Sjav001889.1


Basic Information
Transcription Factor Domain
Sequence Information
Similer Transcription Factors

Basic Information

Insect
Sphaerogastrella javana
Gene Symbol
Runx1
Assembly
GCA_037040025.1
Location
JBANCZ010000244.1:1-9561[-]

Transcription Factor Domain

TF Family
Runt
Domain
Runt domain
PFAM
PF00853
TF Group
Beta-Scaffold Factors
Description
The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 3 6 1.1e+05 -10.9 9.7 59 67 25 33 9 60 0.61
2 3 4.5 8.5e+04 -4.3 1.9 59 67 64 72 42 80 0.56
3 3 4.3e-74 8.1e-70 235.0 0.0 3 129 108 234 106 234 0.98

Sequence Information

Coding Sequence
ATGCATTTGACAACCACGGGCAGTAATTCAACTGCtggcaatgccaacaacaacaacaacaacaacaataataacaacaacaacaactccgcaaacagcaacaacaacaacaatagcaattcaaccagtagcaacaacaatgcaagcAACACAAAtggcaccaacaacaacaacaacaacagcaacaacaacaacaacaacaactccagcAATtcgaacaacaacacaacCGAACAGAACACACCACCAACACCCGCCCAACTGTTGAACGAGGCCTACACCAAGATGACCTCGGACATCCTAGCTGAAAGAACCCTTGGAGACTTCCTTACCGAACATCCCGGTGAGCTAATTCGAACAAGCAGCCCCCTCTTCGTGTGCACCGTTCTGCCACCACATTGGCGCTCCAACAAGACGCTCCCGGTCGCATTCAAGGTCGTCTCCCTGGGCGACATCATGGATGGCACCATGGTCACAGTGCGCGCTGGCAACGATGAGAACTACTGCGCCGAACTCCGCAACTGTACCGCTGTCATGAAGAATCAAGTGGCCAAGTTCAATGATCTGCGATTTGTGGGACGCAGCGGTAGAGGGAAGAGCTTCACATTAACCATCACCGTGTCAACAAATCCACCACACATAGCCACCTACAACAAGGCGATTAAGGTGACTGTCGATGGGCCCCGTGAGCCACGATCCAAAACCa
Protein Sequence
MHLTTTGSNSTAGNANNNNNNNNNNNNNNSANSNNNNNSNSTSSNNNASNTNGTNNNNNNSNNNNNNNSSNSNNNTTEQNTPPTPAQLLNEAYTKMTSDILAERTLGDFLTEHPGELIRTSSPLFVCTVLPPHWRSNKTLPVAFKVVSLGDIMDGTMVTVRAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTITVSTNPPHIATYNKAIKVTVDGPREPRSKT