Basic Information

Gene Symbol
ZNF296
Assembly
GCA_029286605.1
Location
JAGSMR010000112.1:385284-398842[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.0036 0.35 12.0 0.4 1 23 278 301 278 301 0.96
2 11 2.3 2.2e+02 3.2 1.6 1 19 308 326 308 332 0.81
3 11 0.0015 0.14 13.2 0.6 1 23 335 358 335 358 0.95
4 11 0.026 2.4 9.3 0.9 1 23 362 385 362 385 0.95
5 11 5.5e-06 0.00052 20.9 4.5 3 23 390 410 388 411 0.94
6 11 0.076 7.2 7.9 3.3 3 23 416 437 415 437 0.96
7 11 0.0013 0.12 13.4 0.2 2 22 451 471 450 475 0.92
8 11 2.3e-06 0.00022 22.1 0.4 2 23 484 506 483 506 0.95
9 11 0.0025 0.24 12.5 1.3 1 23 512 535 512 535 0.96
10 11 2e-05 0.0019 19.1 0.4 3 23 546 566 545 566 0.98
11 11 0.023 2.2 9.5 1.3 1 23 572 595 572 595 0.97

Sequence Information

Coding Sequence
ATGAACAAAGTTAAATTTGAACTGGGATTGGATTATTCTGATATATGGTTGTGCTGGGAATGCATAAGTATATTACGAAGATCATTGAAGTTCCAGGAACAAATTAATCAAGCACAAATTCTACTGCAGCAGACTGGTTATCCTTTGaataaaaataaagaattcacCTTATCAACATTGGGTGTAGTAACGAAGAAAAATTTTGATACTATTTATGAAAGCAATTGCGAAGAGACTGATCATGAATTACAATACAAAATTGAAGGAGATACCAATGAAATTGTGGAAGAGAatagaaaagtaatttatattgaCAAAAATAAAGTGACAGACGATAATTATGATACAGTGTATGAAAGCGATTTTCAAGAGACTGATATTAACGCGGAATACGAAACAGAAGAAGAAGCCATCGTAAAAGAAAAAGCAAATAAAGAAGGAGTTGATTTTGACAAACTTAAAGTAAGGAACAACAGTGCGCGATACAAAATTGATGATGATGCTTCgaaatttgaaaatgaaattaaaagagagatatttattgacaaaattaaaacggACCATAGTGATGACTCAGAAgcgaatatgaaaaatattgatatagacATCTACGATAGTATAAAGCCTAAAGGTGAATATGGAAAAGAGAAAGAGAAACTGATTTCGAAGACTATAAGACAACACAACTACAGAAAAAAAGCGACCATAACTAAGAAtaacatagatatagataatatagaCAATTATTTCACAAAATGCACAGTGAATGTAAAGATTATAGAAGATATATTGGAAAGGCGAAAGAAATTAACACACAAGAAGAGTCCACGGTTCGTctgtaaaatttgtaaaattggaTTTCAACAGATTATCGATATGAAACGACATCAGCTTATAAAACATCCACCGCCTACGGGACCGTACAAGTGCACCGAATGCCAGCACTACACAAATATCCCGACGATGCTTGAACTGCACGAGCACTGGCGGAGTCATACCGTGTACGTATGCAACCGTTGCCCGGAAGTGTGCAAGTCGCGACCGGAAATGAACAGGCACCTCGTACGAGTGCACCAGTTCACGTACCGGTGTAATTATTGCGAGGGCGTCTATGGTTCATTCCGCGAGTTCATCCGTCACTACAAGGATCTGCATCAGAAGATGATATGCGACCACTGCGGGAAGACGTTTGTTAAGAAGCGCTCATTGGAGACGCACATcaaACGCCACCACCTACCGCCAATCTGCTACAAATGCGGCCTCACGTGCAGAAGCGTCGACGCCCTGCATTCCCACAGCAGGAGACTCCACCCGGAGTTATATTACGACCTGAGCAAGACGGAGCTCTCGTACTGCGTCGAGTGCGACAAGCAGTTCGCCAGCGTGTACGCATACAGGAGGCACCTGAACACCGCTTATATACACCGGCCGCCGAAACCGGTTAGCGTCCCTTGCCCCGAGTGTGGCAAAGTGTTTTCGAGGAAGAACTACATGAATAACCATTACAAATTGTTCCACGCGAAGAAATCCCGACACTACTGCGAGCTCTGCGACAAGTACTACGTCACTGGGTACGCATTGAGAAACCATAGACTCCGCGTCCACGAGAAAACGTTCCCGCCTAAAAACAAGATATGTGAAATATGCGGCCGTGGGTTTAGTACAAACAGGGTCTTGTTAAACCACACACGCACCCACACAGGTGAGAGGCCGTACAAATGCTCACAATGCCCGGCGGCCTTTGCACAGCTCTGCGCTAAAAAATCACACGAGCGCTCCCAGCACAAGATATTCTGA
Protein Sequence
MNKVKFELGLDYSDIWLCWECISILRRSLKFQEQINQAQILLQQTGYPLNKNKEFTLSTLGVVTKKNFDTIYESNCEETDHELQYKIEGDTNEIVEENRKVIYIDKNKVTDDNYDTVYESDFQETDINAEYETEEEAIVKEKANKEGVDFDKLKVRNNSARYKIDDDASKFENEIKREIFIDKIKTDHSDDSEANMKNIDIDIYDSIKPKGEYGKEKEKLISKTIRQHNYRKKATITKNNIDIDNIDNYFTKCTVNVKIIEDILERRKKLTHKKSPRFVCKICKIGFQQIIDMKRHQLIKHPPPTGPYKCTECQHYTNIPTMLELHEHWRSHTVYVCNRCPEVCKSRPEMNRHLVRVHQFTYRCNYCEGVYGSFREFIRHYKDLHQKMICDHCGKTFVKKRSLETHIKRHHLPPICYKCGLTCRSVDALHSHSRRLHPELYYDLSKTELSYCVECDKQFASVYAYRRHLNTAYIHRPPKPVSVPCPECGKVFSRKNYMNNHYKLFHAKKSRHYCELCDKYYVTGYALRNHRLRVHEKTFPPKNKICEICGRGFSTNRVLLNHTRTHTGERPYKCSQCPAAFAQLCAKKSHERSQHKIF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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