Basic Information

Gene Symbol
ZFY
Assembly
GCA_947532125.1
Location
OX383920.1:1908295-1914721[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.00023 0.012 16.3 0.8 2 23 161 182 160 182 0.95
2 14 1.6 88 4.1 0.0 7 20 205 218 205 222 0.87
3 14 0.00061 0.033 14.9 0.9 1 23 264 287 264 287 0.98
4 14 0.00022 0.012 16.3 1.2 6 23 298 316 296 316 0.95
5 14 0.00024 0.013 16.2 2.0 1 23 338 361 338 361 0.97
6 14 0.0015 0.082 13.7 3.0 6 23 372 390 370 390 0.93
7 14 0.00012 0.0064 17.2 1.9 1 23 412 435 412 435 0.98
8 14 0.00036 0.02 15.6 3.6 6 23 446 464 444 464 0.96
9 14 0.018 0.97 10.3 2.0 1 23 486 509 486 509 0.96
10 14 0.0029 0.16 12.8 2.1 6 23 520 538 518 538 0.94
11 14 0.0046 0.25 12.1 1.6 1 23 560 583 560 583 0.98
12 14 0.00019 0.01 16.5 1.2 6 23 594 612 592 612 0.95
13 14 0.0004 0.022 15.5 1.2 1 23 634 657 634 657 0.98
14 14 0.043 2.4 9.1 0.6 6 23 668 686 666 686 0.95

Sequence Information

Coding Sequence
ATGGATAACAAGGAACATCCAGCAATCAGTTGTGAAACATTGAGTAACACAGCTCCAGAGGTACAGAGCAATCAACATATATGTGTGCCAACAATGAAAGTAGACATTAAAGAAGAAACAAAATCAGAAAGCAGAGATGAAGAAGAGTCACCTTGCAGTGACTTTAAGTATCCACCAGAGCTCCTGGAGACATCTGAGTTTGTGAATTACTATGACAATAAGGAATATGCATTGGAACAACTGAAGAAAGAATTCCCTGAGGATGAATGTCTTAACATGGAATTATCAAAACTTATAGACGAACAACAAGTAAAACATGAAAATTCAGAGGATGGACTGTCATTACTAATAAACGAAGAAAATGTCAATAAAAAGAACCAGATTACAGTAAAAATGGAGAGGCTAAAAGAACAAGATATATTGTATAATGCTGAAGCAACTAGCATACATTATGATGTCCTGGTAACTCGTCGAGTAGTTCAATGCAAGTTGTGCGGTCGAATATTCAAAAACAGTTTCAGTTTATTAAATCACAATAATGAACACATAAAAGTTGAAATAAACACATCAGAGGATAAAGAAATGATTGAGTTACACCATTTCCAATATTACGACAAAGTTTTCAAAAATAGCGATAATATGCTTGCACATGTCGGTGATGTTCACAGCCAGAAAAAACCTAAAGACAAATTATGCAGAAAACAATTACCCAGCACCATGCACCCTGATGGTAACATTAATGGTACAAATAATAACAAACTTACTGGTAAAAAGGTTGAAAAAAAGAAATATAAATGTGACTCATGTGAAGGTACTTATAAAAGTAAAGGTTCTTTAACCCTGCATATAAAGAGGATGCATTATGATCACGGGAGAACGTTTGCATGTTGGTGCGGGAAAGAGTTCCGTACACCGATACACTTACGTATACATATGAATCGGCAGCATGATGGTCACATAAATGGTACAAATAATGACAAACTTGCTGGTAACGTTGTTAAAAAAATGAAATATAAATGTGACTCATGTGAAGGCACTTTTAAAAGTAAAGATTATTTAAGAAGTCATATAAAGAACAAGCATTATGATTACGGGAGAATGTTTGAATGTTGGTGCGGGAAAAAGTTCCGTACACCGCATCTTTTACGTACGCATATGATTCATGTGCATGATGGTAACATTAATGGTACAAATAATGACAAACTGACTGGTAAGGTGGTTGGGGAAATGAAATATAAATGTGACTCATGTGATGGTACTTATAAAAGTAAATATTATTTAACTCAGCATATAAAGAGGATACACTATAATCACGGGAGAACGTTTGCATGTAGGTGCGGGAAAGAGTTCCGTACACCGCAACATTTACGTACGCATATGAAGAAACAGCATGATGGTTACATGAATATTACAAATAATGATAAACTTACTGGTAAGGAGGTTGAGAAAATGAAATATAAATGTGACTCATGTGAAGGTACTTATAAAAGTAAACATTATTTAGGAATTCATATAAGGGACAAGCATTATGATTACGGGAGAACGTTTGCATGTTGGTGTGGGAAACAGTTCCGTACACCGCATCGTTTACGTACGCATATGAATCAGGTGCATGATGGTAACATTAATGGTACAAATAATGATAAACTGACTGGTAAGGAGGTTGAGAAAATGAAATATAAATGTGACTCATGTGAAGGTACTTTTGAAATTAAACAGTATTTAACTCGGCATATAAAGAGAAAGCATTATGATCACGGGAGAACGTTTGCATGTTGGTGCGGGAAAGAGTTCCGTACACCGATACACTTACGTGTGCATATGAATCGGCAGCATGATGATAACATAAATGGTACAAATAATGACAAACTTACTGGTAAGGGGGTTGAGAAAATGAAATATAAATGTGACTCATGTGAAGGTACTTATAAATATAAAGTTTCTTTGACTCGGCATATAAAGATGATGCATTATGATTACGGGAGAACGTTTGCATGTTGGTGCGGGGAACAGTTCCGTTCACCGTTACAGTTACGTGATCATAAGAAGCGGCAGCATTGTGGCAAAATTAAAGATATAGATAACAACAAAGTTCTATCACATATCTTGTTCATCGATTGA
Protein Sequence
MDNKEHPAISCETLSNTAPEVQSNQHICVPTMKVDIKEETKSESRDEEESPCSDFKYPPELLETSEFVNYYDNKEYALEQLKKEFPEDECLNMELSKLIDEQQVKHENSEDGLSLLINEENVNKKNQITVKMERLKEQDILYNAEATSIHYDVLVTRRVVQCKLCGRIFKNSFSLLNHNNEHIKVEINTSEDKEMIELHHFQYYDKVFKNSDNMLAHVGDVHSQKKPKDKLCRKQLPSTMHPDGNINGTNNNKLTGKKVEKKKYKCDSCEGTYKSKGSLTLHIKRMHYDHGRTFACWCGKEFRTPIHLRIHMNRQHDGHINGTNNDKLAGNVVKKMKYKCDSCEGTFKSKDYLRSHIKNKHYDYGRMFECWCGKKFRTPHLLRTHMIHVHDGNINGTNNDKLTGKVVGEMKYKCDSCDGTYKSKYYLTQHIKRIHYNHGRTFACRCGKEFRTPQHLRTHMKKQHDGYMNITNNDKLTGKEVEKMKYKCDSCEGTYKSKHYLGIHIRDKHYDYGRTFACWCGKQFRTPHRLRTHMNQVHDGNINGTNNDKLTGKEVEKMKYKCDSCEGTFEIKQYLTRHIKRKHYDHGRTFACWCGKEFRTPIHLRVHMNRQHDDNINGTNNDKLTGKGVEKMKYKCDSCEGTYKYKVSLTRHIKMMHYDYGRTFACWCGEQFRSPLQLRDHKKRQHCGKIKDIDNNKVLSHILFID

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
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80% Identity
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