Sleb013024.1
Basic Information
- Gene Symbol
- -
- Assembly
- GCA_003285725.2
- Location
- NW:9707549-9710627[-]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 12 0.059 3.7 7.8 5.9 3 23 259 279 257 279 0.96 2 12 0.003 0.19 11.9 0.5 1 23 285 310 285 310 0.92 3 12 0.0028 0.17 12.0 0.7 1 23 317 342 317 342 0.93 4 12 0.00022 0.013 15.5 2.0 1 23 354 376 354 376 0.98 5 12 2e-06 0.00012 21.9 0.2 1 23 383 405 383 405 0.98 6 12 0.0058 0.36 11.0 0.1 1 23 411 433 411 433 0.98 7 12 0.0056 0.35 11.0 4.0 1 23 439 462 439 462 0.98 8 12 0.0076 0.47 10.6 3.9 1 23 468 490 468 490 0.96 9 12 0.00013 0.008 16.2 3.6 2 23 497 518 496 518 0.96 10 12 3.4e-05 0.0021 18.0 0.3 1 23 623 646 623 646 0.96 11 12 0.009 0.56 10.4 1.2 1 19 652 670 652 674 0.94 12 12 1.5e-06 9.2e-05 22.3 4.1 1 23 680 702 680 702 0.99
Sequence Information
- Coding Sequence
- ATGAACGTGGGGAGTGCATACTCCATACACACGGTGTGTCGCATTTGTTTAAAGTACCTGCAAAACGATGCTGCGTACGACCTCTTTTTGGTTCCTGGACTGGCGAAAAAACTCTGTGTGTGCACGTCGTTGTCAGTCGAGCAGCAAGACGGATTTCCAAAAAATTTATGCTCCAATTGTTACACCAGGTTGAACGACATGCACGATTTTCAGAAACTTTGCGTCGATTCTGTGCAGAAGTTTCAAGAAATGGTCGCAAGCAATGTATTCACTTGTCAAGTTAGCAGCTTCGATGTCATGGACCCGGTTGTAGCTAATGAGGCAGAATTGGCGGCCGAAGATGAGGATCGAATTAACTACGATCCCCTGCTTAACCATAAAATGGAGTTAATTGAAAATGAGGAGGATGTATTCAAGATGTTGGAACATGTAGATAAAGAGGCCGAGGACGTGCTTAACGAAGTCAAGCATGATGAGGCAGcatttgaaatcaaaatattcGACAACGAACAGTCCTCTTTTGAAAGTGACAATGACAATGACAACGATGTGGATTTTGAGCCCAACAGTAGTGATGACGATATGCCGCTGGCGCAACGCCTACGGGGCTCTAAGCCCAAAGGTGCATCCAAGACAAAATCCAAGCAAAAAGTTcctgatgatgataatgatttTAGCTCCGAGTCCGATGACGATGAGGACGATGATGACAAAGAAAGACCAAAGCGCAAACGCATTCCGGCGGCTGAGCGCCACTTGCATCGTATCATTGATTGCCACATTTGTCAtcagaaattcaaaaaagctATTAGATATGAGGAGCACATGAAACATCACAATGATTTGCTGCCGTTTCAGTGTAAGGTGGAAACGTGTAGAAAAGGTTTTACAACTGCCGGTGGGCTGCGCCTTCACGTTGACCATGCGCACACGGAACTATCCGAGGTGCATGCTTGCAATGTTGAAGGATGCGGCAAGACATTCCCCCGCATTCGCCTGTTGACTTTCCACATGAAGAAGGTGCACAACATATCGAAGGCATCGGCGCCACCAAGGGATTACCCCTGCACCGAATGCGAAAAGGTTTTCCGTTGCCCCATGGCCTTAAAAAAGCACATGTACAAGCACGATGGCAAGGAGCTACCATTTCCATGCAACATCTGCGGTAAACGATTCGTTATTAACAGCGCTCTTAAGGATCACCTTATGCGACATGCCGGTATTAAAAACTATGTATGTCCCTACTGCGGTGTGGGCAAGACCACTCGTCAAGAATGGAACACACACATCCTTACCCACACCCAGGAGAAGAAGTTCAAATGCCATATCTGTGAGCATGCTTCGCACAATAAACAGAGTCTGGCCAATCACATTAAGATCGTTCACGAAAAGATCAAGAACTACGCTTGCCAATACTGTGGCAAAACATTTGGCAAGTCACATGCTTGTAAGATCCATGAGATGACGCATACAGGCGAGAAGCGTTGCGAATGCAAGGTGTGTGGCAAGAAATTCCTTTATCCAAAGAGTTTAACAAAACACTTGAAGACGCACGAGAAACGCGTTCTTCGTGCTATTGAAACTTACCGGCAGCGGCAAGTGGAGCTTGGCGAAGGCTCCACCGAGCAGGCAGACAATCCACCGGAAGGTATACCTGCCAGTGTAGAGACTGAAGGTCTCTCTCAAAATGCCGCAGATGAGTTGCTTAAGGTTTGCGCCGAGTCTGTGGCTACAATACCAAAAGATCCTCGTCGAGTACAACGTGTTGACATCTCTCAATTGGCGGGCACCGCTGTAAATCCCATACCCTCAGTATCGGTCCCATCCTGGTCACCACAAGTGAACTTTACCAAAAAGGAGGGTAAACATATTTGTCCCGGCTGTGGCCAAGGCTTCAACAACATCGGCAACATGAAACGTCACTACAAAATCATACATGAAAAGGTCAAGGACTTCGCCTGCCGCTTTTGTCCCAAACGCTTTGCAAAAGCACAAACGCTTCGACATCACGAATGGATACACACTGGCGAAAAACCGTTTGAGTGTAAGACATGCGGCACGCATTTCCGTCAGGAGACAGCGCTCAAGCGGCATCAAAGGACGCACGAGAACAGGCCGCCTGTCATCTCATCCAAGTTCTACGCCGCCCGCGAAGAGTTGGAGGAGCAAGAGCGCAGAAAACGGGAGGCTAGACGCAAAGCAGACGCGAAGCGAAAGGAAATTGCGGAAGCGGCAAAAGAGCAATTACAGACGCTGCACAAAATCGAAGCAACGGACAAGAATTTGCACTCTTATGATGAGTACCAGGAAGCAGCCGCAGAGCGGGCAGCCGCCTCTGCAGAATTGCAGGCTCAACAGTTTGAAGAGAACGAGATAAAGCGCAAAGCGGAGGAAGAACGCCGGAAGGTTCAAGAGGCTGCCTACGAGCAGTTACAAatactgcaacagcaacaggaaaTCGAGAAAGCTCAAAGCTCCTACGATGGGTACTTTGCTCAAAAAGCGCACGCTGATGGAACCAGCCTCGATGCCCTCAAAATAGACCATGTGTGA
- Protein Sequence
- MNVGSAYSIHTVCRICLKYLQNDAAYDLFLVPGLAKKLCVCTSLSVEQQDGFPKNLCSNCYTRLNDMHDFQKLCVDSVQKFQEMVASNVFTCQVSSFDVMDPVVANEAELAAEDEDRINYDPLLNHKMELIENEEDVFKMLEHVDKEAEDVLNEVKHDEAAFEIKIFDNEQSSFESDNDNDNDVDFEPNSSDDDMPLAQRLRGSKPKGASKTKSKQKVPDDDNDFSSESDDDEDDDDKERPKRKRIPAAERHLHRIIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCKVETCRKGFTTAGGLRLHVDHAHTELSEVHACNVEGCGKTFPRIRLLTFHMKKVHNISKASAPPRDYPCTECEKVFRCPMALKKHMYKHDGKELPFPCNICGKRFVINSALKDHLMRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIKNYACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIETYRQRQVELGEGSTEQADNPPEGIPASVETEGLSQNAADELLKVCAESVATIPKDPRRVQRVDISQLAGTAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRFAKAQTLRHHEWIHTGEKPFECKTCGTHFRQETALKRHQRTHENRPPVISSKFYAAREELEEQERRKREARRKADAKRKEIAEAAKEQLQTLHKIEATDKNLHSYDEYQEAAAERAAASAELQAQQFEENEIKRKAEEERRKVQEAAYEQLQILQQQQEIEKAQSSYDGYFAQKAHADGTSLDALKIDHV
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00575777;
- 90% Identity
- -
- 80% Identity
- -