Basic Information

Gene Symbol
MET31
Assembly
GCA_003285725.2
Location
NW:12938039-12942129[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.4 25 5.2 2.4 1 22 166 187 166 188 0.77
2 17 0.00032 0.02 14.9 0.4 1 22 194 215 194 218 0.91
3 17 2.2e-05 0.0013 18.6 4.4 1 23 333 355 333 355 0.99
4 17 0.00032 0.02 15.0 0.6 1 23 361 385 361 385 0.92
5 17 2.7e-05 0.0017 18.3 3.6 1 23 498 520 498 520 0.98
6 17 0.00047 0.029 14.4 0.2 1 23 526 550 526 550 0.91
7 17 7.6 4.7e+02 1.2 0.4 1 23 625 649 625 649 0.75
8 17 0.00029 0.018 15.1 6.4 1 23 655 677 655 677 0.99
9 17 0.0018 0.11 12.6 1.5 1 23 683 707 683 707 0.92
10 17 0.0024 0.15 12.2 2.2 2 23 760 781 759 781 0.96
11 17 7.9e-05 0.0049 16.8 1.5 1 23 787 810 787 810 0.97
12 17 0.25 16 5.8 0.9 1 23 816 840 816 840 0.95
13 17 2e-06 0.00012 21.9 6.4 1 23 846 868 846 868 0.99
14 17 1.2e-05 0.00077 19.4 6.1 1 23 874 896 874 896 0.99
15 17 7.3e-05 0.0045 17.0 0.3 3 21 911 929 910 930 0.94
16 17 7e-05 0.0044 17.0 1.6 1 23 937 960 937 960 0.97
17 17 0.058 3.6 7.8 3.2 1 23 996 1018 996 1018 0.97

