Basic Information

Gene Symbol
-
Assembly
GCA_003264975.1
Location
QEWZ01001524.1:563760-569758[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 8 0.00047 0.046 14.7 0.3 1 23 170 192 170 192 0.98
2 8 9.5e-07 9.2e-05 23.2 1.1 3 23 200 220 198 220 0.97
3 8 0.00012 0.012 16.6 0.1 2 23 249 270 248 270 0.96
4 8 3.6e-06 0.00035 21.4 0.4 1 20 303 322 303 324 0.96
5 8 1.8e-06 0.00018 22.3 0.6 2 23 333 354 333 354 0.98
6 8 1.2e-07 1.2e-05 26.0 0.5 1 23 360 382 360 382 0.98
7 8 5.2e-06 0.0005 20.9 1.2 1 23 409 431 409 431 0.98
8 8 1.9e-06 0.00019 22.2 7.9 1 23 437 460 437 460 0.96

Sequence Information

Coding Sequence
ATGGACCAAGAAAATCAGGGTGTTATTTATATCGAAAATTGGAATGACTTATGTCGATTGTGTCTACGCAATGAACAATCATTGCAAAATCTGTTCTTTGAAGAAACTCTTTTGGAAAATATTCAAGAAGTCACGAATCTTCATtttaatgttgAGGATTCTTTACCTAATTCTATATGCAAAATATGCATCGAACAAGTTAATTCATTTGTTGAATTTCGAGTACGATGTAAAGCTACTGATGAATGGCTACGAAATGAAGCAGTAATTTTGGATAATGATAACAAGgATTCTATAATAGTTGATTcagaagaaattaataataaagatttattattagtgGAACCAAATCAATACGAAGAGCAGTTAATTGATGATCCAGAACCTGTTAATAATAAGCAAATAGTTGAAAATGAAATTGAGTTATCTCATTGCATTGTTCAAACAGAAGAGGTAATGCAAATGTCAGTTAACGAAGAAGAGACTTTAGAAACAAATTCTAGTGATCATCAATGTGCAATTTGTGGTAAAGAGTTGTTGTCTGCATATACACTTGCAAACCACATGCGATCCCACACAGGAGAGCGTCCTTATGGATGCAGTGTTTGTGAAAAGTTCTTCAAGACTAAATCCAATTTAAATGAACATTACCGaGTTCACAATCCGGAACTGCGTTGGATGAAGACGTCTAGCAGGGACATCCCGTCCATAACCCGAGTGACGGTCACGTCCGAAGATATTCTGACGTGCGGTCAGTGTTCTAAGGTGTTCGTATCACTGGACGAATTGTCTGCTCACGAACGCGAGCACGACGATCAGCGAGAACAGCCGGAACAGGTGACGCAGACAGTCGAGGCGACGATTTCACCGGCGGCAGTGACGTCGTCTGCGCCTGCGGCGACTACGTTCACTTGTGAACAGTGCAACAAAAACTTCACGTCGAAGTCGCAACTGTCCGCGCACATCGGTAACAACTGTTCGGAAAACGCTGACCGACAGTGTCCGTACTGCGGCAAGCAGTTTCGGTCGATGGCCACGCTGGAGAACCACAAGCGGGTGCACACCAGGGAAAAACCGTTCACGTGCGAGCTGTGCGGCAAGGCATTCCGCACCAAGGGAAATCTGCTGGAGCACAAGCGCGTGCACAACAACAGCCTGTGCCTGATGAAGAGCGACGCGAAGATGGCCGACCGCGACGCGGGTGCGGGCGGCTGCGACCAGCGGTTCCAGTGCACGTACTGTTCGAAACCGTTCCGGACGTACACGGCGCTGTTGAATCACGAGCGCGTGCACACCCGCGAAAAGCCGTTCGAGTGTTGTGTGTGCGGCAAGTGTTTCCGAACCAAATCCAACCTGACGGAGCACATGAAGGGCTGCCACGACATGGACTCGTCGGCCTGCGGCTCGGACGAAGTCCAAGTGTTCACGTTCAAGACCCAAACGGTGGCTGCCGCCGAGCTGGAGTCCACGTGA
Protein Sequence
MDQENQGVIYIENWNDLCRLCLRNEQSLQNLFFEETLLENIQEVTNLHFNVEDSLPNSICKICIEQVNSFVEFRVRCKATDEWLRNEAVILDNDNKDSIIVDSEEINNKDLLLVEPNQYEEQLIDDPEPVNNKQIVENEIELSHCIVQTEEVMQMSVNEEETLETNSSDHQCAICGKELLSAYTLANHMRSHTGERPYGCSVCEKFFKTKSNLNEHYRVHNPELRWMKTSSRDIPSITRVTVTSEDILTCGQCSKVFVSLDELSAHEREHDDQREQPEQVTQTVEATISPAAVTSSAPAATTFTCEQCNKNFTSKSQLSAHIGNNCSENADRQCPYCGKQFRSMATLENHKRVHTREKPFTCELCGKAFRTKGNLLEHKRVHNNSLCLMKSDAKMADRDAGAGGCDQRFQCTYCSKPFRTYTALLNHERVHTREKPFECCVCGKCFRTKSNLTEHMKGCHDMDSSACGSDEVQVFTFKTQTVAAAELEST

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00184787;
90% Identity
iTF_01304365;
80% Identity
-