Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0077 0.53 11.2 1.0 2 23 146 167 145 167 0.95

2 6 0.00046 0.032 15.1 0.5 1 23 171 194 171 194 0.94

3 6 0.0067 0.46 11.4 1.2 3 22 202 221 201 221 0.95

4 6 0.00053 0.037 14.9 1.6 1 23 228 251 228 251 0.92

5 6 0.00096 0.066 14.1 3.5 1 23 257 280 257 280 0.95

6 6 0.019 1.3 10.0 5.0 2 23 286 307 285 307 0.95

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0077	0.53	11.2	1.0	2	23	146	167	145	167	0.95
2	6	0.00046	0.032	15.1	0.5	1	23	171	194	171	194	0.94
3	6	0.0067	0.46	11.4	1.2	3	22	202	221	201	221	0.95
4	6	0.00053	0.037	14.9	1.6	1	23	228	251	228	251	0.92
5	6	0.00096	0.066	14.1	3.5	1	23	257	280	257	280	0.95
6	6	0.019	1.3	10.0	5.0	2	23	286	307	285	307	0.95

Coding Sequence: ATGTACTTTGTACATTTTGGACAAAGATACGAGAAGATTTCAAAGAAAAATTTTCTTCTTCTAGACATATCTCAGTACGACCCTGTGAGGAGAAATGCCGAAATCATCATAAAGTACACGACCGCTTATCCCTTCAGGGCGAAGGTTACGTCTATACTATGCGTCTACTGCGGAGACTTGCACGATGATCCAACACTATTCAGAAGACATGTCGATGACGAGCACAAAACCTTCAATGTCAGAATGGCATTCATTACCCTTCCTAAAACAGAGTTGGTAAAAGTAGACTTATGCGATCTGAAATGCAGGATCTGCCACGGAAACTTACAAGATCTACAATTCGCGGCGGAACATTTGAAATCAAACCATTACAAGGCATTGAAAACGGACACTCAGCTCGGCTTGATGCCGTATCTTTTAGAGAAGGCTAGATGGAAGTGTGCGATATGTGAGAAGAGTCTTCCATCCTTTTTACATTTAAACAAACACACGGTCAGGCATTTCTTGAGCTACATCTGCCACACGTGCGGCAGCACATACATCTCGTCCGCTGGCCTCATGAAGCACGTTCAGGCTAAACACGAAAATGAGTTTAAGGCTAACTGTAAACGCTGTCACAAGTCCTTCCCGTCGTTGGAGGCTAAAGCTCAGCATCAGAGAACGGAGAAGCGGTGCATGCTACATTGCTGCACGGAATGTCCCGAACGCTTCCCGAACTGGGAGTTAAAGCAGCGCCACATGGAGGACATACACAGAATGACAAAGACTTACTACTGTTCAGATTGCAACCTGACGTTTTCCAAACGCAAGTCGTTTTACGCTCACTTCAAACTGAGTCATACACAGGATTGTTTAATTTGTACACACTGCGGTTTGAAATTTACATGTAATTCAAAGTTGAGCAAACATTTAGGAAAACACAAGTTAGGACGGTGA
Protein Sequence: MYFVHFGQRYEKISKKNFLLLDISQYDPVRRNAEIIIKYTTAYPFRAKVTSILCVYCGDLHDDPTLFRRHVDDEHKTFNVRMAFITLPKTELVKVDLCDLKCRICHGNLQDLQFAAEHLKSNHYKALKTDTQLGLMPYLLEKARWKCAICEKSLPSFLHLNKHTVRHFLSYICHTCGSTYISSAGLMKHVQAKHENEFKANCKRCHKSFPSLEAKAQHQRTEKRCMLHCCTECPERFPNWELKQRHMEDIHRMTKTYYCSDCNLTFSKRKSFYAHFKLSHTQDCLICTHCGLKFTCNSKLSKHLGKHKLGR

Sequence clustering based on sequence similarity using MMseqs2