Basic Information

Gene Symbol
-
Assembly
GCA_951805265.1
Location
OX638203.1:15130151-15132899[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 0.28 19 6.1 3.7 2 23 50 71 49 71 0.96
2 20 0.002 0.14 12.8 3.4 1 23 76 99 76 99 0.94
3 20 6.5e-05 0.0044 17.5 5.1 1 23 105 127 105 127 0.96
4 20 0.0036 0.24 12.1 0.7 1 23 133 156 133 156 0.96
5 20 0.047 3.2 8.5 5.1 1 23 161 183 161 183 0.98
6 20 0.0032 0.22 12.2 1.5 1 23 191 212 191 212 0.97
7 20 6.7e-07 4.5e-05 23.8 0.1 1 23 218 240 218 240 0.98
8 20 3.3e-07 2.2e-05 24.8 0.8 1 23 246 268 246 268 0.95
9 20 2.9e-07 1.9e-05 24.9 0.9 1 23 274 296 274 296 0.97
10 20 3.6 2.4e+02 2.6 0.2 1 12 302 313 302 318 0.85
11 20 0.13 9.1 7.1 1.4 1 20 332 351 332 354 0.95
12 20 0.0032 0.22 12.2 4.1 1 23 359 382 359 382 0.95
13 20 8.5e-05 0.0058 17.2 1.2 1 23 388 410 388 410 0.96
14 20 0.0039 0.26 11.9 1.7 1 23 416 439 416 439 0.98
15 20 2.9e-05 0.002 18.6 5.3 1 23 444 466 444 466 0.98
16 20 0.00013 0.0086 16.6 0.1 1 23 474 496 474 496 0.98
17 20 2.8e-06 0.00019 21.8 0.0 1 23 502 524 502 524 0.98
18 20 8.8e-07 6e-05 23.4 0.4 1 23 530 552 530 552 0.98
19 20 1.6e-06 0.00011 22.6 0.8 1 23 558 580 558 580 0.98
20 20 0.38 26 5.7 3.5 1 20 586 605 586 606 0.95

Sequence Information

Coding Sequence
ATGGTGACGCTCCGAAAATTCGCCGTGGCCGCAAAAATTGACTTCCATTTCCTGTTTAGGAGGAAACGGTTTTCCGCTGGTCCTCTGGTAATATCGGACATCGTGAAAGCCGACCCCGATTTGCAGTCTGAATCACCAAATTTGATCCGTTGTAAAACTTGCTGCGCCAGTTTTCCAACAAGCCAGCGTCTGAGGAAGCACGAACGCTACCACCAAGAGAAAATCCACAATTGCAACTTGTGCGAGAAGAAATACACTTTTAAATATCAGTTAGTGCAACACGTCAAACAAGATCACGAGGACCACGAACCGTATTGTTGCCAAGTTTGCAacaagaaattcaaaaataaagtttacttGCAGCGCCACTTCCTCATCCATTCAAAAGGATTTAAGCACAAATGTGATCAGTGTGATGCGACGTTTCTGAATCCTGGCGAATTGAAGCTGCATAAAAACGTCCAACATGAGGGACACCGCTTCAAATGCGAACAATgtgagaaattatttaaatgtcGTGACTTTTGGCGAAGGCATATGCGCGATCACGAAACAGGCTATAGAGAAACTTTCATTTGTCCCGTTTGTTCCAAAGTGTTGACAAAAAAGGGATTGCACAATCACATGAAGCAGCATGGTGACGGTGAAAGCTACATGTGTGACGTTTGTGGGAAAAGTGTGACTACTGCTGCTTCGTTGAAGGACCATATGAAGGTTCATAACGGAGAGAAGCCGTTTCTTTGTGATTATTGCGGAAAAGCGTTTAGTAGACGGGACTACTTGGTGACACACCGACGGGTTCACACCAAAGAAAAACCTTTTGCTTGCAACGATTGTGGCAAGAGTTTTACGCAATTGGGGAGTCTTAAAATACACAAGCGATATCATACGGGGGAGAAACCGTACAAGTGCCAAGTTTGCTCGAGGGGGTCTTCCACCCACCCTCTGGTTACTTCGAACATTATCGACATTATCGATTCGAGTTCAACATTATTTCGTTGCGACGTATGTGATGCGGCATACCCAATCCGATGGAAACTGAGGAAACACCGATACTGCCATCAAGAAAAACTGCACCAGTGTAACTTGTGCGCCAAGAAATACACCTACAGACACCAGTTAGTACAACACATTAACGATAACCATGACGAGAAGGAAGCCCACATTTgtgaaatttgcaacaaaaaattgaaaactaaagTTTCTCTCAAGGGCCACATGCTTATACACACTAAAGAACATCAATACAAATGCGAACAATGCGAATCAACGTTTCTTAAGGCCTATCAGTTGAGGAAGCATAAAAGGATCGAACACGAGGGCCATCGCTATAGTTGCAAGCACTGcccaaaagtttttaaatgtcCTTCATATTGGCGACGGCACATGCGCGTTCACGAAGCCGGTTATAAAGAAACCtacatttgtaaaatttgctccAAAGTATTGACTTCGAGGCCGGGGTTGGTTGAGCATCTGAGACGGCATACTGACGACAAGAACTATATTTGTGACGTTTGCGGAAAAAGTGTCAATAGTGCTGCGTCGTTGAAAGACCATATGAAGATTCATACCGGAGACAAAACGTTTGTTTGTGATTATTGCGAAAAAGCGTTCACTAGACGAGTTTATTTGGTAGCCCACAGGAGGGTTCACACCAAGGAAAAGCCATTTTCTTGCGGCGATTGCGGCAAGAGTTTTTCGCAAATGGGGACTCTTACGATACACAAACGGTATCATACCGGGGAGAAGCCATATAAATGCGATATCTGCTGTAAAGCGTTTGTTTCGGGGACTTTGCTCAAAAATCATAAGTGCTGA
Protein Sequence
MVTLRKFAVAAKIDFHFLFRRKRFSAGPLVISDIVKADPDLQSESPNLIRCKTCCASFPTSQRLRKHERYHQEKIHNCNLCEKKYTFKYQLVQHVKQDHEDHEPYCCQVCNKKFKNKVYLQRHFLIHSKGFKHKCDQCDATFLNPGELKLHKNVQHEGHRFKCEQCEKLFKCRDFWRRHMRDHETGYRETFICPVCSKVLTKKGLHNHMKQHGDGESYMCDVCGKSVTTAASLKDHMKVHNGEKPFLCDYCGKAFSRRDYLVTHRRVHTKEKPFACNDCGKSFTQLGSLKIHKRYHTGEKPYKCQVCSRGSSTHPLVTSNIIDIIDSSSTLFRCDVCDAAYPIRWKLRKHRYCHQEKLHQCNLCAKKYTYRHQLVQHINDNHDEKEAHICEICNKKLKTKVSLKGHMLIHTKEHQYKCEQCESTFLKAYQLRKHKRIEHEGHRYSCKHCPKVFKCPSYWRRHMRVHEAGYKETYICKICSKVLTSRPGLVEHLRRHTDDKNYICDVCGKSVNSAASLKDHMKIHTGDKTFVCDYCEKAFTRRVYLVAHRRVHTKEKPFSCGDCGKSFSQMGTLTIHKRYHTGEKPYKCDICCKAFVSGTLLKNHKC

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-