Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.027 6.7 9.6 0.1 8 22 113 127 105 131 0.82

2 7 4e-05 0.0097 18.6 0.5 1 23 171 193 171 193 0.98

3 7 0.0084 2.1 11.3 0.5 2 22 202 222 201 226 0.90

4 7 1.4e-05 0.0035 20.0 0.4 1 23 234 257 234 257 0.92

5 7 0.0018 0.43 13.4 5.2 1 23 263 286 263 286 0.96

6 7 0.0011 0.26 14.1 2.2 3 21 295 313 293 316 0.87

7 7 0.34 83 6.2 3.7 1 23 322 345 322 345 0.93

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.027	6.7	9.6	0.1	8	22	113	127	105	131	0.82
2	7	4e-05	0.0097	18.6	0.5	1	23	171	193	171	193	0.98
3	7	0.0084	2.1	11.3	0.5	2	22	202	222	201	226	0.90
4	7	1.4e-05	0.0035	20.0	0.4	1	23	234	257	234	257	0.92
5	7	0.0018	0.43	13.4	5.2	1	23	263	286	263	286	0.96
6	7	0.0011	0.26	14.1	2.2	3	21	295	313	293	316	0.87
7	7	0.34	83	6.2	3.7	1	23	322	345	322	345	0.93

Coding Sequence: ATGTCTAACGACACTGCCCCGCACACGCTGGAGGCATGCCCAGCCTGGTCGGCTGAGCGCGTGCAGCTTTGCGCGGTGGTGGGTCCCGACCTGTTCCTGCCAGCCGTAGTTAAGGCTATGGTGATGAGCAGGCAGGCTTTGGACGCGGTTCTCTCCTTCTGCGAGACCATCATGACGCAGAAGGAGGCGGCGGAGAGGGCAAGGGAAGCGGACCCGCTTTCTGACGTCATCCGCCGGAGGCGCGCTGGGAGAAGGAGGCGTGGTTGCCCTCCGGTGAGGCCTGGCCTCAACCTGGACCCGGTGAGACCTGGACCCGGCTGCGGTAGAACCGCTACAATATCCTTTACGACGACGTCAAACCTTCAGAAGCATGTGAAAACGAGCTCGAAGCATCAAATACAGTTGAAACTttgGAAACTGAAAGACACCCTACCCGACGCGTCATCCAGCGTAGAGAAACACATGCGCGCTGAACAGATAGCGCGCTCGGTGAACAACGCGCGCATGCAGTATCCGTGCGCGCAGTGCGGACGCAGTTTCCAGTGGCGGGGTAATCTGCGCAGACATCTCAAAAGCCACCGCGCCAGGGCGAACGGGGAGTTAGTTTGCGAGCCTTGCAACAGAACCTTCTCCTCTATAGCCACGTACAAGCAACACATGAAGATTAGCAAGAAACACGTCACCGAGAGCGATTTCAAgTACATGTGCAGCGACTGCGGCAAACGGTTCGCGAACAAGACTCGCCTTAAAGATCACGTGGACTGGGACCACCTCAAGAACTACGTCCACACGTGTAGCACTTGCCAAAAGGTATTCAAGAGTCATACATCTCTGTACTTACACAAGCAGGTGGTCCACAAGAAGAACAGCCCGGAGCACCTCTGCGATCACTGCGGCAAACACTTCCCGaatCGCGCGAAGCTCCGCGGTCACGTGGTGGCGCTCCACTCGGGCTCCTCGCCGTTCGCGTGCCCCCGCTGCCCGGCGCGCTTCAGCTGGCGATCATGTTTGTCGAGGCACTGTAGGCGGGTCCATCGGCAGGATGGGACGTGA
Protein Sequence: MSNDTAPHTLEACPAWSAERVQLCAVVGPDLFLPAVVKAMVMSRQALDAVLSFCETIMTQKEAAERAREADPLSDVIRRRRAGRRRRGCPPVRPGLNLDPVRPGPGCGRTATISFTTTSNLQKHVKTSSKHQIQLKLWKLKDTLPDASSSVEKHMRAEQIARSVNNARMQYPCAQCGRSFQWRGNLRRHLKSHRARANGELVCEPCNRTFSSIATYKQHMKISKKHVTESDFKYMCSDCGKRFANKTRLKDHVDWDHLKNYVHTCSTCQKVFKSHTSLYLHKQVVHKKNSPEHLCDHCGKHFPNRAKLRGHVVALHSGSSPFACPRCPARFSWRSCLSRHCRRVHRQDGT

Sequence clustering based on sequence similarity using MMseqs2