Basic Information

Gene Symbol
ZEB2
Assembly
GCA_947532125.1
Location
OX383923.1:5902995-5921886[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00058 0.032 15.0 3.2 1 23 329 351 329 351 0.98
2 10 4.3 2.3e+02 2.8 4.2 2 21 356 375 355 377 0.92
3 10 0.69 38 5.3 2.5 2 23 381 403 374 403 0.83
4 10 0.0088 0.48 11.3 8.0 1 21 406 426 406 428 0.95
5 10 0.021 1.1 10.1 4.9 2 23 433 455 433 455 0.94
6 10 3.8 2.1e+02 3.0 0.1 6 21 468 483 464 488 0.87
7 10 0.0011 0.062 14.1 0.1 2 23 501 523 500 523 0.95
8 10 0.095 5.2 8.0 1.6 1 23 529 552 529 552 0.89
9 10 3.7e-05 0.002 18.8 0.5 2 23 562 583 561 583 0.97
10 10 0.00051 0.028 15.2 5.1 1 23 589 612 589 612 0.96

Sequence Information

Coding Sequence
ATGTCGAAAGAAAGAAAAAAACAGTATACGATTGAGGGCACACCTCCAACAAGTGTTCGAGAAAATAATGCAAATCTCGTTCCTCAACAGAATCCATTAGAATGGTCATCTCACCAAGTGCAAGAGAAACCTAACACAAACTGCAAATTGTGTCAAAAAAAAAACGATTTGATAAATAAACTGCGCTATATTCACAAGAAGGAGATAGACAGAACTCTTTCAACTTTAGGCGAATATAATGATATTTATGTGAAAATTTGTGAAAATTCCTGCGCAATTCCACAAAAACAAATATATTTATGTTGGGAGTGCATGGCCTTGTTAAATAGAATAAAACAGTTCAAGAAAAAAGTGGATTTAGCTCAGAAACATTTAAAATTGTGTTGGATTAATAAGAAAGATCCATATCCATCTTTATCGAACTTAACTAAAACACGAAATGAAACCATAGTATACTTAAGGTATGAAGAAGAATTTAAACCTTTGTATGAAGAAGAATTTAAACCTTTAGAAATTAAAATAGAAACTGATGTCAGCTCTATACTGGATGTTGATTATGATAATACTCCATGTCTAGATAATATTAAACAAGAATTAGAAATAGTTAAAGAAGAAATAGAAATAGTTAAAGAAGAATTAGAAATAGTTAAAGAAGATTGTGATGAACAGACTCAGGCGAACACAAATGAGATAATAGACACAAAAGTAAACGTAAAATGTGAAATTGAAGGATCAATACAAACAGGAAATATTGAAAGCAAACCCACGTCAGGTGTGAAACATTACAGGTGGATGTATACTGTACCAAGGAAAGAATTGATAAAGAAAATTCCAATTGCATTCAGTGATGTTAAACCTTTGATGATGAGTGATAATATAAATAAATGTTATAGTTATAAATGTGATAATTGTGTTGATGGGTGGAAATCCCATAGAAAACTTATTGATCACATGGCAAAATTTCACAATGAgAATAACAAACAGTACATTTGTGATATATGCTCATCATCTTTCAATGGAAAGTGTTCACTAAAAAAACATATAAAAAAACACAGCTATATGCAGGAATGTGGTGTGTGCGGGCACCGATGCTATAATTATAAGTTGATGAGATCCCACGTCAAATGTCACAAACAAGTAAAATGTATCTATTGCGGCTTGATTACAAAGAATCGATTTATGTTTTACAAGCACTATAATTCTGAGCACGGCTGCTTCATCTGCGACCATTGCGGGAAGAAATGCAAGACTAGATACATGATTGAAAAACATATGAGATGTCACTACGCGATAAATGAATGCGAGGTCTGTCACATGCGGTTCAAGACCAAGTCGATACTGCGCAGGCACCACGACATGAAGCACGCGGTCACTCGCACGGAGAACGAGTACTGCGCGCCCTGCAACCGCCAGTTCGAAACGGTCGCCGCGTACCGCCATCACGTGCAGGTCTCCGTCGCGCACGCGCACGAGAGGAAAGTCAGAATAAAGAAGAAAGTGCCATGCCCTGATTGCGGAATCCTGTACACGAAGAGATCCTATATGATGAACCATTACAGATATGTCCACATAAAACAGTCCAAATATTACTGCACGGAATGTGACAAGCCTTTTTTGAATCGAACCCGATACGTGGATCACGTGAAGTACAAACACGAGGGCATGAAAAAGGAGAAGAACAAAGTATGCAATATTTGCGGCAAAGGCTTCACGGACAATAGGATATTGGAAAATCACACAAGGACGCATTCCGGCGAGCGGCCCTTCGAGTGTCCCCACTGTACCCGCAGGTTCACACAGAAATACTCAATGCTCTCCCATGTCAAACATATACATCAGAAGATCGAAGGGAAGTTGGGCTGA
Protein Sequence
MSKERKKQYTIEGTPPTSVRENNANLVPQQNPLEWSSHQVQEKPNTNCKLCQKKNDLINKLRYIHKKEIDRTLSTLGEYNDIYVKICENSCAIPQKQIYLCWECMALLNRIKQFKKKVDLAQKHLKLCWINKKDPYPSLSNLTKTRNETIVYLRYEEEFKPLYEEEFKPLEIKIETDVSSILDVDYDNTPCLDNIKQELEIVKEEIEIVKEELEIVKEDCDEQTQANTNEIIDTKVNVKCEIEGSIQTGNIESKPTSGVKHYRWMYTVPRKELIKKIPIAFSDVKPLMMSDNINKCYSYKCDNCVDGWKSHRKLIDHMAKFHNENNKQYICDICSSSFNGKCSLKKHIKKHSYMQECGVCGHRCYNYKLMRSHVKCHKQVKCIYCGLITKNRFMFYKHYNSEHGCFICDHCGKKCKTRYMIEKHMRCHYAINECEVCHMRFKTKSILRRHHDMKHAVTRTENEYCAPCNRQFETVAAYRHHVQVSVAHAHERKVRIKKKVPCPDCGILYTKRSYMMNHYRYVHIKQSKYYCTECDKPFLNRTRYVDHVKYKHEGMKKEKNKVCNICGKGFTDNRILENHTRTHSGERPFECPHCTRRFTQKYSMLSHVKHIHQKIEGKLG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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