Basic Information

Insect: Sericinus montela
Gene Symbol: -
Assembly: GCA_029286605.1
Location: JAGSMR010000046.1:1173575-1184556[-]

Transcription Factor Domain

TF Family: MH1
Domain: MH1 domain
PFAM: PF03165
TF Group: Unclassified Structure
Description: The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 28 0.0015 8.2 7.3 0.0 55 80 288 313 258 322 0.77

2 28 0.0003 1.6 9.5 0.1 29 81 361 409 353 418 0.74

3 28 0.0077 42 5.0 0.2 57 78 421 442 408 444 0.78

4 28 0.0027 15 6.5 0.0 55 80 472 497 458 506 0.76

5 28 0.0024 13 6.6 0.6 31 76 522 563 515 589 0.61

6 28 0.0029 16 6.4 0.1 59 82 591 614 584 621 0.79

7 28 0.016 85 4.0 1.3 58 79 633 656 611 666 0.57

8 28 0.0026 14 6.5 0.1 58 82 667 691 659 698 0.78

9 28 0.0028 15 6.4 0.2 58 81 699 722 689 732 0.80

10 28 0.0021 12 6.8 0.1 58 82 735 759 723 767 0.78

11 28 0.0027 15 6.5 0.2 58 82 767 791 757 798 0.79

12 28 0.0027 15 6.4 0.1 58 82 799 823 792 830 0.79

13 28 0.0026 14 6.5 0.1 58 82 831 855 823 862 0.78

14 28 0.0035 19 6.1 0.1 59 80 864 885 857 894 0.80

15 28 0.00096 5.3 7.9 0.1 48 82 903 937 885 945 0.73

16 28 0.00095 5.2 7.9 0.1 50 80 973 1003 953 1011 0.70

17 28 0.0025 14 6.6 0.1 58 80 1115 1137 1101 1146 0.79

18 28 0.001 5.7 7.8 0.2 51 82 1148 1179 1135 1186 0.71

19 28 0.0029 16 6.4 0.1 59 82 1188 1211 1181 1218 0.79

20 28 0.068 3.7e+02 2.0 0.1 58 80 1219 1241 1212 1249 0.80

21 28 0.022 1.2e+02 3.5 0.1 58 80 1283 1305 1268 1313 0.80

22 28 0.0041 23 5.9 0.0 57 82 1474 1500 1464 1507 0.79

23 28 0.0023 13 6.7 0.1 58 81 1579 1602 1564 1611 0.79

24 28 0.0092 50 4.8 0.1 58 82 1711 1735 1694 1744 0.81

25 28 0.0035 19 6.1 0.1 59 82 1784 1807 1774 1815 0.81

26 28 0.16 8.7e+02 0.8 0.1 58 73 1816 1831 1809 1846 0.74

27 28 0.78 4.3e+03 -1.4 0.0 55 71 1847 1864 1828 1879 0.77

28 28 0.015 83 4.1 0.1 59 76 1887 1904 1874 1912 0.80

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	28	0.0015	8.2	7.3	0.0	55	80	288	313	258	322	0.77
2	28	0.0003	1.6	9.5	0.1	29	81	361	409	353	418	0.74
3	28	0.0077	42	5.0	0.2	57	78	421	442	408	444	0.78
4	28	0.0027	15	6.5	0.0	55	80	472	497	458	506	0.76
5	28	0.0024	13	6.6	0.6	31	76	522	563	515	589	0.61
6	28	0.0029	16	6.4	0.1	59	82	591	614	584	621	0.79
7	28	0.016	85	4.0	1.3	58	79	633	656	611	666	0.57
8	28	0.0026	14	6.5	0.1	58	82	667	691	659	698	0.78
9	28	0.0028	15	6.4	0.2	58	81	699	722	689	732	0.80
10	28	0.0021	12	6.8	0.1	58	82	735	759	723	767	0.78
11	28	0.0027	15	6.5	0.2	58	82	767	791	757	798	0.79
12	28	0.0027	15	6.4	0.1	58	82	799	823	792	830	0.79
13	28	0.0026	14	6.5	0.1	58	82	831	855	823	862	0.78
14	28	0.0035	19	6.1	0.1	59	80	864	885	857	894	0.80
15	28	0.00096	5.3	7.9	0.1	48	82	903	937	885	945	0.73
16	28	0.00095	5.2	7.9	0.1	50	80	973	1003	953	1011	0.70
17	28	0.0025	14	6.6	0.1	58	80	1115	1137	1101	1146	0.79
18	28	0.001	5.7	7.8	0.2	51	82	1148	1179	1135	1186	0.71
19	28	0.0029	16	6.4	0.1	59	82	1188	1211	1181	1218	0.79
20	28	0.068	3.7e+02	2.0	0.1	58	80	1219	1241	1212	1249	0.80
21	28	0.022	1.2e+02	3.5	0.1	58	80	1283	1305	1268	1313	0.80
22	28	0.0041	23	5.9	0.0	57	82	1474	1500	1464	1507	0.79
23	28	0.0023	13	6.7	0.1	58	81	1579	1602	1564	1611	0.79
24	28	0.0092	50	4.8	0.1	58	82	1711	1735	1694	1744	0.81
25	28	0.0035	19	6.1	0.1	59	82	1784	1807	1774	1815	0.81
26	28	0.16	8.7e+02	0.8	0.1	58	73	1816	1831	1809	1846	0.74
27	28	0.78	4.3e+03	-1.4	0.0	55	71	1847	1864	1828	1879	0.77
28	28	0.015	83	4.1	0.1	59	76	1887	1904	1874	1912	0.80

