Basic Information

Gene Symbol
tfap2e
Assembly
GCA_958496175.1
Location
OY292279.1:29004095-29009882[-]

Transcription Factor Domain

TF Family
AP-2
Domain
TF_AP-2 domain
PFAM
PF03299
TF Group
Basic Domians group
Description
Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 1.6e-80 3.2e-76 255.8 0.0 1 196 326 526 326 527 0.93

Sequence Information

Coding Sequence
ATGATCGAGTCATCCATGAACGGAAGCTGGATGGTTATAATTGCGTGtcttgaAAGATTAACGTCGTCTCATCATCATCAGAGTGGAACAAATTTGTCGTCACATTACAATAATAGTGGCCAAGGAGGAAATAATGGGGGTGGTGGAGGAGGCAATGGGGGCGGCGGCGGGAATGGGGGTCGTGGGGGCAGTAATAGTAGTTCAAGTGCTCAACTTGCGGCTCATCACCACATGCATCAACAGGCGCAATTGGCATCGGCCGCGGCGGCTGCAGCCGCCGCTGCCGATTTCCAGCCACCGTATTTTCCACCCCCATTTCACCATCACCCACATGCGACAGGTGCGACCCTCAATCATCACGGCTTGCAGACCAATTTAGCAGGCAATGGGGGAGGCACAAGCTCACCACCCGGTGGAGCGGTCATTGGGGGTGGAGGAGGCTCTGTTGGTGGTCCCGGAGGCAATATTGGTTCAGCGGGTGGAGGTGGCGGTGGAGGTTTGGGAGATTATCCTCCCCATATTGGGGATCCCTATGTGGCCGCACTGGCGGCTCATCACCACCACAGTGCAAGTGTCAGCCATTCAGGGCCGGTAAGTGCTTTGCACTACAACCAATTGGCTGCCCTTCGAACCCCTGGTTCCGGCGGAGGACATCATCGGGGCGGTTCTGGAGGAACAGGACTTGGGATCGAACAAGATTCCCACGTCGTGtcGGGGTTGTCACACAGTGGATTCCCATACGGGGGTGGTGGCTACAGTCTTCCCCCGGGAGCTGGATCTCGAGGACTTCACGACGATCCTCTTGCCTTACACCAAGCTCTGTCTCAAGCTGTTGATGACGGACAGAATACCGGCCTGGATGACAATAGCGGCTTCATCTCGGACTTGCCATTATTAAAAaGTATGAAGTCAGTTGGAAAGGATCATTCCGGTGGAGGATTAGGAGGAGGTCACATGACATCACCAGCCGACGTCTTTTGCTCGGTTCCTGGACGACTTAGTCTCTTGTCTTCCACTAGTAAATATAAAGTAACCGTGGCTGAGGTACAACGACGGCTTTCACCTCCTGAATGCCTAAACGCGAGTCTTCTAGGTGGCGTTTTACGAAGAGCGAAAAGCAAAAACGGCGGTCGACTACTACGtgaaaaattggagaaaatcgGGCTGAATTTACCAGCGGGTCGACGAAAAGCGGCCAATGTGACCCTATTGACATCATTGGTCGAGGGTGAAGCGATTCATTTAGCTCGGGATTTCGGTTATGTATGCGAGACCGAATTTCCCGCGCGACAAGTCGCGGAATATTTATGTCGCGGTGCGACTGGAGGCGTTTCTGGAGCCCAAGCCGAACATGAGGCACTTAGGCGTCGGGACTTATTACACGCAACCCGACATATCACTAAGGAGCTCATGGATCTCCTCAACCAAGACCGatctCCTCTGTGCAACACGCGACCACAACACTTACTTGATCCCTCGATCCAAAGACATCTTACGCACTTTTCGCTGATTTCCCACGGGTTTGGAAGTCCTGCAATTGTGGCCGCCTTGACGGCAATTCAAAACTTTCTAAACGAATCCTTAAAACATTTAGACAAATTATATCCACCATTAGACaacaaaacaacaaaattaGAAGATAAAAAGTAA
Protein Sequence
MIESSMNGSWMVIIACLERLTSSHHHQSGTNLSSHYNNSGQGGNNGGGGGGNGGGGGNGGRGGSNSSSSAQLAAHHHMHQQAQLASAAAAAAAAADFQPPYFPPPFHHHPHATGATLNHHGLQTNLAGNGGGTSSPPGGAVIGGGGGSVGGPGGNIGSAGGGGGGGLGDYPPHIGDPYVAALAAHHHHSASVSHSGPVSALHYNQLAALRTPGSGGGHHRGGSGGTGLGIEQDSHVVSGLSHSGFPYGGGGYSLPPGAGSRGLHDDPLALHQALSQAVDDGQNTGLDDNSGFISDLPLLKSMKSVGKDHSGGGLGGGHMTSPADVFCSVPGRLSLLSSTSKYKVTVAEVQRRLSPPECLNASLLGGVLRRAKSKNGGRLLREKLEKIGLNLPAGRRKAANVTLLTSLVEGEAIHLARDFGYVCETEFPARQVAEYLCRGATGGVSGAQAEHEALRRRDLLHATRHITKELMDLLNQDRSPLCNTRPQHLLDPSIQRHLTHFSLISHGFGSPAIVAALTAIQNFLNESLKHLDKLYPPLDNKTTKLEDKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00238390;
90% Identity
iTF_01060318;
80% Identity
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