Basic Information

Insect: Sphenella marginata
Gene Symbol: topi
Assembly: GCA_951509765.1
Location: OX608079.1:113140767-113144297[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 10 5.5e-05 0.0085 18.0 2.6 1 23 275 297 275 297 0.97

2 10 0.032 4.9 9.3 1.1 2 23 332 353 331 353 0.97

3 10 0.06 9.2 8.4 0.1 2 19 415 432 414 434 0.94

4 10 0.061 9.4 8.4 2.3 1 22 483 504 483 507 0.90

5 10 1.1 1.7e+02 4.4 0.2 2 21 522 541 521 544 0.79

6 10 1.7e-06 0.00027 22.7 2.3 1 23 564 586 564 586 0.95

7 10 0.004 0.62 12.1 1.1 1 23 592 617 592 617 0.95

8 10 0.6 92 5.3 1.7 1 23 623 645 623 645 0.88

9 10 5.1e-08 7.8e-06 27.5 0.4 1 23 651 673 651 673 0.99

10 10 0.058 8.9 8.5 1.4 3 23 681 702 679 702 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	10	5.5e-05	0.0085	18.0	2.6	1	23	275	297	275	297	0.97
2	10	0.032	4.9	9.3	1.1	2	23	332	353	331	353	0.97
3	10	0.06	9.2	8.4	0.1	2	19	415	432	414	434	0.94
4	10	0.061	9.4	8.4	2.3	1	22	483	504	483	507	0.90
5	10	1.1	1.7e+02	4.4	0.2	2	21	522	541	521	544	0.79
6	10	1.7e-06	0.00027	22.7	2.3	1	23	564	586	564	586	0.95
7	10	0.004	0.62	12.1	1.1	1	23	592	617	592	617	0.95
8	10	0.6	92	5.3	1.7	1	23	623	645	623	645	0.88
9	10	5.1e-08	7.8e-06	27.5	0.4	1	23	651	673	651	673	0.99
10	10	0.058	8.9	8.5	1.4	3	23	681	702	679	702	0.95

Sequence Information

Coding Sequence: ATGATGAACACAAGTGAAGAGGAATTTACCAATTCAGATGCTTGGCTATCGGAGCAACTATTCGCGCAGCTTAAAGAATTCAATTCTGATTACAGAGATAAGTCGATGACGGATGCAACGGGGGCATTTGTATTTCCATCGGGAAGTCTCAATTTTTCACCGGAAGAGGAGCCGCAAGATTTAACAAAATCGAgaattgaaacaaattttgattcGGTTTTTAAAATGccaacacaaacaaatataccACCATTCGATGTGAATGATGTTTTGGATTTGAGCAACATTTCTGGTAGAGGCAGTGACGCAGCACTTTTAGATTTGGTAGGCACGGTACCTTTGACACCATTTCCACCTACGGTTGTTGAGTCCCCAGTTGTGGTAGAAGAAGCCGTGAAAAATgtaacaataatgccaacattTGATGCGACAGAAGAAGAAATGAAACTTTTGAAGTTTCTGGAATCTCAGCCGCAGAGCAATACTCTTGATACTAAACTATACATTCCACCCGAAATACAACCAACTCCTTATCGCATAGTGAAATGTTCAAATTGCAGTTGCCTCTTCGACATCATTTCTTTTCAAAGTCATGTTTGTGATTATGATGAACATCACAATTTAATCATTGCGCCTGCAACATCAACTCCCATTAGTAAACCACCTCCAATTAAAGAGGAACCTTTATTGCCGCCAGAACCCGCATGTATTCGTTTATTGCGTGAAAATCAAATACGTATACGACGCTTTTTAAAAGATGAACTTAAATATGATGTGAATGctttaaataacaataattcaAACTCATCAAATAATGGACCTCACGAGTGTACTTTGTGTGAGCGTAAATTTGTACATGCTTCGGGTTTATTGCGTCATATGGAGAAACATGCAATGGATCTTATACCTACACCAGGTGGTTCTTCGAATGGTAAAATGGCAGCAACACAAGGCAGTTCCTTGCAGAGTGTGAATGGTTTGCGCGTTGTTATTAAATGTACGCTGTGTGGACGTATATTCTTCGAACCTGTCACAGCTTTTAAACATTTATGCTCCCATTTTCCGGGTAGTATGCAGGAGGAAAAAGAAATGGATAATTGTACTGAAATACCATATGAATCTTACGTGGATGATGCtatgaactttttaaaaatggagGCAAAAAACTGTTCAGGTGCCCTAACCATTCACGAGGACAAGCCTCCAGTTTATCTTAAAATGGTTATTCTTAGCTGCATCTTGCAATGTGAATTTTGTGACTTTGTCTTCTCGGAAGTATCCTACCTCTTCGTACACTCTGCTTGTCATTTACCTGAGCGCCGCTTTGAATGTTTCTCATGTGACATACATATGCGTACATCCAAGGAGATTTGCGCACACTGGCAAGCTGAATGCGTATTTATGCGcgagaatttaaaaattcatcaAGCCACCACACAACGTTATTTCGTGTGTAATGTGTGCGAGAATAAATTTCAAACACTTGATCAGTTGCATGAACATCGTTACACTTCGTACCATTTCTTTCCACGCCTTAACAAATGTTTGGGTGTACTGCAGCTCCCGTGTGAATATTGTGATGTAGTTTTCGAATATGCACAAGAATGTGTGGCTCATTACGAGGAAAAGCATTATAAAAAGTATAAACGCGATAAAGATGGGACAGGTTCTTCAAGTAAAACGCGCCAATATTTGTGTGATATGTGTGGAAAATCTTATACACAATCGAGTCACCTATGGCAGCATTTACGTTTTCACCAAGGTGTGAAACCATTCGCTTGCAAGGAGCCTGGTTGCACGCGTAAATTCACCATTCGTCCCGACTTAAATGATCATATAAGAAAATGTCATACCGGTGAGAGACCCTATCATTGTTTGGTATGTGGCAAACGTTTCTTAACAGGGTCAGTTTTCTATCAACATCGTCTTATTCATCGTGGCGAACGTCGTTATGAGTGCGAAGAGTGTGGCAAACGTTTTTATCGTGCAGATGCTCTTAAAAACCATCAACGTATTCACACTGGTGAGAAGCCATTTGGTTGTCTTTTTTGCACAAAGAATTTTCGTCAACGCGGTGATCGTGATAAACACATAAGAGCGCGCCATTCTCATCTAGATGCCAATGCACGTCTAATGATGCAAATGCAAAAGCTACAGCTCGAAGCTGCTGCAGCAGCCGCCGCGGCACAAGTCGCTGTTCAGCAACAGcatcaccaacaacaacaacatatccaTCACCaatatcagcaacaacaacaacaccaaactCAGCTCCCAAATAACGGCACTATTATGAACGAAATACCCACCGTTACACCCACCCTAATGAGTATGCCATCTGTAAGCAATGATATAATTGATGGTTTGGAACCATCATTAGATCCAAATGACGTAGTCATGATAGGTAATGTAGCGTTTCCAAAGAGTATGTTTGAATCAATAATTCCCGATATTGATGAAGAGTCTGCATTACGAGCCATGGAACAATTGCAATAA
Protein Sequence: MMNTSEEEFTNSDAWLSEQLFAQLKEFNSDYRDKSMTDATGAFVFPSGSLNFSPEEEPQDLTKSRIETNFDSVFKMPTQTNIPPFDVNDVLDLSNISGRGSDAALLDLVGTVPLTPFPPTVVESPVVVEEAVKNVTIMPTFDATEEEMKLLKFLESQPQSNTLDTKLYIPPEIQPTPYRIVKCSNCSCLFDIISFQSHVCDYDEHHNLIIAPATSTPISKPPPIKEEPLLPPEPACIRLLRENQIRIRRFLKDELKYDVNALNNNNSNSSNNGPHECTLCERKFVHASGLLRHMEKHAMDLIPTPGGSSNGKMAATQGSSLQSVNGLRVVIKCTLCGRIFFEPVTAFKHLCSHFPGSMQEEKEMDNCTEIPYESYVDDAMNFLKMEAKNCSGALTIHEDKPPVYLKMVILSCILQCEFCDFVFSEVSYLFVHSACHLPERRFECFSCDIHMRTSKEICAHWQAECVFMRENLKIHQATTQRYFVCNVCENKFQTLDQLHEHRYTSYHFFPRLNKCLGVLQLPCEYCDVVFEYAQECVAHYEEKHYKKYKRDKDGTGSSSKTRQYLCDMCGKSYTQSSHLWQHLRFHQGVKPFACKEPGCTRKFTIRPDLNDHIRKCHTGERPYHCLVCGKRFLTGSVFYQHRLIHRGERRYECEECGKRFYRADALKNHQRIHTGEKPFGCLFCTKNFRQRGDRDKHIRARHSHLDANARLMMQMQKLQLEAAAAAAAAQVAVQQQHHQQQQHIHHQYQQQQQHQTQLPNNGTIMNEIPTVTPTLMSMPSVSNDIIDGLEPSLDPNDVVMIGNVAFPKSMFESIIPDIDEESALRAMEQLQ

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00081676;
90% Identity: iTF_00993064;
80% Identity: -