Basic Information

Gene Symbol
-
Assembly
GCA_014356515.1
Location
chr3:18312062-18317158[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00017 0.0088 16.7 1.2 1 23 166 188 166 188 0.99
2 10 6.8 3.5e+02 2.2 0.1 15 23 205 213 203 213 0.91
3 10 0.0022 0.12 13.1 0.4 1 23 219 241 219 241 0.97
4 10 0.0016 0.081 13.6 0.2 1 23 251 273 251 273 0.98
5 10 1.1 55 4.7 0.1 1 20 280 299 280 301 0.88
6 10 1.5e-05 0.00076 20.0 0.7 1 23 314 336 314 336 0.98
7 10 1.2e-06 6.2e-05 23.4 8.6 1 23 342 364 342 364 0.98
8 10 0.00014 0.0074 16.9 1.5 1 23 370 392 370 393 0.95
9 10 0.00019 0.0099 16.5 0.1 1 23 399 421 399 421 0.98
10 10 0.0074 0.38 11.5 0.2 2 23 430 451 429 451 0.97

Sequence Information

Coding Sequence
ATGACAAAGATTCTGGTGGTGGTGGTGGTGGCGAAACTTTGTAGTTACATGGCCACAAAGAAATCTTCAAGTGGAAGGCGTGAGAATGAAGAATGTGGAGAGCTAGAACAGTGGGAAGATCCCAGAAGTTTTGTGGCTGTCAACATGGTCCTTAGTGAAACAGAATCTACTGAGGAAGAGGATAATAATAAAGAATCAAGATGTTGTGCTAGCATACAGACGAATGGGCCAGAAAATGAAGTCCAAGCAGTTGCTGCATGTAATGAAGAACGGGGCTCAAATTCCAATACAGATGGCACATTCAATTCGTGGAACGATCCCAGGTATTTTGTTGCTGTCAGGATGGAACAAAGCAGTGACTTCTCTGAGAGCGACAGCTTGGTACAAGGCCACCAGGGCGGAGGCGATGGAATGGCAGACTCAGTGAATATGGTCGCGCAGTCTCCAACTGTGATCGATCAGCAACACCAAGAGTCGCAGACAACCAAACCATACTTCAAGTGTGAAGTGTGTTCAATGGCGTTCGAAGACGAAGACTGCTACGAATCTCACATGAAGATGCACATTCAGCAGATACCCTGCAACGTATGCGGCTTACTGATGTTGGTCGGCGACCTTGAAAAGCATATGGAAATGCACGCGCGTAGTCCTGTTCACATCTGTCGAGTGTGCAATGTCGGATTTCAATCGATCGAACAGCTGATCACACACATACGCTCACACAACAGTATTTGTCCCAACGACCGGCCCTACAGTTGTCAGCTGTGCGACACGGCGTTTCAAAAGATTGAAGCGTTGCGTGCACACGTCAAACAGCACAGGGAAACCGAGAAACCGTTCGTTTGTATCACGTGTGGCTCGCTATTTGTAAGCAGTGGAGAGTTGAAAACTCATTCAATGTCTTGTAAACAACAGCAGCAGCCCGAAGAGAGCCCAGCGTTTGTTTGTGAAACGTGTCGGAAGTCGTTCACAGAAAAAGATTCCTACATAGCTCACCTGAGGGAGCACACTGATGAAAAGTCACACAAGTGTGACATATGCAACACGTGTTTCACACGTAAACGATACCTGACAAAGCATATGAGAACGCATGCTGGCAAGCGACGCTATGATTGTCCCATATGCAGCAGTTCGTTCTACCAGGAGGTGCACCTCAACATGCACATGGAAATCCATCACGTGTCCGAGCGTCCGTTTGTTTGTGACAGATGCAACGAGGCATTCACCGAACAAGGCCTCCTTGAAGATCACTTGGAAATGCATAGGAGGAAGGAGCGCTCCACTCTAAGGTGTCCAGTGTGTACGCTGCCTTTTCTACAGAAGGTAGCTTTTGATAGGCACATCAGAAAGCATTTCCAGGAGGAAGAGGATCGCTTAAGGAATGCGGCCTTGTGGAATAATTGA
Protein Sequence
MTKILVVVVVAKLCSYMATKKSSSGRRENEECGELEQWEDPRSFVAVNMVLSETESTEEEDNNKESRCCASIQTNGPENEVQAVAACNEERGSNSNTDGTFNSWNDPRYFVAVRMEQSSDFSESDSLVQGHQGGGDGMADSVNMVAQSPTVIDQQHQESQTTKPYFKCEVCSMAFEDEDCYESHMKMHIQQIPCNVCGLLMLVGDLEKHMEMHARSPVHICRVCNVGFQSIEQLITHIRSHNSICPNDRPYSCQLCDTAFQKIEALRAHVKQHRETEKPFVCITCGSLFVSSGELKTHSMSCKQQQQPEESPAFVCETCRKSFTEKDSYIAHLREHTDEKSHKCDICNTCFTRKRYLTKHMRTHAGKRRYDCPICSSSFYQEVHLNMHMEIHHVSERPFVCDRCNEAFTEQGLLEDHLEMHRRKERSTLRCPVCTLPFLQKVAFDRHIRKHFQEEEDRLRNAALWNN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00366016;
90% Identity
iTF_00857942;
80% Identity
iTF_01354071;