Basic Information

Insect: Sipha flava
Gene Symbol: Runx1
Assembly: GCA_003268045.1
Location: NW:346929-378398[-]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 6.1e-74 1.9e-70 233.9 0.0 3 129 43 169 41 169 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	6.1e-74	1.9e-70	233.9	0.0	3	129	43	169	41	169	0.98

Sequence Information

Coding Sequence: ATGGTGGTCAAAGGGGCCCAGATGAACGTCAACGGCGGGACGGCGCAGGGCCCGGCGGCCGAAGACGGGCTGTCCGAGGCGTACGCCAAGATGACCGCGGACATACTGGCCGAAAGGTCGTTGGGTGACTTCCTGTCCGAGCACCCGGGCGAGCTGGTGCGCACCGGCAGCCCGTTCCTGGTGTGCACCGTGCTGCCCACGCACTGGAGGTCCAACAAAACGCTGCCGGTGGCGTTCAAGGTGGTCGCGCTCGGCGAGGTGCCGGACGGCACGGCCGTCACCATACGCGCGGGCAACGACGAGAACTACTGCGCGGAGCTGCGCAACTGCACCGCGCTCATGAAGAACCAGGTAGCCAAGTTCAACGATTTGCGGTTCGTCGGCCGCAGTGGCAGAGGCAAGAGTTTTACGCTGACCATAACCGTGAGCTGTTCACCCCCGCAGGTTACCACTTACAACAAAGCCATCAAAGTCACAGTAGACGGACCCAGGGAACCGCGTTCCAAAACACGACAACAGCAACAGTTTCACGCGTTCGCGTTCGGCCAACGGCCGTTCTTGTCGACTCACTTCGCTAACCCGCTGGACCCGTTGCACAGAACCGCGGATCCGTTGGCGTTTCGGATGCCGGCCATGACGAACTGTCAAAACATGGGCCAGTTCGCGCCGCACCATTCGTGGGGATACTCGCATTCCACCGCGTACTCCACGTGGCCGGGAGGGGGCGGTTGCACGAACTTCACCCCGCCCGCACTAACCGCCACCGGATTCACCGGCACCGCGGCGGCCACGACGTCGGAACTGCACACCTCGCTGACCGCTGCCGGCCACCATCACGATCTGTTCCCCAACTGCTCGGCCAACGCGCTGACCACCGTCGCCGTGATGCCATCGTTCTCGGACACCAGCGGCACGACGGCGAACAGCGGTGACCTGGAACAGCAATTGTTGCTGTCGTCATCGTCCAACTGCCACCAGCAGCAACAAGACAACAGGACCGGGTTCTCGACGGCTAGGGGTtatcagcagcagcagcagcaatcAGCAGGAAATGACCAGGTGATGGCGCCGCCGCCGTCAGACCTGCACCCGTCCACGTCGTCGGGCCCGCGGTCCACCGACTCGTCGGCGCCGGACTCGCCCACCGGGCCCGTCGGCTCCGCGGACGACATGATGGCCATCGGCCAGTCGCATGGTTACGAGCATGTGGGCGGTAGTGGTTACCACGGTGGTGGTCATCCGACCATGATACCGGCGTCCCTGCAACTGTACTCGCAGTTGTACCACGCGTCCGCGGCCGGCCACACCACCCGGCACcatcaccaccatcaccacTATCACCAACCCGGCGACGGCGACGAGCACCTAGCCACCGTAGCCCAGCGGCCCACGCAGCAGGCGGTGGCCGCGGCCGACCACTCGGCCGTGTGGAGACCTTACTGA
Protein Sequence: MVVKGAQMNVNGGTAQGPAAEDGLSEAYAKMTADILAERSLGDFLSEHPGELVRTGSPFLVCTVLPTHWRSNKTLPVAFKVVALGEVPDGTAVTIRAGNDENYCAELRNCTALMKNQVAKFNDLRFVGRSGRGKSFTLTITVSCSPPQVTTYNKAIKVTVDGPREPRSKTRQQQQFHAFAFGQRPFLSTHFANPLDPLHRTADPLAFRMPAMTNCQNMGQFAPHHSWGYSHSTAYSTWPGGGGCTNFTPPALTATGFTGTAAATTSELHTSLTAAGHHHDLFPNCSANALTTVAVMPSFSDTSGTTANSGDLEQQLLLSSSSNCHQQQQDNRTGFSTARGYQQQQQQSAGNDQVMAPPPSDLHPSTSSGPRSTDSSAPDSPTGPVGSADDMMAIGQSHGYEHVGGSGYHGGGHPTMIPASLQLYSQLYHASAAGHTTRHHHHHHHYHQPGDGDEHLATVAQRPTQQAVAAADHSAVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00340353; iTF_01499425; iTF_00468742; iTF_01346858; iTF_00135085; iTF_00972825; iTF_01167376; iTF_01032655; iTF_01305319; iTF_01328386; iTF_01303958; iTF_01304630; iTF_01350172; iTF_00018786; iTF_01037518; iTF_00134013;
90% Identity: iTF_01346858;
80% Identity: -