Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 2.7 2.2e+02 3.0 0.0 1 17 94 110 94 111 0.93

2 7 0.19 15 6.6 0.2 2 20 158 176 157 178 0.89

3 7 0.00051 0.041 14.7 0.3 1 23 187 209 187 209 0.98

4 7 0.049 3.9 8.5 0.1 1 23 215 237 215 237 0.93

5 7 6e-05 0.0048 17.6 1.2 2 23 244 265 243 265 0.97

6 7 4.3e-05 0.0034 18.1 3.8 1 23 270 293 270 293 0.97

7 7 3.9e-05 0.0031 18.2 1.5 1 23 299 322 299 322 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	2.7	2.2e+02	3.0	0.0	1	17	94	110	94	111	0.93
2	7	0.19	15	6.6	0.2	2	20	158	176	157	178	0.89
3	7	0.00051	0.041	14.7	0.3	1	23	187	209	187	209	0.98
4	7	0.049	3.9	8.5	0.1	1	23	215	237	215	237	0.93
5	7	6e-05	0.0048	17.6	1.2	2	23	244	265	243	265	0.97
6	7	4.3e-05	0.0034	18.1	3.8	1	23	270	293	270	293	0.97
7	7	3.9e-05	0.0031	18.2	1.5	1	23	299	322	299	322	0.96

Coding Sequence: ATGACCTCTactttaataattcaaaaaatgATGTCAGTAAAACTAAGTAAAGGCGaattcgaaaaaataaaatggcttaGAGCGAATAATAAAgagaaaacttttaaaacaatatcATCACTGAGaacattattacaaaatcaaaagTATAGAAAAACTTGCAGACTCTGCCTCAAACCGGGTAGCAAGAAAATGTTTGATAGCAATGATTTTGATATAGCCTTTGTTATTAAGCAACTGTTGCAGATAGAGGTAACCAAAGATGATGATAAACCACAATACATTTGCAAAGCATGTGAAGTGGTACTCCGGAATGCTGACCAGCTGAGGCAAACGGCTGAAGTGACTCAGTGGAGACTGCAACAGGAACTTGAATTAATGACCAATATGGAATCAGACACGGAAGAGAATGAGAAAACGCCTCATGGAGGCTACTTTGTAAAAAAAGGTACGACTGTCGTGCGAGAGTGGATTTGTGGAAAATGCCGACAAACATTTGATAGCCAGAAAGTATTCATGGAACATGAGAAACTGCCGTGTTCTCGTGGCGATAAGAGTTTTGTATGTGAAACATGTGGCTTGGAACTGAAGTCTATGACGCGGTTAAAGAGACACATgctTATACATACAGGGGAGCTGCAGTATCCATGTATTCAGTGCCCATATCGCGCTCGTACTAAGTACGCCCTGATGGTCCACGAGCGAGCTCATAGCGGTGAGCGGCCCCTGACCTGTCCGCACTGCCCAGCTACCTTCCTCAATTCTTCAAACCTTGCCTCACATAAGAGGAGACATCTACCACCAGCTTATCACTGTCATGTATGTGTCAAGAGCTTCAGATTTAAGGAGgCGCTGCAAAATCATTTAGCCACACAACACAGCACAGCCAAGCCTCATGTCTGCAATGCATGTGGAAAAGCCTTTTCAACCAGAAAGATGATTCGGCGTCATGAACGTAGGGTCCACAATAGACCGAAACTGCGTTCCGGAATCGTGCCTACATACTTACGACAGCTGCAGCAGGAACAAATTACATAG
Protein Sequence: MTSTLIIQKMMSVKLSKGEFEKIKWLRANNKEKTFKTISSLRTLLQNQKYRKTCRLCLKPGSKKMFDSNDFDIAFVIKQLLQIEVTKDDDKPQYICKACEVVLRNADQLRQTAEVTQWRLQQELELMTNMESDTEENEKTPHGGYFVKKGTTVVREWICGKCRQTFDSQKVFMEHEKLPCSRGDKSFVCETCGLELKSMTRLKRHMLIHTGELQYPCIQCPYRARTKYALMVHERAHSGERPLTCPHCPATFLNSSNLASHKRRHLPPAYHCHVCVKSFRFKEALQNHLATQHSTAKPHVCNACGKAFSTRKMIRRHERRVHNRPKLRSGIVPTYLRQLQQEQIT

Sequence clustering based on sequence similarity using MMseqs2