGACCCCAGCTAGAGAAACATGTAATGCAGATCCATAGTGTGAACTCTGAGGGACTCCAAAGGCTGCTTATGTTAGTCGACCAGTCTCACTGGCTCAACAATTCTTCTAGACAGAGCCAGCAGCAACAGACTCCTCCAGGACATCACCACAGTCCTGCGTCAGTGGCTTCCTCCTCCGGAAGCAAGGATCAGGAGAAACCGAACACTTCTGAAAGCTCAAGAGAAGAAGACAAAGAAGAAGCTCAAAACCTCTCATCAACTGACGATCAAGCTGaggatgaaaataaatgtcagacCTGCCAAAAGACCTTCAGAAACATTGACGAGCTTTGTTTACATCAAAATGAGAGTGGGCATTTGGAGTTAAAGCAGACACCGAGTGGGCCAGGATATTTGTGCTGGAAAAAAGGCTGCAACCAGTATTTCCAAACCGCGCATAGTCTTCAAATGCATTTCCGGGAGATTCATGCACGCGGAGGAAATGCTACTCCAGCAGTTGCTGTATCTGAAAAACACGTATACAAGTACAGATGTAGTCAGTGCAGTCTCGCTTTTAAGACCATGGAAAAACTTCAATTACACTCGCAGTATCATCTTATCAGAGATGCCACTAAGTGCGTTTTCTGTGGGAGGAGTTTTAGATCGATTTTAGCCTTGCACAAACATGTAGAGACGTCTCATTCAGAGTTATCTGATGAAGAGTTGATGGCTTACAAACAGAGCCTGATGAACAATCCTCTTTTGTTAGCTGGTATTAGTGGCCAGATTCTAGATCCTTCCACGAATGAACTGCTGCGAAAGGAGAGTTTGAAAATGGAATGTGAAGAAGGCATGGAATTAGAGGAAAGCCCAGGAAAAGATAATCCTGATGATTCTGTGAATCAAACAGGAGACGGGGAAAATAGTGATGATTCAATTGTGTACAAAGAACAACAGTTTTTAGAAGATTACTTAAATAGTCAAGCAATTGCTGAAGATAGCTACAACGATCCTAATAGAAAGTATAAATGTCACCGTTGTAAGGTGGCATTTACACGTCAAAGCTATTTAACTAGCCACAACAAAACATTGTTGCATAGGAAGGGTGAGAAACTGAGCTACCCGATGGAAAAATATTTAGATCCTAATAGGCCCTACAAATGTGATGTTTGTAAAGAATCATTCACtcaaaagaatatattattaGTTCATTACAACTCAGTAAGTCACTTGCACAAATTAAAGAGAGCTATGCAAGAACAACagcaacaaaacaataataataacccAGCAGTTTCTCCACAAACCGCAGCTTCGGTTGCAGCTGCAGCTTTAGCAGCTACATTAGGGGTTTCCTCAAATCAGCTAACTCCTAAGACCCCTACAGCTATAGATGAAGACGACAAAAAACCTTATAAATGCAACATCTGTAAAGTCGCTTACAGCCAAGGGTCTACATTGGATATCCATATGAGATCGGTACTGCATCAGACAAGAGCATCAAAGCTGCAAGACCTTGCCATGACTGGTCAAATTGATCTCAGTAAACCACTGATAGAACAGCCAGAGCCTCAAAAGGCTCAAGATCAGCATAAAAAACTAATTCAGGATATTTTAGGATCATCACCCAAACATACTCTCCTAACATCTCCTCCGTCTTCGGGGAGTAATGGGTCCCAAGTGCCTGGATCATCACCAGGATCTGGTAACTTAGTTCCTTCAAGTATTTCTTCAACACCGAATTTGACATCAGTTCCTACTAGTATAGCTAACAATTCTTCGAATTCGCCTTCATCTGTGATACCGTCCCCGACCCAACAAGGCATGGTCTCGTGCCAAAGGTGCAGTGCACTATTTGGAAGCCAAGAACAATTGACTACTCATCAACAGCTCTATTGTATGTTTGGAAGCCCGATGACAATGTTCCCCCCACTGCCGACTCCTCCTTCGTCAGCATCAAACACTCTGGTTCAGTCGTTATCTTCTCCTTCCAATAAGACTCCTCCTCCTGGACCCATGACACCACTCCCTGAAGACACTTTCCCCAGAGTGTCGATTCCGTCAAAGAAGTCATCTCAGATGTACAAACATCTGTTGGAAAGCTTCGGTTTTGACTTAGTAATGCAATTCAACGAAAACCACCAAAGAAGACAAAGAAAAGAACGAGAGGAGAATGAAAAGCTGATTGCTGAAATATCTTCGACGACGCCAAGCGTGGAGGAACAGCCTATTGAGACTCTAGTAGTATCAGAACAGCCGGAAGCACCACCTCCGGAGCCAGAAGTAGAGGTAAAAGTTGAAGAGGAAACGCCCACCGTAGATCTACCAGAAGTGGCCAAGTCAACCTGCCAACATTGCAACAAAGAGTTCTCAAGTGTATGGGTGTTGAAAGCGCATTGTGAAGAGGTACATCGTGATCTAGTGCCCCTCGACTTCTTAGAGAAATATGCTCAGCAATTTAAATGTGAATACGAGAAGAAATCCGTCCCTACTTCAAGTACGTCGGCGACAAACACGACAGTAACTTCCACCACGAGCTCAGGCAGTGATGTGACTCCGGAAAAAGATGAAGATAATAAAGAAGCGATTCACGCCAAGATTGGCCTTTCACAAACTCAGTCAACGCCCCCTGATATGACGACTGCTCCTAGCACGCCGACTGCTGCATCCACGCCGGCCTCCAGCACGGACTCTCTTCCTGCTACCATTAGCAGTACAATCGCCGCAGTGGCTGCTGGTATGGGGGGAGCTTCTAACCCTAACGCCAACTTGTCTATGTCACTGGCCCAGCAGATGAGTGAAATGCAAGCTGCTCTCAATGTCATGGCTGCCTCTCAACTCCAACAACAGCTTCAACAGTTTAGCCCTGTGATGATGGGAATGGCCGGCCTAGGAATGGGATTGCCATTGGGCCTAAACATGCCTGCTTTGGCCGCCATGAACCTCCAACCCCCTTTAGTACCGATGATGATGCCTCCGCCACCCTTCGACCCACTCGGAGGACTTGGTCAGGGATTTAATCCTCAAGGAAGTGGAATCGACCCAGCTACACTCCTCGCTAAGCAGCAACAACATCTTCTGCAGCAACAACAGCAAGTTGTAAACGCATCACAGCAGAAACGTGCCCGCACTCGCATTACTGACGACCAACTTAAAATTCTGCGAGCTCATTTTGATATTAACAACTCACCCTCAGAAGACCAGATCCATGAAATGGCCGGCCAAAGTGGGCTTCCACCTAAAGTGATCAAGCACTGGTTCCGAAATACTCTCTTTAAGGAACGTCAGCGGAACAAGGATTCCCCTTACAATTTCAACAACCCGCCATCGACTACTCTGAATCTCGAAGAGTACGAGAAGACGGGGGAAGCTAAAGTGATGCCGCTTAATAGCAGCGGGAGCAGTACTAGCACGGAAGACCCTTCAACTCCTGCTAAGGATGCTGAGAAAGCACCTGCTGTAAAGTCTGCCCCGCCGCCCCCACCACCACCTCCACCACCCCCGGCCCCCCAGCAACTGCCGGCATCACCAATGCAACCCCCTCATAAAAGTGGGCCACAACAATCACCTATGCAACAACAGCAAAAACAGCAATCTGCAATGCACCATCAGTCTTCATTTCATCAACAGACTCAGTCATTTCCTCACCCACCTGACGCAATAAAGAAAGAACCTAGAGATCCAATCAGCCAACAACAACTTGATGAACAAAAATTTACCACCATGCTGATGGAAGCTGAACAGAGGATGAAGAGGGAGATGGTTGATGAAAAACCGAATATATACCCGGGCCAATCACTATCACCCCCCAGTCCTCATATGAACGATAGAATGAACATCATTCCAGCGAGAAATAACTCTCCAGAAAATTTAACTCTTACTTCTATAATATCTTCTCAACTTGGACCAGAATCCATGTCGATGAACTCTCCAACTCAACAGATGCAAGTTTCCCATTCCAACATGCTACCACCCAAATTGACTCCCCCAAACTTTACTTCCCCAAGCCACATGGGATCCAGTGGTATGCCGTTGACGCCAACGTCAAGAAGTATGAGTCCCGGAAGATCGGGTTCAGCCGATTGCTTCAGTCATGCTATGCTTGGTGGTCCCAACGGAAACAACTCAGCGGGATCCAGTGGAAAGAGAGCTAACAGAACGAGATTTACAGATTACCAAATTAAAGTTTTGCAGGAGTTCTTCGAGAACAATGCCTACCCAAAAGATGATGATCTTGAATATCTTTCTAAACTTCTAAATTTAAGCCCCAGAGTGATTGTAGTCTGGTTTCAAAATGCTAGACAGAAGGCCAGGAAAGTTTATGAAAATCAACCACCTGTAGATCCTACTCCTGGATTAGACGATGCTGGCGCAGGAAGATTTCAGAGGACACCAGGATTGAACTATCAATGTAAGAAATGTCTGCTGGTTTTCCAAAGATACTATGAACTGATTAGACATCAGAAGACCCACTGTTTTAAAGAAGAAGATGCTAAAAGATCCGCTCAAGCCCAGGCAGCGGCCGCTCAGATTGCAGCTGTACTATCATCTGAAGACTCAAACTCAAGCACAATTGTAGAGCAGAATCAGCAGAACCAACTGGCAAATTTAGTAGGAATTAACACTTGCAGCAACCCCTCCACACCAGCTGCTCCAATTACGCCAACCCCTTCGCAGTCAGTGTACCCTCCGTCTCCTGTTCCACCTAGTACGCCCACTCCCGACACCAAAGATAGTTCCTTCCAATGTGATAATTGCAATTTAGTTTTCCCTAGATTTGATCTCTGGAGAGAACACCAACTTGTTCATATAATGAACCCTAACCTGTTTCCCTCATATCCTCCAGATAGTCCCTTTGGAATACTACAGCAACATGCTCAGATGCAACAACAACAGCATCAACAACAACAGCAGCAGCAACAGCATCAACAACAAAACACCCAGCAGCAACAACAGCACCACATGAATAATTTAGTGGCAGACCTATCAATGAATCCAAACTCTAACCAACATCCTTTGATCTCAATGCTTACTTCTAATAAGCGAAAGTTTGATGAATTGGAAGATATGAATGAAAGGCCTCAAACTGGTGGAGCAGACAATGAACAGCCAAAGGATAAACGATTACGTACAACTATTCTCCCGGAGCAATTGGACTATTTGtatcaaaaatatcaaattgaaAGTAATCCTTCTAGGAAAATGTTGGAAAATATCGCAAGAGAAGTTGGCCTGAAGAAAAGAGTTGTTCAAGTATGGTTCCAGAATACAAGAGCTCGAGAACGTAAAGGTCAATTCAGGGCCCATTCGCAAGTCATCAACAAACGATGCCCATTTTGTCCAGCGTTATTCAAGGTGAAATCTGCTTTAGAAAGTCATCTCACAACAAAGCATGCAGACCAATGCAGTAGAGGAGAAATAAATATTGACGCTTTACCCGACGAAGAGTTGAGTGTAGAGTCATCGCATTCATTCCCATCTTCACAAATGGGCGATTCAGGAGCTAAAATGCAGAACTTCAGTTCAAGTCAACTCAATCAGACTATGATCCCTCCTATGTTCCCTCCTTTTCATGGCAATATGGACGattctttgaaaaaatattacgAAGAATCTATGAAAAGGTATATCAGTGAACTTCAAGCTCAACACGTCACACAAAATGGTGCCGTGACTAAAGAAGGCTTACCGTCAGACCTCAGAGTAAAAAGCGAGGGAAACGGACGAGCTGGAGAGAGTACAGGAGACTGCCCTTTGGATCTGAGCAAGCCCGTAGACTTGAGCAGACCAATCAAAATGAGTTTAGACCACGATATCCGAGCTATGATGGGAGACCCAGGTCCTTTGACGGATTTGAGTGAAAGAAGTTTTTGTGATGATGACAGCATGTCAGAGTGTACAGACAATATGGAAGGAGATGAGAGTAACCCTACCTCCCCTGCGTCCAGTACTCAAAGTAGAAATCCAGGACAAGGGGGAAATAAGAGGTACAGAACACAAATGAGTAGCTTACAAGTAAAATGTATGAAATCCCTTTTTAACGACTATAAAACCCCAACAATGGCTGAGTGTGAAATGTTGGGCAGAGAAATCGGATTGCCAAAGAGAGTCATTCAAGTGTGGTTTCAAAATGCCAGAgccaaagaaaagaaaaacaagctGGCGCTGCAGAAGGTCCTTGGTGGAAACGATTCAGATGTCCAAAGACTTCCTGAAGAATGCAAGCTATGTCAGTTCAAGTACTCACATAAGTACTCAGTACAAGACCATATCTTTACGAAGAAACACATAGACATGGTTAAGGCTTACCTGGAAAATCGGATGTCGAAGAACGAGTTATCTGGTAATGCGAGTGACAGTGAGTTTACCGTGCCACCAGCCCCAGTGGCTGGGGAAGTAAaccacaacaacaacaacacgaGTCAACAACACCAGCTGGCGCAACTGCAGATGCTTCAGATGGCCGGACTGTCGCTTCCGTCAGCCCAAGCCGTGGCGATGGCCTCTAAGATGGATGGCAAGGACCAGCAACAGCCCAGTCCTGAAGACATGGCACTCCTCCACCAGCTCTACGGGTTGGGCTTGGGCTTCCCTCAAGGATTTGTGCAATCAGCGATGCTCTCCGCGACGGGTAAGTTGACTGATCACAAGGCTTAG
Protein Sequence
MKVSTPTSQSDQHSQVQIDSTEDKASGDTHICPYCNYSSNSEMRIQAHVLAQHSQNERSPSASSPVREFLCPLCQDGFRDRPQLEKHVMQIHSVNSEGLQRLLMLVDQSHWLNNSSRQSQQQQTPPGHHHSPASVASSSGSKDQEKPNTSESSREEDKEEAQNLSSTDDQAEDENKCQTCQKTFRNIDELCLHQNESGHLELKQTPSGPGYLCWKKGCNQYFQTAHSLQMHFREIHARGGNATPAVAVSEKHVYKYRCSQCSLAFKTMEKLQLHSQYHLIRDATKCVFCGRSFRSILALHKHVETSHSELSDEELMAYKQSLMNNPLLLAGISGQILDPSTNELLRKESLKMECEEGMELEESPGKDNPDDSVNQTGDGENSDDSIVYKEQQFLEDYLNSQAIAEDSYNDPNRKYKCHRCKVAFTRQSYLTSHNKTLLHRKGEKLSYPMEKYLDPNRPYKCDVCKESFTQKNILLVHYNSVSHLHKLKRAMQEQQQQNNNNNPAVSPQTAASVAAAALAATLGVSSNQLTPKTPTAIDEDDKKPYKCNICKVAYSQGSTLDIHMRSVLHQTRASKLQDLAMTGQIDLSKPLIEQPEPQKAQDQHKKLIQDILGSSPKHTLLTSPPSSGSNGSQVPGSSPGSGNLVPSSISSTPNLTSVPTSIANNSSNSPSSVIPSPTQQGMVSCQRCSALFGSQEQLTTHQQLYCMFGSPMTMFPPLPTPPSSASNTLVQSLSSPSNKTPPPGPMTPLPEDTFPRVSIPSKKSSQMYKHLLESFGFDLVMQFNENHQRRQRKEREENEKLIAEISSTTPSVEEQPIETLVVSEQPEAPPPEPEVEVKVEEETPTVDLPEVAKSTCQHCNKEFSSVWVLKAHCEEVHRDLVPLDFLEKYAQQFKCEYEKKSVPTSSTSATNTTVTSTTSSGSDVTPEKDEDNKEAIHAKIGLSQTQSTPPDMTTAPSTPTAASTPASSTDSLPATISSTIAAVAAGMGGASNPNANLSMSLAQQMSEMQAALNVMAASQLQQQLQQFSPVMMGMAGLGMGLPLGLNMPALAAMNLQPPLVPMMMPPPPFDPLGGLGQGFNPQGSGIDPATLLAKQQQHLLQQQQQVVNASQQKRARTRITDDQLKILRAHFDINNSPSEDQIHEMAGQSGLPPKVIKHWFRNTLFKERQRNKDSPYNFNNPPSTTLNLEEYEKTGEAKVMPLNSSGSSTSTEDPSTPAKDAEKAPAVKSAPPPPPPPPPPPAPQQLPASPMQPPHKSGPQQSPMQQQQKQQSAMHHQSSFHQQTQSFPHPPDAIKKEPRDPISQQQLDEQKFTTMLMEAEQRMKREMVDEKPNIYPGQSLSPPSPHMNDRMNIIPARNNSPENLTLTSIISSQLGPESMSMNSPTQQMQVSHSNMLPPKLTPPNFTSPSHMGSSGMPLTPTSRSMSPGRSGSADCFSHAMLGGPNGNNSAGSSGKRANRTRFTDYQIKVLQEFFENNAYPKDDDLEYLSKLLNLSPRVIVVWFQNARQKARKVYENQPPVDPTPGLDDAGAGRFQRTPGLNYQCKKCLLVFQRYYELIRHQKTHCFKEEDAKRSAQAQAAAAQIAAVLSSEDSNSSTIVEQNQQNQLANLVGINTCSNPSTPAAPITPTPSQSVYPPSPVPPSTPTPDTKDSSFQCDNCNLVFPRFDLWREHQLVHIMNPNLFPSYPPDSPFGILQQHAQMQQQQHQQQQQQQQHQQQNTQQQQQHHMNNLVADLSMNPNSNQHPLISMLTSNKRKFDELEDMNERPQTGGADNEQPKDKRLRTTILPEQLDYLYQKYQIESNPSRKMLENIAREVGLKKRVVQVWFQNTRARERKGQFRAHSQVINKRCPFCPALFKVKSALESHLTTKHADQCSRGEINIDALPDEELSVESSHSFPSSQMGDSGAKMQNFSSSQLNQTMIPPMFPPFHGNMDDSLKKYYEESMKRYISELQAQHVTQNGAVTKEGLPSDLRVKSEGNGRAGESTGDCPLDLSKPVDLSRPIKMSLDHDIRAMMGDPGPLTDLSERSFCDDDSMSECTDNMEGDESNPTSPASSTQSRNPGQGGNKRYRTQMSSLQVKCMKSLFNDYKTPTMAECEMLGREIGLPKRVIQVWFQNARAKEKKNKLALQKVLGGNDSDVQRLPEECKLCQFKYSHKYSVQDHIFTKKHIDMVKAYLENRMSKNELSGNASDSEFTVPPAPVAGEVNHNNNNTSQQHQLAQLQMLQMAGLSLPSAQAVAMASKMDGKDQQQPSPEDMALLHQLYGLGLGFPQGFVQSAMLSATGKLTDHKA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01372135;
90% Identity
iTF_01372135;
80% Identity
iTF_01372135;