Spec013900.1
Basic Information
- Insect
- Schizotus pectinicornis
- Gene Symbol
- Runx3
- Assembly
- GCA_951805265.1
- Location
- OX638208.1:4008076-4018207[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 2 3.2e-74 8.9e-71 235.6 0.0 4 129 35 160 32 160 0.98 2 2 2.3 6.4e+03 -3.2 0.0 7 30 432 455 429 456 0.76
Sequence Information
- Coding Sequence
- ATGCACCTGGCTAGCGAAGTGAGCTCGACCACCGGCGGTCATTATGACCGCAACTACGGCAACTTGACCGCCGAGATGCTGGCCGAGAGGACCATCGATGGGCTGTTGGCCGAACATCCGGGAGAGTTGGTGAGGACGGGGAGTCCGCATGTGGTCTGCACGGTGTTGCCGCCCCACTGGAGGTCCAACAAGACGTTGCCGGTGGCCTTCAAGGTGGTGGCGCTCGGGGACGTGGGCGACGGCACCGTCGTCACGGTCAAGGCGGGCAACGACGAGAACTACTGCGCCGAACTCAGGAACTGCACGGCGGTCATGAAGAACCAAGTTGCCAAGTTCAACGATCTCAGGTTCGTCGGCAGGAGCGGAAGAGgCAAGAGCTTCACTTTGACGATCATTGTATCGACGTCGCCGCCCCAGATCGCCACCTACAACAAGGCGATCAAAGTGACCGTGGACGGCCCCAGGGAGCCCCGATCGAAGACGAGGCAGCAGGGCTTCCACCACTTTCCCTTCGGGCCCAGGCCCTTCGCTCCCGACCCCCTCACCGGCGGACTTCCCTTCAAACTGAGCGgaATCGCCCACCATCTGGCGGGTTTGCCCGGCCCTCCCCCCGACTGGGCGATGCTGGGGGGTCGCCACCCTTACCCCCCCGGCCCTTTCGTGCCGCACCCGCACCCCCACTTTCCTCACCACATGTTCGCAGCCCTCGACCGTCCAATCAACACATCACCGAGAATAGCAAGCGAACCGACCTCGACCTCGTTGGGTCCCATCTCGATAAATTGCAGCACAACAACCGCCCATAGTACCACATCGCCGAAAACCTCCCCGACTCAAGTGGGTCTACTAACAACAGCCCCTTTATCACCCCCCGAAGACGACATATCTGTAACGGCATCACCCACACCGTCCCCTCAACCACCACCGGCGTTTCCGGGAGCACCACCGCCACCTCTCCAGAACAACCAATTGTTCAACAACGCATTGGCGGCCAGTCTATTTTTGAACGCACCTCTTCTACCACCGCCGGGACAATGGTTCTATTCCCAGTTTTATCCCCACGATTGGGCCTGGATGAATTTGAGACATCACACGTTGTTGCCGAGAGGCAACGGCAATTCACCTCACGATCTCAACCAAAATCCGGATAGTTCCAGTAAGGCCGAACTGACGGAGATTGAGGACAATAAAAGTGACGATGGAAAAGATGGGAAGGAAGAAAAGAAAGGGGCGAAAGATGAAGGGATGAATTTGTCGCTACACAGATGCAGGAAAGCTGCTATTACGTTAGTGAGACAAAAGGATGAGGTTAGTTCTAGCGACAAAGAGCATTTGAAGTGTAATAGACTGTCGGATGTGTGGAGACCTTATTAG
- Protein Sequence
- MHLASEVSSTTGGHYDRNYGNLTAEMLAERTIDGLLAEHPGELVRTGSPHVVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTVVTVKAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIIVSTSPPQIATYNKAIKVTVDGPREPRSKTRQQGFHHFPFGPRPFAPDPLTGGLPFKLSGIAHHLAGLPGPPPDWAMLGGRHPYPPGPFVPHPHPHFPHHMFAALDRPINTSPRIASEPTSTSLGPISINCSTTTAHSTTSPKTSPTQVGLLTTAPLSPPEDDISVTASPTPSPQPPPAFPGAPPPPLQNNQLFNNALAASLFLNAPLLPPPGQWFYSQFYPHDWAWMNLRHHTLLPRGNGNSPHDLNQNPDSSSKAELTEIEDNKSDDGKDGKEEKKGAKDEGMNLSLHRCRKAAITLVRQKDEVSSSDKEHLKCNRLSDVWRPY
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00852455;
- 90% Identity
- iTF_01409728;
- 80% Identity
- -