Basic Information

Gene Symbol
topi
Assembly
GCA_963935595.1
Location
OZ012554.1:30515685-30540725[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0013 0.32 13.6 0.8 1 23 279 301 279 301 0.98
2 12 0.00021 0.054 16.1 0.9 2 23 309 330 308 330 0.93
3 12 0.069 18 8.2 1.4 1 23 334 356 334 356 0.97
4 12 0.0011 0.28 13.8 1.2 1 23 361 384 361 384 0.98
5 12 0.00059 0.15 14.7 0.1 1 23 388 411 388 411 0.95
6 12 0.013 3.2 10.5 0.1 3 21 430 448 429 453 0.92
7 12 0.00064 0.16 14.5 1.0 3 23 463 484 463 484 0.98
8 12 4 1e+03 2.6 0.2 3 23 505 526 504 526 0.94
9 12 8.8e-06 0.0023 20.4 0.5 1 23 537 559 537 559 0.99
10 12 4.4e-05 0.011 18.2 0.9 1 23 565 587 565 587 0.97
11 12 0.00029 0.074 15.6 1.4 1 23 593 615 593 615 0.98
12 12 5e-05 0.013 18.0 0.2 1 23 621 644 621 644 0.98

Sequence Information

Coding Sequence
ATGGCGCGCTACTCCCCCCACTACCCGCACTGTGACCAATCGGAGCTTCTGAATGGAGGAAAGCTGCCAGGTTATGCTTGTTACCAGTGTGCTGCATTAATCAAGAAGTGGTATTTATTCAGAGAAAAATGCTCTAAGGGTCAATCAATTTTGTTTAACATATTAGCAACTACAGGCGAGATCACCTACGAAAATGTTGCTCAAATAGACAGagacaagttaaatttgacatcCAGTATTATTATCAATCACAACGTAAGCACAATCTCAAGCCAAGAATTATTGCAAGATGAGGATTTAAAAGACTTCAAATCTGAAAACACACAGACAACAGTAGATGCTGGTGATAATTATGATGAAGGCTTTGATAATTATGATGAGAAGATAGACATTGAAATAGATGCTTATTGTGGTGTAGCCACACTACAACATCTTtctagtgatgatgatgaaccactGTCTATTCATAAAAGCAACAAAGAAAAGAAGAAATCCGAAAAGAAAAGAGGGcgaaaaaagaaagaagtaaAAGAAGAATTAACAGAAGCTATTGAGAAAGCTGAAAGTATAGAGGTTTCACAAGATATATCAGAGTTACTGCCATTGTTGGAAGAAATGCCCCCCAAGAAGAAAAGAGGGCGTCCTCCAAAAGCGGCCACTTCTAGCATTTCTGAAGGGAAAGAGAAGAAACAGAGACGAACACAGAACACTGGTGGTGTTGACATTGAAGAAATTGATTTGGATGAATATGTTAATGTTGTCAAACTAACCCTTAAAGAACAAATCGAAGAGGTCACTATGCGACAACACACCTCCAACTACATGAACGCCCCCTTCCAGTGCAACCTCTGCTACAGGGGCTTCATTGACACCGACGCGTGGAATCACCACATCGAGAAACATAGTCAGAGCGCGGGCGACGTCGAGTGTCCGGTGTGCAAATTCAGGTTTAAGACCAAGAGAGCACTGCAGAAGCACTCCGCCAACCACGAGAAGAAATACGCGTGCAAATCTTGCTCGTATGTTTCGAAAACTACaACGCAGGCGAAGCAGCATCAGCGATGGCATAAAGGGGTCACCTACAAATGTCAGCATTGCGATGAGGTATTAGTCAAGTGGACGTCGTACCTGAGCCACGTGCGGATCAAGCACCCGTCGGAGTTCATCTGCGACGTGTGCGGCTACTCGTTCGTCAGCAAGCTGGGCCTGGCCATGCACCGCACCATGATGCACAAGGAGCTCGTTGAGAAGGAGGCCGCGGGCGATGTGACCAAAGAAGGCCCTTTCTGCGCGGAGTGCGACGTGGCGTTCATATCGGAGGAGGCGTACAAGCGACACATGGTCACCTCTGTCAAACACATACACAGCTCCAACTTCCAGAACGGGTGCCGCGTGTGCGGCGGCGTGTTCACCAGCTCGGAGGAGTTGCGGCTCCATCATCGCCGCGAACACGCGCGCAAGCGGCCCAAGAACTACGGCAAGAGGCAGCAGCCGGCCGCCTTCCCCGTCGACTGTCAGTACTGCTCGGTGCAAATGGAGAACGCGCGTCAGTACTGGGCGCACTTCAGGCGCGTGCACCCCGACAAGAACTATCCTATACGCAAGGACTACGTGTGTGATGTCTGCGGCAAGAGCTTTCGGGGCAACGCGTTCCTGGTGTACCACAAGCGCACGCACCAGGAGGAGCGCATGTTCCCGTGCGCGGCGTGCGGCAAGGCGTTCTACAACCGTACCAACCTGCACATGCACGCGCGCACGCACTCCGACCTGCGGCCCTACCCGTGCTCCGTGTGCGGCAAGGCCTTCAAGTGCAAGGGCGCGCTCGACAGGCACTTCAGGAGCCACACGGGCGTGAAGCCGTACGTGTGCGAGGTGTGCGGCAAGGCGTTCGGGCAGTCCAACAGCCGCAAGCTGCACGTGCGCACCGTGCACCTGCGGCAGCCCGCGCCGTACGTGTCGCGCGCCCGGCAGGAGCGGCGCGCGACGCGCACGGCGCGGGaccagccgccgccgccgccccatCCACCCCCGCCGCCCCCACCGCAGTTCCCGTGCGAGTAG
Protein Sequence
MARYSPHYPHCDQSELLNGGKLPGYACYQCAALIKKWYLFREKCSKGQSILFNILATTGEITYENVAQIDRDKLNLTSSIIINHNVSTISSQELLQDEDLKDFKSENTQTTVDAGDNYDEGFDNYDEKIDIEIDAYCGVATLQHLSSDDDEPLSIHKSNKEKKKSEKKRGRKKKEVKEELTEAIEKAESIEVSQDISELLPLLEEMPPKKKRGRPPKAATSSISEGKEKKQRRTQNTGGVDIEEIDLDEYVNVVKLTLKEQIEEVTMRQHTSNYMNAPFQCNLCYRGFIDTDAWNHHIEKHSQSAGDVECPVCKFRFKTKRALQKHSANHEKKYACKSCSYVSKTTTQAKQHQRWHKGVTYKCQHCDEVLVKWTSYLSHVRIKHPSEFICDVCGYSFVSKLGLAMHRTMMHKELVEKEAAGDVTKEGPFCAECDVAFISEEAYKRHMVTSVKHIHSSNFQNGCRVCGGVFTSSEELRLHHRREHARKRPKNYGKRQQPAAFPVDCQYCSVQMENARQYWAHFRRVHPDKNYPIRKDYVCDVCGKSFRGNAFLVYHKRTHQEERMFPCAACGKAFYNRTNLHMHARTHSDLRPYPCSVCGKAFKCKGALDRHFRSHTGVKPYVCEVCGKAFGQSNSRKLHVRTVHLRQPAPYVSRARQERRATRTARDQPPPPPHPPPPPPPQFPCE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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