Basic Information

Gene Symbol
gtf3a
Assembly
GCA_905146935.1
Location
LR989929.1:75130781-75132160[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 7.6e-06 0.00098 20.3 1.2 3 23 192 212 192 212 0.99
2 9 9e-06 0.0012 20.0 2.0 1 23 218 241 218 241 0.97
3 9 0.015 1.9 9.9 1.2 1 23 249 274 249 274 0.94
4 9 5.7e-05 0.0074 17.5 0.2 1 23 285 307 285 307 0.95
5 9 7.4e-06 0.00096 20.3 3.5 1 23 314 336 314 336 0.98
6 9 0.00098 0.13 13.6 1.5 1 23 342 364 342 364 0.97
7 9 0.0002 0.026 15.8 0.4 1 23 370 393 370 393 0.97
8 9 0.00019 0.024 15.9 2.2 1 23 399 421 399 421 0.96
9 9 6.4e-06 0.00084 20.5 3.4 1 23 427 449 427 449 0.97

Sequence Information

Coding Sequence
ATGGAACAATTCCAGCATTTGCACAATTTAAATATCCATTCCTCATGCAGGGCATGTCTGGAAAATTTAAATGACATGCATCACAATATATTCGAAGTACCAGACCTGCAAAAAAAATTGACTGTATGCATATCTCTGCCCGTGGAACCAGGAGACGGCTTTCCGACAAGTCTTTGTGAACCATGCCATGCCAAGATAGATGACTTCTATGATTTCCATCAAATGTGCATTTCAGCCAGACAAAAATTTCAGGACTTTATAAATTCTGAGAAAAAACCATGTACGTTGCAGTTAAGTTTGGATCCAGGCAATTTACCAACAACTGACTTAATGATGTTTAAGAAGGAAGCAAAAAAAGAGCAAGAAGATGAGTGTTTAAAATTCGACGCGGTAGAGCTTCCAATTCCGAATGTGAAAACCCAACATGATTCCTCATCGCAAGACGAAGAGGAGTCAGAAGATGACCAGCTAGACATAAAATATCATGTAAGTGACGAGGACAGTCAATTGATTGAAAACGATGAAAAATCTAAAGAAAATGCTACGAAAGCCTCTCCTGACAATGTCTTGGGTTGTAAAATCTGTAAGAAAACTTTTAAAAAAGAGGAGACATTTGCCGCTCACATGCGCGTACATGCAGGTCTAAAACCTTTTCCTTGTCAAAAATGCGACAAATCATACGCCCGACGAAGTAGACTTAAATTACACGTAAAAACCAAACATGACGGAGTACCTACCGAAAAATTTCCTTGCACGGAGCAGGGTTGTGATAGAATCATGTGTTCTAAGCAAACTCTACGAAAACATATCAAAGACATTCACTACAGCACTGGTGTGAAAACAAAGCAGCCCTATATATGTGAAGAGTGTGGAAAAGTCCTAACAAGTCTTGCCACGCTGAAAAATCACCGATTCTTACACACCGGTCAGCAACTTCCGCATGAATGTCCACAGTGCAATAAGAGATACATCACAAAGAACAAACTAAAAGAACACATGAACAGACACGCTGGCATCCGAAACTACATTTGTCCTCATTGTGGTGCTAAGAAATCAACACGCACCGAATTGAAAACCCATATAAACTATCACACCAAAGAAAAGACCTATCCGTGCCAGTTCTGCGGTAGTGTGTTTAACAGTATTGGGAATTTTAGTCGACACAAACGCATCGTTCATGAGGGCATAAAAGACTACCCATGTTCGTATTGTGATAAGTCTTTTGGCAAAGCCGAGACTAGGAAGCATCACGAAATGACTCACACTGGAGAGAAGCCCCACGAATGTAATATTTGTCACAAAAAGTTCATTCAACCTGTCGCCCTTAAAAAGCATAAAAAGATTCATCTTAAGGCAATGGCAGGGCAACCAGATTGGTAA
Protein Sequence
MEQFQHLHNLNIHSSCRACLENLNDMHHNIFEVPDLQKKLTVCISLPVEPGDGFPTSLCEPCHAKIDDFYDFHQMCISARQKFQDFINSEKKPCTLQLSLDPGNLPTTDLMMFKKEAKKEQEDECLKFDAVELPIPNVKTQHDSSSQDEEESEDDQLDIKYHVSDEDSQLIENDEKSKENATKASPDNVLGCKICKKTFKKEETFAAHMRVHAGLKPFPCQKCDKSYARRSRLKLHVKTKHDGVPTEKFPCTEQGCDRIMCSKQTLRKHIKDIHYSTGVKTKQPYICEECGKVLTSLATLKNHRFLHTGQQLPHECPQCNKRYITKNKLKEHMNRHAGIRNYICPHCGAKKSTRTELKTHINYHTKEKTYPCQFCGSVFNSIGNFSRHKRIVHEGIKDYPCSYCDKSFGKAETRKHHEMTHTGEKPHECNICHKKFIQPVALKKHKKIHLKAMAGQPDW

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00694065;
90% Identity
-
80% Identity
-