Sequence Information

Coding Sequence
ATGGCTTCCAAGCCTTCATGTAGAACGTGCGGTGGATGCAAATACAAAGGAAAGGCCAAGCCCctatttaaaaatgaagctggcaatgaaattttgaactacataaaaataataactggTCTCGGGTTGGATGATTTGCCTAATATGCCAGGGCATATATGTATGACCTGTGAATATCATTTGGATCAAGCGATTTCCTTTCGGGAACGATGCATACGCACGCATGAAATATTTTCctctataaatattcaaagtggaaaaaatagCGAAGAAAATTTAAccattttatcaatttttgataaaacaGACCTTAATTATCACTCAAACTCTATTGAGGAGGAACATGAAAACAATGGTACGATTTCTCAACCATTGATTGATAAAAGTTGTGTCATAGTATTAGACCAAAAAGATGTTCCTGAGGAAAATTGCGTGACACCGAATAAGCAGTTGGAAGCAAAGTCCTCAAAACATCAAAATAGGCCCGTTTATCCATACAAATGTCTGTACtgtgaaaaacaatttaagaGTACAATAATCCGTGCGAAGCATCATAGAGCCCATGCAGGAGAGCGccaatacaaGTGCAAATTGTGTAACATGTCTTTTGAGCAGGCCCGATATTTAAAAGGACACATAGATTCTGAAGGccatcaaaataaaatggctGCGGGAAACTccatattaataaataatcaaaacacTTCTACAAACAACCGTAATAAATTTTGCGCAAACCCACCAATTGAATACAATGATGTCAATAATTCAAATCGGTTTGACAACgcctttgaaatatttttaaaaacagatCAAACACAGAACGATGAAACCAATAATCTCGCTGCAGTAGATCCAATCGCCACCGCCTGCGAAATTGTTAAAGCTCCAGTAAAAAACGATCAACAATATAATTTAGATGAAGAACAAAGCAATGAAGCCAGTGCTGATTTCGAAAATGTTATGTGCGAGAGAGCTCAGATGGGGAAGAATCGGTACAAGTGTAAGTATTGCGACAAGAGATTTAGCAAACCATCAAACTGCAGGGCACACGAGAGAGTGCATACAGGAGAGCGACCATTCCAATGTGAAAATTGCGATGTATCATTTAAATGGAAACAGAGCTTAAAAAGGCATATAAACTCCCTGGGACACCAAAATAATGAAGGCTTTAGAGATGAcgaaacaaaatgcaaaagaaacCATAAAAACACGGAACATAAAGAGGTTTGCATACATGATACTGAAGGAGAAGAGAAGTCTACTAGTCTTCAGAAGTTATTGGAATTCAGCACGGGAAAGGAAGAGAATACTTGTAAAACAGTTTCAAAAGTAGATCAACAATCAGTCGAAAATAACCGATGCTTTGAAGAACATGAAGACATTAACGCCGCTACTCTTGATCCCACTGACAACGTGCATGAAAGCAATTCTGCCATTTCTCTACTGGAAGGGGCTGTTCTGGAAAGAGCTGAAGAAGGCGGAATTCGGTACAATTGTAAGTACTGTGGGAAGAGATTTACTAAGCCTTCAAATTGCAGAGCGCACGAAAGAGTACATACTGGAGAGCGACCATTCATATGCGAAATTTGCGATGTGTCTTTTAAATGGAAACAAAGTTTACAGAGGCATATAAACTCCCTGGAACATCAAAATAATAAGAGCTTTAGTTCTGAAAATACcgtaaaatgcaacaaaaactatGAGAATACCGAACATAAAAGGATAATGGAGTTTCGCGCAGATTACACTAAAAGAGAAGACAAATGTACAAGTGAACCAAAGCCACAAGAAGCAGACATGGAGAGCCAGGAATGCAGCTCGAAGGCAGAAGATAACAATGAGTTATTATTGACAGCGTCATTGTCGAAGTTTATTTGTGGAAACGAAGACTGTAATATTGAATTCAAATCGAATTTATCAAGGGTTTTCCACGAGAGAACTCATAAGGGAGAGCTTCGGTACAAGTGTAAGTACTGTGACAAGAGATTTGATAAATCATCAAACTGCAGGGAGCACTACAGAGTTCATACTGGAGAGCGACCATTCAAATGTGACATTTGCGAAGTGTCGTATAAATGGAGCCAACATTTAAAGAGGCATATAAAGTCCCTGGAACatctaaataaaaagaatgctACTTTAAATCCGATTGACAACGCCCAATTGTCAAGCTTTACAGAATGTAAAAGTAATGATGAACATAATAGGCCCTCAACCGAAAATGCCTGTACAAATCAAAATCATGATACAAGCCGAATTCGACGCGCAGTTTGGATTTGTGATCAATGTGGCAAGCATTTTAAGGATTCGCAGGGGTTTAAATTCCATATGCTTCGACACACCGGAAACAAACAATTCGCATGCAATTTATGTGACACTAAATTTTACCAAAATCATATGCTCCAGTTACACATACTCACAGTTCATAAGGGCGAAAGACCATTTGTTTGCCGATACGAAAACTGTGATAGGAAGTTTAAAGCAGTGTCTACAAGACTTGTTCATGAAAGaACGCATACTTGTGATTATCCGTACAAATgtcattattgttttaaaaaatttaacaaaaaatcatcTCTAACAGCCCACCAAAGAGTGCATACGGGGGAGCGGCCATACAAGTGCCATTTGTGTGAGCAAAAATTTAAGCAGAAAAACACACTGAAAGAGCATCAACGTACACATAATCCAGAGGCAGTACCCCCGAGACGACAGTATAGGCGTGATTGTGATCATTGTGGGCAAACTTTTAATAGtgcatataattataaaatccACATACTACGTATGGCTGGAGACAAGCGATTCCCATGTAATCTATGTGATCGAAAATGCTACACAAATTATATGCTTCAATTACACATAAGAATTGCTCACGCGGGCGAGAGACCTTTTCCTTGTCGATATGAAAACTGCGCTAAGAAATTCAACGACACCTCTACGAGACGTTGTCATGAAAGaacGCATTCACAACTTTATCCTTTTCGTTGTTTGTACTGCAATAAGGGCTTTAACAAGGTAGCGCAGTGCAATGCCCACCAAAGTAGGCATCCAGAACAAGCTAACAATTAG
Protein Sequence
MASKPSCRTCGGCKYKGKAKPLFKNEAGNEILNYIKIITGLGLDDLPNMPGHICMTCEYHLDQAISFRERCIRTHEIFSSINIQSGKNSEENLTILSIFDKTDLNYHSNSIEEEHENNGTISQPLIDKSCVIVLDQKDVPEENCVTPNKQLEAKSSKHQNRPVYPYKCLYCEKQFKSTIIRAKHHRAHAGERQYKCKLCNMSFEQARYLKGHIDSEGHQNKMAAGNSILINNQNTSTNNRNKFCANPPIEYNDVNNSNRFDNAFEIFLKTDQTQNDETNNLAAVDPIATACEIVKAPVKNDQQYNLDEEQSNEASADFENVMCERAQMGKNRYKCKYCDKRFSKPSNCRAHERVHTGERPFQCENCDVSFKWKQSLKRHINSLGHQNNEGFRDDETKCKRNHKNTEHKEVCIHDTEGEEKSTSLQKLLEFSTGKEENTCKTVSKVDQQSVENNRCFEEHEDINAATLDPTDNVHESNSAISLLEGAVLERAEEGGIRYNCKYCGKRFTKPSNCRAHERVHTGERPFICEICDVSFKWKQSLQRHINSLEHQNNKSFSSENTVKCNKNYENTEHKRIMEFRADYTKREDKCTSEPKPQEADMESQECSSKAEDNNELLLTASLSKFICGNEDCNIEFKSNLSRVFHERTHKGELRYKCKYCDKRFDKSSNCREHYRVHTGERPFKCDICEVSYKWSQHLKRHIKSLEHLNKKNATLNPIDNAQLSSFTECKSNDEHNRPSTENACTNQNHDTSRIRRAVWICDQCGKHFKDSQGFKFHMLRHTGNKQFACNLCDTKFYQNHMLQLHILTVHKGERPFVCRYENCDRKFKAVSTRLVHERTHTCDYPYKCHYCFKKFNKKSSLTAHQRVHTGERPYKCHLCEQKFKQKNTLKEHQRTHNPEAVPPRRQYRRDCDHCGQTFNSAYNYKIHILRMAGDKRFPCNLCDRKCYTNYMLQLHIRIAHAGERPFPCRYENCAKKFNDTSTRRCHERTHSQLYPFRCLYCNKGFNKVAQCNAHQSRHPEQANN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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