Basic Information

Insect: Smittia aterrima
Gene Symbol: topi
Assembly: GCA_033063855.1
Location: CP093831.1:1067060-1069275[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 15 0.0044 0.18 12.3 7.9 1 23 173 196 173 196 0.96

2 15 0.02 0.83 10.2 3.0 1 23 202 224 202 224 0.95

3 15 0.053 2.2 8.9 0.8 3 23 235 256 233 256 0.95

4 15 0.037 1.5 9.4 2.3 1 23 263 286 263 286 0.97

5 15 0.0052 0.22 12.1 0.5 2 23 294 316 293 316 0.94

6 15 0.048 2 9.0 0.2 3 23 325 347 323 347 0.94

7 15 0.00013 0.0054 17.1 0.9 3 23 355 376 354 376 0.96

8 15 0.2 8.2 7.1 1.2 1 23 382 404 382 404 0.96

9 15 0.18 7.5 7.2 0.5 2 23 414 436 413 436 0.91

10 15 0.016 0.67 10.5 2.5 5 21 444 460 441 463 0.93

11 15 0.0014 0.06 13.8 3.2 3 23 471 492 469 492 0.94

12 15 6.6e-06 0.00027 21.2 1.4 2 23 498 519 497 519 0.96

13 15 2.4e-05 0.00098 19.4 0.6 1 23 524 548 524 548 0.98

14 15 0.0012 0.048 14.1 5.1 3 23 556 577 554 577 0.93

15 15 0.0002 0.0083 16.5 0.9 1 23 582 605 582 605 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	15	0.0044	0.18	12.3	7.9	1	23	173	196	173	196	0.96
2	15	0.02	0.83	10.2	3.0	1	23	202	224	202	224	0.95
3	15	0.053	2.2	8.9	0.8	3	23	235	256	233	256	0.95
4	15	0.037	1.5	9.4	2.3	1	23	263	286	263	286	0.97
5	15	0.0052	0.22	12.1	0.5	2	23	294	316	293	316	0.94
6	15	0.048	2	9.0	0.2	3	23	325	347	323	347	0.94
7	15	0.00013	0.0054	17.1	0.9	3	23	355	376	354	376	0.96
8	15	0.2	8.2	7.1	1.2	1	23	382	404	382	404	0.96
9	15	0.18	7.5	7.2	0.5	2	23	414	436	413	436	0.91
10	15	0.016	0.67	10.5	2.5	5	21	444	460	441	463	0.93
11	15	0.0014	0.06	13.8	3.2	3	23	471	492	469	492	0.94
12	15	6.6e-06	0.00027	21.2	1.4	2	23	498	519	497	519	0.96
13	15	2.4e-05	0.00098	19.4	0.6	1	23	524	548	524	548	0.98
14	15	0.0012	0.048	14.1	5.1	3	23	556	577	554	577	0.93
15	15	0.0002	0.0083	16.5	0.9	1	23	582	605	582	605	0.97

