Snig015622.1
Basic Information
- Insect
- Stegana nigrithorax
- Gene Symbol
- lz
- Assembly
- GCA_037044495.1
- Location
- JBAMBQ010005158.1:1-10803[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 6.6e-17 2.5e-13 49.8 0.2 94 129 1 36 1 36 0.98 2 2 1.1 4.2e+03 -2.6 0.0 68 91 393 417 384 423 0.75
Sequence Information
- Coding Sequence
- AAAAGTTTCACGCTGACAATTACCATTTCCACGAATCCGCCACACATCGCGACCTACAACAAAGCGATCAAAGTGACTGTTGATGGGCCACGAGAGCCACGTTCGAAGACCATGTTATCGCTTTtagggcaacaacaacaattccaCTTCGCTTTCGGCCAAAGACCGTTCCATTTCTCAACGGATCCGCTATCTGGCTTTCGCATGCCGCCGATTGGAAATTGTCAAAGTGCCAGCAACACACACTGGGGCTATAGTTCGGCGGCCTCCGCTTATTCGCCGTACCTGGCCAGCAGCGGACTCTCGTCATGCACCACGCCGACCTCGGCGCAATTCAATAATCCGGCATTGGGCTTCACTTGCTCCTCCAATGATCAGACGAACAATCAGGACTTCACCGGAGCCACTAATCGCGACTGTGTGCCAATGTTGCCCGACTCGACGGCCAGTGACTTGGATCAGCATCTGAGCAATCTGGTTGGCTCCACCAGCGGCCAAATGACGCATCACAGCCTGCTCGGCACCAGCGGCCAAACCTCGATCTCATCGACAGTGaatggtggcggcggtggcgctGGCACTGGTAGCGCCAATTCAATACTAGTGCCGCGCTATCACACCAACACTAACAACGACTACAACGTGCATTCGAGCCAAAACGGGCCACGCAGCCTCAGCGATTCATCACAGGCCGAGTCACCGGTGCAGGAGGATCTGCTCTCGACAAATACACCCAATCTAGGCAGCGGAAGCGCCGGCGGCGGCAACAGCGGTAGCACGGGCGGCAACGCGAACAACGGTTCGTCCAGTTCAGGCGCCAGCGGTGGCACTGGTGCGGGCAACAATGCCATGGTGGGCGCCAATCAAAACTTCCCCGGGATTGTTAATCAGTCGCAGTCGCATGCCTCGGCCTATGGTAGCGGTTCTGGCGTTGGCGTCGGTGTGGGCgttggtgtcggtgtcggcAGCGGACCAACGGGAACGGCAGGCGCTGGCTGCAATGGCTCACTGTATCCAGTGCTGCCGGCGAGTCTTCTCTACTCTCAGCTGTATACGGCGGCCAATCAGACGGCGCACGGTTTTCACTCGCATGCGTTGCCGTCACACGCGTCGCCGAATTCGTCAGTGCATGGGGAGCTGCAGAGTGTCATGGATCATATTAGCAATGTGGGTGTGCGACAGCAACATAACATCATGGCCGGCGGCGGTGTGGCACATCCGGGCGATCTGACGCTGATCGGCAATTGCGGCGCTTCGGTGCGCAATATCGAGGATGGTAACACGAATCGCCAGGTGGCCGCCTTAGCTGCACACCGCGGCCACCACAATCCAACTGACAATGGCGGCAGTGTTTGGCGACCATATTGA
- Protein Sequence
- KSFTLTITISTNPPHIATYNKAIKVTVDGPREPRSKTMLSLLGQQQQFHFAFGQRPFHFSTDPLSGFRMPPIGNCQSASNTHWGYSSAASAYSPYLASSGLSSCTTPTSAQFNNPALGFTCSSNDQTNNQDFTGATNRDCVPMLPDSTASDLDQHLSNLVGSTSGQMTHHSLLGTSGQTSISSTVNGGGGGAGTGSANSILVPRYHTNTNNDYNVHSSQNGPRSLSDSSQAESPVQEDLLSTNTPNLGSGSAGGGNSGSTGGNANNGSSSSGASGGTGAGNNAMVGANQNFPGIVNQSQSHASAYGSGSGVGVGVGVGVGVGSGPTGTAGAGCNGSLYPVLPASLLYSQLYTAANQTAHGFHSHALPSHASPNSSVHGELQSVMDHISNVGVRQQHNIMAGGGVAHPGDLTLIGNCGASVRNIEDGNTNRQVAALAAHRGHHNPTDNGGSVWRPY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00352332; iTF_00251126; iTF_00062521; iTF_00891642;
- 90% Identity
- iTF_00062521;
- 80% Identity
- -