Ssim018628.1
Basic Information
- Insect
- Spicauda simplicius
- Gene Symbol
- Runx1
- Assembly
- GCA_949699795.1
- Location
- OX453073.1:6746647-6765709[-]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 7.9e-74 4.9e-70 233.9 0.0 4 129 45 170 42 170 0.98
Sequence Information
- Coding Sequence
- ATGCATTTATCGAGTGAAGTTAGTTCCACGACGAACGGACTGGGCCACGAGGCCCCATCATCTAGTTACGGCAGTAGTTTAGCCAGTCAGCCATTGACGGCTGAGTTGTTAGCGGAGCGGACCCTGGAAGGTCTGTTAGCTGATCACCCTGGGGAGCTGGTGAAGACCGGCAGTCCACATGTTGTATGTACTGTACTGCCCCCTCACTGGCGGTCGAACAAAACCCTAccagtggcgttcaaagtggtGGCTCTGGGAGACGTCGGCGACGGCACGCTGGTCACGGTACGGGCGGGAAACGACGAGAACTGCTCCGCGGAGTTGAGGAACTGTACAGCTGTTATGAAGAACCAGGTCGCCAAGTTCAACGACCTAAGATTCGTTGGGAGAAGCGGGCGAGGTAAATCATTCACCCTGACGATCATGCTGGCGACGTCTCCACCGCAAGTGGCGACTTACCAGAAGGCGATCAAGGTCACGGTGGACGGTCCACGGGAGCCTCGCTCGAAGACAAGGCACCACGGCTTCCACCCCTTTCACTTCGGGCCACGGTTCGCACCAGACCCCCTTATGGGCTCCTTGCCTTTTAAGTTATCaggtaattattaa
- Protein Sequence
- MHLSSEVSSTTNGLGHEAPSSSYGSSLASQPLTAELLAERTLEGLLADHPGELVKTGSPHVVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTLVTVRAGNDENCSAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIMLATSPPQVATYQKAIKVTVDGPREPRSKTRHHGFHPFHFGPRFAPDPLMGSLPFKLSGNY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00674085;
- 90% Identity
- iTF_00008673; iTF_01362273; iTF_00444880; iTF_00674085; iTF_00970182; iTF_01251526; iTF_00449896; iTF_00289399; iTF_00994142; iTF_00467968; iTF_00796297; iTF_00063353; iTF_00235648; iTF_00680293; iTF_00113909; iTF_01133495; iTF_00682143; iTF_00761399; iTF_00834398; iTF_01452108; iTF_01569037; iTF_01403218; iTF_01436789; iTF_00662006; iTF_01443606; iTF_01279959; iTF_01080504; iTF_00197149; iTF_01340925; iTF_00821549; iTF_00420319; iTF_00677311;
- 80% Identity
- -