Sequence Information

Coding Sequence: aTGGACGGAACgaaatttgaagaagttgaCTACTCTCATCATGAGATCAAATGCCGTTTATGCTTCAAGCTCTTTGGTCATGACGAGCATCGCttagaaatatcaaaagcggtcgagagaaaattccGCGAAGTTACACAAACAGACTTAAAACTACTAGAGTCCTTCTCAAGACACATCTGTGTAGTTTGCAACTTCCAGCTCAAGGATTTCTGTCTCTTTCGaagaaatgtaattttaCTCCAAAAAGGACTCTACAAGTTTGCTTCAACTGCTCGAAAGGATTTTAACTTACTTAACGAAGAAAATGTGGAACCTGACATTgcaatcaaagaagaatttgacGAATACTGTgaaggaaatgaaacaaacgTTGAAGCTGATATAAAAGTCTTCGATCAACCGCAGAGCGAATTCTTAGACTTTAACTGCGACTTAAATTTCGATCGATCTCCTTATatgaaagatgaagaatCAGATCAGGTTGAAGATCCACCAAACTCAGATGACAGAAACTTCAATTGCGAATCCTGTAATCTTAGTTTCTCTCATCAGTGTCAGCTCAATCGCCATCACAACAGAGTTCATcttaaagtgaaaaactttgcgTGTGATCAATGCGAgtacaaaagtttcttcaagcATAGCTTGAACGAGCATATGTTGACACACGTTCCTTTGGAGAACAGAGAAAGTCATTTATGTGATCAATGtgagtttatttcaatatCAAAGGCTTCTTTAAGCATTCATCAAAGGAAAGTTCATTCTACGACTCAACGGATGTACGAATGTTCTGAATGCTTTACGATCTTTGATTCGTATCAGTCTTACTACAAGCACAAGATGAAAGAACACGCattcgagaaagaaaaatgggTTTGTAATCACTGCTACACATCATTTAGTGGTGTCCGAGCTCTTCGTGATCACATAACTGTCTATCACGACAAAATTAAACCTCAAATCCCCTGCCCAGTGAAAACCTGCACAAAAGTCTTCCTTACTACGAAACGCCTTCGAGCTCACATCAAAGTGCACGACGACGACGCCAAAGAAATGTGCCCCGAGTGTGGCTTGTTGTTGACCAGCAAGCACAATCTTCAGAAACATATAAATAGAGTTCATTTAAAGTTGAGGAACTTTTTCTGCGATCTTTGCGACTACAGCGCAACTTTTAGACACAGCATCGCGTCTCATATGgTGAGTCACATCGATCCAAacgaaagaaggaaatggaATTGTGACTCTTGCAACTTTGTATCAGTTTCGAAGCAGTCACTGAGAGCTCATAAATCTTACGAGCATTCTGGAAAGGTCTACACTTGTCATTGTGGAAAGGAATTCAACCAAAAAGCATCCTTGTCAACTCACATAAAATGTGTTCATCATAAGATTAAAGATCATTTGTGTAACTTatgTGGTAAAGCTTATTTCTCCCGAAACGACCtcaaaaatcacaaaaagtCTCAGCATATGGAGAAATCGATGCCTTGTGAAATTTGTGGAAAGCTTTTCGCCACTCAAAAGCATCTGACACGTCACAGAATGTATCACGATGAGCCAAAGTACAAATGCAACTTCGAAGGTTgtacaaaagctttcatcgaCAACGCCAAACTTAAAGATCACATGAAACTTCATGAAGGAAATCGCGATCATCTCTGTCATCTCTGCGAAAAAAGTTATTACCATCAAAAGGATCTAAAGCGACATTTGGACGTTGCACACAAGGCGACCATTTACTATTGCGAGATTTGCACGTTTACGATCAGTCGAAAGGATTATctgagaaatcatttaaattctgcgcataaatatttgacgCTCGAAcagaaaaacgaaatcttAGCTCGAACCAAAGTTACAAGAAACGCagtttaa
Protein Sequence: MDGTKFEEVDYSHHEIKCRLCFKLFGHDEHRLEISKAVERKFREVTQTDLKLLESFSRHICVVCNFQLKDFCLFRRNVILLQKGLYKFASTARKDFNLLNEENVEPDIAIKEEFDEYCEGNETNVEADIKVFDQPQSEFLDFNCDLNFDRSPYMKDEESDQVEDPPNSDDRNFNCESCNLSFSHQCQLNRHHNRVHLKVKNFACDQCEYKSFFKHSLNEHMLTHVPLENRESHLCDQCEFISISKASLSIHQRKVHSTTQRMYECSECFTIFDSYQSYYKHKMKEHAFEKEKWVCNHCYTSFSGVRALRDHITVYHDKIKPQIPCPVKTCTKVFLTTKRLRAHIKVHDDDAKEMCPECGLLLTSKHNLQKHINRVHLKLRNFFCDLCDYSATFRHSIASHMVSHIDPNERRKWNCDSCNFVSVSKQSLRAHKSYEHSGKVYTCHCGKEFNQKASLSTHIKCVHHKIKDHLCNLCGKAYFSRNDLKNHKKSQHMEKSMPCEICGKLFATQKHLTRHRMYHDEPKYKCNFEGCTKAFIDNAKLKDHMKLHEGNRDHLCHLCEKSYYHQKDLKRHLDVAHKATIYYCEICTFTISRKDYLRNHLNSAHKYLTLEQKNEILARTKVTRNAV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -