Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 7 1.9e+04 -12.6 9.5 57 71 85 99 74 106 0.51

2 2 1.4e-53 3.9e-50 168.8 0.2 4 109 135 240 132 267 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	7	1.9e+04	-12.6	9.5	57	71	85	99	74	106	0.51
2	2	1.4e-53	3.9e-50	168.8	0.2	4	109	135	240	132	267	0.90

Coding Sequence: ATGCACATTACGGCTGAGGTCAGTTCGACCACCTCAAAtcaaacacagcagcagcaacaacaacaaaaccagcagcaacaacaacaacaccagcagcaacaacatcatcagcagcagcagcagcaacaagcaacaccgcagcagcaacagcatacaacggcaacaacaacaataacaacaaccggCAGCACAACGAAGCGACGAAGCAATGCCGaatcaaataacaacaataacaacaatagcacaactaataacaataacaacaacaacaatagcactacaaacaataataataataacattaataataataataccaatggcaatggcagtaAAAGCAAACCCATTGATACAAGTCCATATTTGACGCCCGAGAATCTGATCGAACGCACCGTCGATGTCCTGCTAGCCGAACATCCTGGCGAACTTGTCAAAACGGGCTCACCACACGTCGTGTGCACAACGCTGCCCACGCATTGGCGCTCTAATAAAACCCTGCCAATTGCCTTTAAGGTGCTGGCGCTGGGCGAGGTCATGGATGGCACAATTGTCACAATACGTGCCGGCAACGATGAAAACTTTTGCGGTGAGCTGCGCAACTGCACCGCCGTCATGAAGAATCAGGTTGCCAAATTCAATGATCTACGTTTTGTGGGACGCAGCGGCAGAGGGAAAAAGTTTTGCGCTCACATCATTGGTAGCTCagttacagcaacagcaacaacaacaacaatagcaacaacaacacaacaacagcaaaacagcaacaacatgaagAATAAAGTCAACGTCACTGACACTGCCCTTGGGCCATGTATTACAAATCGGGTTAAACGGCTGCCAAAGAACAAAACGGATGtcaacacagcagcaacaacaacaacaacaacaacaacaaggactAAAACGGCAAAATGTCGCGCTAAAAAGGGttaa
Protein Sequence: MHITAEVSSTTSNQTQQQQQQQNQQQQQQHQQQQHHQQQQQQQATPQQQQHTTATTTITTTGSTTKRRSNAESNNNNNNNSTTNNNNNNNNSTTNNNNNNINNNNTNGNGSKSKPIDTSPYLTPENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRAGNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKKFCAHIIGSSVTATATTTTIATTTQQQQNSNNMKNKVNVTDTALGPCITNRVKRLPKNKTDVNTAATTTTTTTTRTKTAKCRAKKG

Sequence clustering based on sequence similarity using MMseqs2