Basic Information

Gene Symbol
topi
Assembly
GCA_002938485.2
Location
NW:4878712-4893893[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.0034 0.18 12.0 3.0 2 21 95 114 94 115 0.94
2 14 4.6e-07 2.4e-05 24.2 0.3 2 23 143 164 142 164 0.97
3 14 0.083 4.3 7.7 0.6 3 23 171 191 170 191 0.95
4 14 0.28 15 6.0 0.2 2 13 210 221 209 227 0.85
5 14 3.7e-05 0.0019 18.2 1.7 2 23 255 276 254 276 0.97
6 14 7.1 3.7e+02 1.6 1.1 1 19 282 300 282 303 0.78
7 14 0.076 3.9 7.8 3.3 2 21 319 338 318 342 0.85
8 14 0.0033 0.17 12.1 0.3 1 23 457 480 457 480 0.96
9 14 0.16 8.1 6.8 1.7 1 23 484 506 484 506 0.92
10 14 7e-07 3.7e-05 23.6 2.4 1 23 512 534 512 534 0.98
11 14 0.019 1 9.7 0.2 1 23 540 565 540 565 0.96
12 14 0.12 6.4 7.1 3.3 1 23 571 593 571 593 0.86
13 14 2.5e-05 0.0013 18.7 1.6 3 23 601 621 599 621 0.97
14 14 1.1e-05 0.00058 19.9 0.7 1 23 627 650 627 650 0.98

Sequence Information

Coding Sequence
ATGAGCTACACTGTCGTGATCCTGATGCACAAAATCGTCGACGACCGGATCGTATCTACGGTCAGAGACGAAAAAAACTCTAGACTCGCCCTGGATATGGTGATGCGAACGTACCTCAACCCCGACAGAATTAGACTGAATATATCGAATTATAGTGAGGAGAAGGTAAGTTTAAATATCGACGATCACTTGCATATCCAGGATTCATTGGTGATAGAGGCGCTCAATGAGAACGAGATGATAATGTACGAGCGAATGAATTTGAATTTTCCTACGTTGACCAAGTGCCAGAATTGCGAAACGAATTTTCCGACGAAATATCAGTATCAGCGGCATCAGTGCGATTTTGACGTCAACAAGGTGGTTTTCAAAACCTGCCCTGACGATGAAATTGCAGAAAATATaacagaaaataagaaaaaaacagagtGCGAAATATGCGGCAAGTTTTTCGCGAGCAAAATTAACCTGGAAAAACACCAAGAGACCCATTCCGCTCACGATAATATCTGCGAGTTTTGTGCGAAGCGGTTTGTCAGCGAAAACCGGCTGAGAATTCATAAGGAAAATCATTGCAAGAAGGCGGGTGACGTTGCCAAGTTTTATCGCAGCGATGTTACAGTGTGGAAGTGTAGAAAATGCCACGAAGTGTTTTCTTCCGCTGAAATTGCGGTGCATCACGTAGAAATTTGTCAGGAATCTGGAGATAATAACGAAAACAAGGAAAACTTTATCGAGAAAATTTCTACCGAGATTCTGCTGCAGTGCGAGTTCTGTAACAGAACTTATTCTGATAAAAATCTGTTATTGATGCACCAAAGAAAGCACACTACCGCAAAAAACTACGAATGCGTTAACTGTTTGAGGACTTTTGACTCTTTTTGTACGGCTTCGTCTCACTGGCTGAAAAAATGCAcggaattttcaaatttattttacttaccTCGATTGTCTTACTGCGAGTACTGTGATCGCACGTTCAAGTCTCACGATATCCTCTACAATCACAAAACAAAGAAGAAGCACTATACCCCGAAACTACATTCGCGTGCGGATGGCCCGCAAAAGCTTGACGAAGATGGAGAAGTAAAACCGTTGATTGAGAATAAGGATATTGTGAACAAACTTATAGAGGATGTGCTAAAAACTCTAGAGGTACCTGTGAATGACTTGGATGATGGAGGTGAGGTCCAAATGCAAGAGATCAAGGTGAAAATTGAACCCGGAGTGGAAGATCTTTCAAGTTCTAGGTTGGAGCAGGAAATTATAGAAGAACAGATAAAACCACCTAAAAAACGTAAATTACAATCACGTAATTCTTCTACTAAGCCCAAAAAGCACGCTTCAGCCACCGATGAAGGTTTCAAGTACCAATGCGAGCGGTGCATCAAGGTTTTCAGTTCTGTAAACGCTTTGGAAAATCACAGAAATAATGAACACGCCGCATCGTTTTGCTGTGAAGAATGTAACCAGaCTTTGCCTTCGGCCAAAGCGTTGCTGATCCATTGCAGGGCTCACAAAAGTTTAAAACCGTACGTTTGCGATACTTGCGGGCGCAGTTACTCGCAAACTTCCCATCTGTGGCAGCACATGAGATTCCATCAAgGTATCAAACCGTTTGCCTGTCCACACGAAGGTTGTGAAGCCAGGTACACAATCCGTCCAGATTTGAAAGATCACATTCGCAAGGTTCACACTAGAGAAAGACCTTTCAAGTGCAACGTCTGCAACAAGTGCTTTTTGACAGGTTCCGTCTACTACCAACACCGTCTCATACATACCAACGACCGAAGATACGGCTGTGAGATTTGCCACAAGAGATTTTTCAGGGCTGATGCATTGAATAACCACAAAAGAATCCACACAGATGAACGGCCTTATCCTTGCTCAGTATGTGGCAGGGAATTTCGACAGAAAGGTGATAGAAACAAGCATGTGAAAACTCAGCATCCCGAATACTCATTAAATAGGATTTAG
Protein Sequence
MSYTVVILMHKIVDDRIVSTVRDEKNSRLALDMVMRTYLNPDRIRLNISNYSEEKVSLNIDDHLHIQDSLVIEALNENEMIMYERMNLNFPTLTKCQNCETNFPTKYQYQRHQCDFDVNKVVFKTCPDDEIAENITENKKKTECEICGKFFASKINLEKHQETHSAHDNICEFCAKRFVSENRLRIHKENHCKKAGDVAKFYRSDVTVWKCRKCHEVFSSAEIAVHHVEICQESGDNNENKENFIEKISTEILLQCEFCNRTYSDKNLLLMHQRKHTTAKNYECVNCLRTFDSFCTASSHWLKKCTEFSNLFYLPRLSYCEYCDRTFKSHDILYNHKTKKKHYTPKLHSRADGPQKLDEDGEVKPLIENKDIVNKLIEDVLKTLEVPVNDLDDGGEVQMQEIKVKIEPGVEDLSSSRLEQEIIEEQIKPPKKRKLQSRNSSTKPKKHASATDEGFKYQCERCIKVFSSVNALENHRNNEHAASFCCEECNQTLPSAKALLIHCRAHKSLKPYVCDTCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKVHTRERPFKCNVCNKCFLTGSVYYQHRLIHTNDRRYGCEICHKRFFRADALNNHKRIHTDERPYPCSVCGREFRQKGDRNKHVKTQHPEYSLNRI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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