Sequence Information

Coding Sequence: ATGGTCGATCCAACCCCGAAAAACGTTAAATCAGTGAAAAGTAGATTAGAtacaataaatcaaaatgaAGAATCCAGTCACAAAAGATCATCCACTATGAACAAAGTACAGTCGCACTTTCTGGTTCCATCGGAGAAGTTGGACAAAGTTACAAGACGTGTCATCGCGCCATACGCTCAGATCGAGAGGAAAGGCCTGAAGGATGACGATGCCAAACCGGGAACGTACTTAGATATTAATAGGTTCAACGTATTCTTAGAAGATAGCGTGGATCTGGATTCACTGTTGTATGAGACCGCGATGGTTCTTAAAACTGTCACAAATAGTTCAGGTGTATTTGTTTATACCGTAGACAAGATTAGAAATGAAATAGTTCTGATGACGCAAAACACGAAGAACCCAGAGCGCCACGAGGTGAATATACCCATAGAAGAAGGCAAGATAGCAGCGGCCCACGCGGCAGCTACAAAGCAGTATCTCCTTCTAGAAGATGTGCAGAAGGATCGGCGGTTTTCAGAGGGCCTCAAATGGGTGGACGCCAAGGTTGCTCTGTGTATGCCTGTTGTTAAGCCGGATGGCGACTGCTATGCTATCCTGGAACTATACAGGACCTACAGTGAACCGTACGATGATAACGTCGTGTACACAGCCGTGAGCGTCTCGTGCTGGGCGGGCGCGGCGGTGCACCAGGCGCAGGCGCGAATCACTCTTCAGAGGAGCACGCACCTCAACATGGAGCTGAGAGCTTTGCTGCAGAAGTATTTCTGCGACCTCGCTTCCATAGACACCATGCTCACTGATATGCtgGCAACAGTTAAGGTGctcctctgtctctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctctctctctctctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGCTCCTctgtctctgtctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGtgctcctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctGTGctcctctgtctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctctctctctctctctctctctctctctctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCACGGTGctcctctgtctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCTGAGCGCCAGTTCCGCTGGCTCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgccTCGCCGCGCTGGTGGCCGAGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCGCCTGCTCAAGGTGCTCCTCTGTCTCTCTCTTCTCTGCGCGCCTCGCTGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGTCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGCTCCTctgtctctgtctctctcttcTCTGCGCGCCTCGCTGCGCTGGTGGCCGAGCCAGTTCCGCTGGCTCGACCTCGCGCACCGCCGCCTGCTCAAGGTGCTCCTCTGTCTCTCTCTTCTCTGCGCGCCTGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGTCTGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctcttctGCGCGCCTCGCCGCGCTGGTGGCCGAGCCAGTTCCGCTGGCTCGACCTCGCGCACCGCCGCCTGCCCAAGGTgccctctgtctctctctctctgcgcgcCTCGCTGCGCTGGTGGCCGAGCCAGTTCCGCTGGCTCGACCTCGCGCACCGCCGCCGCCTGCTCAAGGTgccctctgtctctctctctctgcgcgcCTCGCTGCGCTGGTGGCCGAGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCTGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCGCCTGCTCAAGGTGCTCCTCTGTCTCTCTCTTCTCTCTCTGCGCGCCTGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGCCCTctgtctctgtctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTgccctctgtctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGTCTGACCTCGCGCACCGCCGCCGCCTGCTCAAGGTgccctctgtctctctctctctgcgccTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCTGCTCAAGGTgccctctgtctctctctctcttctctGCGCGCCTCGCTGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCGCCTGCTCAAGGTGCCCtccgtctctctctctctctctctctctctcttctgcGCGCCTCGCCGCGCTGATGGCCGAGCGCCAGTTCCGCTGGCCCGACCTCGCGCACCGCCGCCGCCTGCTCAAGGTgctcctctctctctcttctctCTCTGCGCGCCTGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCGCCTGCCCAAGGTGctcctctgtctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCGCACCGCCGCCTGCTCAAGGTGctcctctgtctctctctctctctctctctgcgcgcCTCGCCGCGCTGGTGGCCGAGCGCCGTTCCGCTGGCCTGACCTCGCGCGCACCGCCGCCCGCTCAAGGTgccctctgtctctctctctcttctctCTCTGCGCGCCTGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGACCTCGCGCACCGCCGCCTGCTCAAGGTgccctctgtctctctctctctcttctgcGCGCCTCGCCGCGCTGGTGGCCGAGCGCCAGTTCCGCTGGCCTGA
Protein Sequence: MVDPTPKNVKSVKSRLDTINQNEESSHKRSSTMNKVQSHFLVPSEKLDKVTRRVIAPYAQIERKGLKDDDAKPGTYLDINRFNVFLEDSVDLDSLLYETAMVLKTVTNSSGVFVYTVDKIRNEIVLMTQNTKNPERHEVNIPIEEGKIAAAHAAATKQYLLLEDVQKDRRFSEGLKWVDAKVALCMPVVKPDGDCYAILELYRTYSEPYDDNVVYTAVSVSCWAGAAVHQAQARITLQRSTHLNMELRALLQKYFCDLASIDTMLTDMLATVKVLLCLSLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSLSLSLSLSLSLSLRASPRWWPSASSAGPTSRTAACSSSAGPTSRTAACSRCSSVSVSLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLFPLARPRAPPPAQGAPLSLSLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLSLSLSLRASPRWWPSASSAGPTSRTAACSRCSSVSLSLSLSLSARLAALVAERQFRWPDLAHRRLLKFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKVLLCAPLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSLSLSLSLSLSLSLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSLRASPRWWPSASSAGPTSRTAACSRCSSVSLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLCAPLSLSLCAPRRAGGRAPVPLARPRAPPPAQGAPLSLSLSLCAPRRAGGRAPVPLARPRAPPPAQGAPLSLSLCAPRRAGGRAPVPLARPRAPPPAHGAPLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSLSLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSARLAALVAERQFRWLDLAHRRLLKVLLCLSLSAPRRAGGRASSAGPTSRTAAACSRCSSVSLFSARLAALVAERQFRWSDLAHRRLLKVLLCLCLSLLCAPRCAGGRASSAGSTSRTAACSRCSSVSLFSARLPRWWPSASSAGLTSRTAACSRCSSVSLSSARLAALVAEPVPLARPRAPPPAQGALCLSLSARLAALVAEPVPLARPRAPPPPAQGALCLSLSARLAALVAEPVPLARPRAPPPPAQGAPLSLSLCAPRRAGGRALFRWPDLAHRRRLLKVLLCLSLLSLRACRAGGRAPVPLARPRAPPPAQGALCLCLSLSLCAPRRAGGRAPVPLARPRAPPPAQGALCLSLSLSARLAALVAERQFRWPDLAHRRLLKVLLCLSLSLCAPRRAGGRAPVPLARPRAPPPAQGAPLSLSLSLRASPRWWPSASSAGLTSRTAAACSRCPLSLSLCASPRWWPSASSAGPTSRTAACSRCPLSLSLFSARLAALVAERQFRWPDLAHRRRLLKVPSVSLSLSLSLFCAPRRADGRAPVPLARPRAPPPPAQGAPLSLFSLCAPAALVAERQFRWPDLAHRRRLPKVLLCLSLSARLAALVAERQFRWPDLARTAACSRCSSVSLSLSLCAPRRAGGRAPFRWPDLARTAARSRCPLSLSLFSLCAPAALVAERQFRWPDLAHRRLLKVPSVSLSLFCAPRRAGGRAPVPLA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -