Basic Information

Gene Symbol
-
Assembly
GCA_949319165.1
Location
OX439233.1:7136670-7139157[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 1.8e-05 0.00097 19.7 1.6 3 23 165 185 164 185 0.97
2 11 4.4e-05 0.0024 18.5 0.2 1 23 191 213 191 213 0.96
3 11 4.5e-08 2.4e-06 27.9 1.2 1 23 219 241 219 241 0.97
4 11 1.2e-05 0.00063 20.3 0.2 1 23 247 269 247 269 0.97
5 11 0.89 48 4.9 0.9 1 19 274 292 274 296 0.82
6 11 0.00012 0.0063 17.1 0.6 1 23 402 424 402 424 0.97
7 11 5.2e-06 0.00028 21.4 0.7 1 23 430 452 430 452 0.98
8 11 0.00014 0.0074 16.9 0.2 2 23 459 480 458 480 0.96
9 11 0.00015 0.0081 16.8 1.0 1 23 486 508 486 508 0.97
10 11 0.0041 0.22 12.3 1.8 1 23 512 536 512 536 0.97
11 11 0.026 1.4 9.7 0.7 1 23 543 566 543 566 0.98

Sequence Information

Coding Sequence
ATGATTTCTACTGCCATCATGGAGTGTGCTCCAGTACATATTAATCTTGACGATAATTTGCCACAATATATTTGCAATATGTGTATTGATGATTTATCGAAGGCGCACCAATTTAGAGCAAAGTGTATACAGTCTGACATATATCTACGTAAACGTAATTCAGATTTTTCTTCTTCCACGAAAATagaagatattattttaaaagaagaaCTTGAACACGAGTTAAATATATGTGATCAAATAAAAGACAACAGTactgaatttaaattaaaagaagaAAATGAAAACTCAGAAAGAAGTTACAGAGATGATGTTGAAAATGATGAAGACAGTGATGAAAATATTAGTttacttgaaattaaaaaaaggcaaaccgatttatctattttaaaaaagaaaagatGCAAAAGAAAAATAAGTAATTCACATTCACAAAGTACAACAAGAAACCATAAGGTAGATAGAGATAAATTAAATACAGAAGTTAATTACTGTGATTCTTGCAAGATGACATTTTCAAATAGACCTAATTTACTTCGACACCTGCGAACTCACAaaggagataaaaattatagctGTAAAGTGTGTGGAAAGAGATTTGCAACACCAGCATACGTTAAATCACATAGTATAGTTCATACTCGAGAACGCagGTTTGCGTGCGATACCTGTGGAAAAACTTTCACGTTCAACAGTGATCTGACTGTTCACATGCGTAAACATTCAGGAGAAAGACCGTACGTGTGTGAAGTGTGTGCAAAGAGCTTTGTGTCATCGAGTGCATTAACAGCACATAGATTCAAGCATGGTCCAAAGAGATTTTTTTGTGTGGTCTGTAACAGAGGATTTACTTATAAACAAGAGGCAGATTCGCATTCTTTTGCTCATCGAAATGACAGGTTCATAATAATTGACGATCCTGACCACCAAACAAAAATAACTCCGTCTGTAGTAGAACTATACGGGGCTGTTGTTGAACACAAAAATGACGAAAACAGTGAAAAAGTTGCTGATACCAAAAACGACTCGATAAAATTTGAAGACAACCACATGAACACGATAGAAAAtactgataataaaataaattccacatcAATTATATACAGCAGAACTGAAAAAGAACCGTATAAAATAACTAAAGAAAACTATGACCAATATGTAGAAACGTATAAAcgtttaaaaaattcagtaaaaTCAGAAAACTTCACGTGTGATGTTTGTAATAGAATATTATCATCATTAAGCAACTTGTATCGTCATAAGTTAATACATACAGGTTTAAAACCATACGTATGTGAAATATGTAACAAAAGTTTTAAACTGCGAGCTGATTTACAAGAACACAAGAACCGACATTTGGGGATACGAAAGATTCAGTGTGAGTTTTGTCCGAAAATGTTTCCAACAAAAAGTGACTACGGAAAACACGTCTCTATTCATATGGATCATAAACCTTTTGTTTgtgatatatgtagtaaatcTTATTATAACATTTATGCTCTGAAGCAACACAGGAAAGATCATTTACATGAATTTAAGTGCAGTTACACAGGCTGTACGAAATCGTATCCTACTCAAGAGAAGTTGGATAAACATTCTAAGTTACATGATGAAACTAAAAGACGGTTTCGATGTGATTTTTGTACAAATTCTTTGGGTACAGTTAAATCTTTAATTAGGCATGTTCGGAAAGTGCATAAACAAGATGTGCAGCAAAGTGTTGTAAATAAGTCATAA
Protein Sequence
MISTAIMECAPVHINLDDNLPQYICNMCIDDLSKAHQFRAKCIQSDIYLRKRNSDFSSSTKIEDIILKEELEHELNICDQIKDNSTEFKLKEENENSERSYRDDVENDEDSDENISLLEIKKRQTDLSILKKKRCKRKISNSHSQSTTRNHKVDRDKLNTEVNYCDSCKMTFSNRPNLLRHLRTHKGDKNYSCKVCGKRFATPAYVKSHSIVHTRERRFACDTCGKTFTFNSDLTVHMRKHSGERPYVCEVCAKSFVSSSALTAHRFKHGPKRFFCVVCNRGFTYKQEADSHSFAHRNDRFIIIDDPDHQTKITPSVVELYGAVVEHKNDENSEKVADTKNDSIKFEDNHMNTIENTDNKINSTSIIYSRTEKEPYKITKENYDQYVETYKRLKNSVKSENFTCDVCNRILSSLSNLYRHKLIHTGLKPYVCEICNKSFKLRADLQEHKNRHLGIRKIQCEFCPKMFPTKSDYGKHVSIHMDHKPFVCDICSKSYYNIYALKQHRKDHLHEFKCSYTGCTKSYPTQEKLDKHSKLHDETKRRFRCDFCTNSLGTVKSLIRHVRKVHKQDVQQSVVNKS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01343346;
90% Identity
iTF_01343346;
80% Identity
-