Basic Information

Gene Symbol
-
Assembly
GCA_961205875.1
Location
OY540816.1:13396108-13400466[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.13 6.9 7.5 1.9 1 23 298 320 298 320 0.93
2 13 0.026 1.4 9.7 1.2 1 21 325 345 325 349 0.92
3 13 0.00071 0.038 14.6 0.4 3 23 378 399 376 399 0.93
4 13 4.3e-05 0.0023 18.4 0.1 1 23 405 427 405 427 0.96
5 13 0.0054 0.29 11.8 0.5 1 23 436 459 436 459 0.96
6 13 1.9e-06 0.0001 22.7 4.6 1 23 465 487 465 487 0.98
7 13 0.00021 0.011 16.3 0.3 1 23 493 515 493 515 0.98
8 13 0.00013 0.0072 16.9 3.5 1 23 521 543 521 543 0.97
9 13 2.6e-08 1.4e-06 28.5 1.9 1 23 549 571 549 571 0.99
10 13 2.7e-05 0.0014 19.1 4.8 1 23 577 599 577 599 0.97
11 13 0.91 49 4.8 4.5 3 23 607 627 605 627 0.95
12 13 7.8e-05 0.0042 17.6 3.0 1 23 633 655 633 655 0.98
13 13 4.5e-06 0.00024 21.5 1.0 1 23 661 683 661 683 0.97

Sequence Information

Coding Sequence
ATGGAAGTACTTTTATATCAATCTACAATATGTCGTTTATGTGCCGAAGAAAATTCAAATGgactttatatattttcaaatgacgattctgaaaataatttatgtaataatgttaataaataccTACCAATAAAGATTTCAAATGATGAGAAATTCCCATGTACCATTTGTCCAGGATGTAATATTCAGTTGGAAGCAACAATACAATTTTTGGATCTGGTAACTGCTGGTCAAGTACGACTTAGacagttattaaaaaatcaacaagATGAAATGCGAAAACTACAACGTGACACTGATAATGGAAATATCAGTCCAACTACAGAAAATTGCACGGTTCAAACCATTATTGTTAATGATGGAAACACTGAAGGAGACACAGAAGTTGTAGTACAGTTAATTCAAGACGGACCATTATATCCACCTGATCATGaacaatgtttaaaaattgAAGGCTTAGAAAAGCCACGTCGTAAACGAGGACGTCCACCTAAAGCTTCAGTTTTTTCTgaagaaaaaattgaaattacagAATCAGTTGTAGAATCTTCTAAAGAACAGAAGAGTCAAAATGAAGATGATGAAGAGTTTGATGCAGATGGGAGGAAAAAACGCAGAAGAAAAGTTCCTACTAGATATAAAGAAGCAGTACAAGGCAAGGAGTTAGAACGAATGTTCCGTGAAGAAGGTGTTATAGATGGTAATGAATCTTGTGGTGATGATGATGATAGTCCTACTGTAAAAATAGAAGAAACTATCGAACCAATTAAACATGAACCAGAAGTAATAGGTCATTTAGAATCAAAAGAAGGTCGAGATCTTGGAGAATTAATTGTTATAACAAAATCTCGAGGTCGTGGACGACCGAAAACTTATAAACGAAGGTTTCGATATACTTGTGAAATATGTGGACGTGGATTTCTGCATTATGgaagatttaaattacataaatcagtacataaaaatgttaaatacgaGTGCACTGATTGTTCAGACCGGTTTGATTCAAAGACAAAACTACAAGAACACCAAACTGAATCAAAACATGCTGGTGAAGTAGTTGTAGAAGGTCTTGAAAACgagGTGgtgaaagaagaagaaaatgatacagcagaaaataaaaaaatcgcctGTGAACAATGTCATAAAACATTTGTTACAAAGCAGAGTTGGGAAGTGCATGTGAAAGCGATTCATGAAGGCAAAAAGCCATTTGCTTGTGAACAGTGTGGTAAAACTTTTGCATATGCAGCAAGTTTGAAAGGACACTTGGCTTCACATGatGTTAAAGGAACAGAAAAGTTATTTCCATGTGATGAATGTAATAAAGTATTAAACCATCCTAGTAGTGTTGTCTATCACAAACAGTCCGAACACAACAATGGTCGACGCTTTGTCTGTAACAAATGTAACAAGAGTTTCAAACATAAACAGTTACTCCAGCGGCATCAGCTCGTGCATACAGACAAACGTCCGTATAACTGTAACGAATGTGGAGCTCAATTCAAAGCTCGGGCAAATCTTCTTAACCATAAACTGACACATTCTGGTGTGAAGAAACATTATTGTGATATATGCGGCCAGCAGTTTGCACACAAGACTTCACTAACATTGCATTATCGATGGCACCAAGGACACAAACCATTCCGTTGTTCTTTTTGTGATAAAACATTTTCACAAAAAgGCAATCTACAGGAACACATGCGCATCCACACCGGAGAAAAACCGTTCTGCTGCAACGTGTGCGGTAGACGCTTCACGACATCGTCGCAGTATCGGCTCCATGTGAAGCGGCACACAGGGGAACGTCCTTGGGCGTGTGAGATATGCGACAAGCGGTTCCTACACAAAGACACTTGGAAGTGCCACACTCGACGTCATCTAGGTCAGCGCCCATTCCAGTGTACGTCGTGCAAACGTGCTTTCACTGAACATTGGGCTCTCAAAAAACATATGCGGCTGCATACtggtgaGAAGCCATATGTTTGTGATATATGTGATAGAGCATTCGCAGATTGtagtaatttatctaaacacaaAAAGGCTCATCTGACAACAACGGTAAAGAATGCTATTTGGGAAAATTTGGCAGCATCGGCTGCTTCCACCGTTAATACAGCAGCTACTGGAACATTGTTCAAAGCAGATGaagGTTCCAATGatgaattaaaacaaatattttatgtatcttACCAAGACTTAAATGAAACAACTGATTCACAGACGTTACAAATAGAAACAGATGTTAATAATAAGTTGCAGATTGTAgaaaattgtaatgaaaaatcACTTATACCAGAGCAATTGAATTTAACTGTAACTGATATGCATTTACCACCTGGACCAATACAGGTAACCGATGAAGAAGGAAATCctataaatattacaacacaAGATGGAAGTCAGTTGAGAGTGACTACTTATGATGGTGAACATTTACAAGTTACAACTTTAGATGGTACTACGTTACCGATAGAACTAAATGTACAAAATGGTAACGCTTATATTAGAAAAGAAATTTTATCTACGGATGAAAATACTACAGAAGATTTAGTTACAGCAGATCCTCTTGATTTTAGTGATTTAacaaaaGTGAAAGATATCGAATCACTTACTGAAGAAGCATTGAATGAAGAACATACGATTGAATTTCTTACACAAGACGGACGGAAAATGCGATTAGTTACATATGGCGAAGGATCAGAATCAGAATATTTaacaattgtttaa
Protein Sequence
MEVLLYQSTICRLCAEENSNGLYIFSNDDSENNLCNNVNKYLPIKISNDEKFPCTICPGCNIQLEATIQFLDLVTAGQVRLRQLLKNQQDEMRKLQRDTDNGNISPTTENCTVQTIIVNDGNTEGDTEVVVQLIQDGPLYPPDHEQCLKIEGLEKPRRKRGRPPKASVFSEEKIEITESVVESSKEQKSQNEDDEEFDADGRKKRRRKVPTRYKEAVQGKELERMFREEGVIDGNESCGDDDDSPTVKIEETIEPIKHEPEVIGHLESKEGRDLGELIVITKSRGRGRPKTYKRRFRYTCEICGRGFLHYGRFKLHKSVHKNVKYECTDCSDRFDSKTKLQEHQTESKHAGEVVVEGLENEVVKEEENDTAENKKIACEQCHKTFVTKQSWEVHVKAIHEGKKPFACEQCGKTFAYAASLKGHLASHDVKGTEKLFPCDECNKVLNHPSSVVYHKQSEHNNGRRFVCNKCNKSFKHKQLLQRHQLVHTDKRPYNCNECGAQFKARANLLNHKLTHSGVKKHYCDICGQQFAHKTSLTLHYRWHQGHKPFRCSFCDKTFSQKGNLQEHMRIHTGEKPFCCNVCGRRFTTSSQYRLHVKRHTGERPWACEICDKRFLHKDTWKCHTRRHLGQRPFQCTSCKRAFTEHWALKKHMRLHTGEKPYVCDICDRAFADCSNLSKHKKAHLTTTVKNAIWENLAASAASTVNTAATGTLFKADEGSNDELKQIFYVSYQDLNETTDSQTLQIETDVNNKLQIVENCNEKSLIPEQLNLTVTDMHLPPGPIQVTDEEGNPINITTQDGSQLRVTTYDGEHLQVTTLDGTTLPIELNVQNGNAYIRKEILSTDENTTEDLVTADPLDFSDLTKVKDIESLTEEALNEEHTIEFLTQDGRKMRLVTYGEGSESEYLTIV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01344274;
90% Identity
iTF_01344274;
80% Identity
-