Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.00053 0.042 14.9 0.6 1 23 29 52 29 52 0.97

2 5 8.3e-06 0.00066 20.6 1.8 1 23 169 191 169 191 0.98

3 5 0.0011 0.085 14.0 3.0 1 23 197 219 197 219 0.96

4 5 0.0062 0.5 11.6 0.3 1 23 225 248 225 248 0.95

5 5 0.0003 0.024 15.7 3.8 1 23 285 308 285 308 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.00053	0.042	14.9	0.6	1	23	29	52	29	52	0.97
2	5	8.3e-06	0.00066	20.6	1.8	1	23	169	191	169	191	0.98
3	5	0.0011	0.085	14.0	3.0	1	23	197	219	197	219	0.96
4	5	0.0062	0.5	11.6	0.3	1	23	225	248	225	248	0.95
5	5	0.0003	0.024	15.7	3.8	1	23	285	308	285	308	0.98

Coding Sequence: atgttaaattttcctttaacacCAGGCGATAAATATGAAGGACGTTGTGCTGAAATATATATAACTGAAAAACAATTCCTGGTCTATCATTGTTCGGTATGTGATGAAATCTATGCCACATTCAATGACCTCTTAAGCCACATAAACAAAGACCACTATGAAAATACCAAAGAATACCAAGAAGGGGAAGCAACAAGTAGTGTTGCAACAAACACTAACAATTTACAACACCACCCAAATGAAAACCagtttattataaaagaattaaaaataactaaTAACGACTTGGCCTATTGCAACGGCCTAAAAAAAGAAACGACTAACAAGAATCCAGCATTAAAAGTTCACGATAATGCAACTGCTGTTTTGGATAATAAAAATACTCCTCAAAGAAAAAAACCGCGAATGGTgtcaagtattttaaaatattatgctGCTATGAatagaacaaaattaaatgttttaatacgtgatcaattaaaaaatgatCAAGAAGAAAGTAAATATGTGTGTGGTCAATGTGGTTTTGCTTTTAAGGAAAAGCATAATTTACGCAGTCATCTTTTAAGACATTCCAATCAAAAGAATTTTAGCTGTTCCTTatgtttgaaaaagtttttcaccaAAAGCGAATTACGCTTGCACGAGTATCGCCACAAAGCAGAGCGTCCCTATCTATGCAAGAATTGTGGCATGGGCTTTTTAAGTGCAAATTCTCTAAGTCAGCACCTAAGGAATCTCCATAGCCAACAATTGTCGAAGGAACGTGAGCTGGAGAATCAACTGACGACACAAAATCAATGTCAAGATGACAATGATTTAAAACTTAATGGTCAAGCTAATACGAAATTTTACCGTTGtggttattgtaatttaaagtaTGACAAAAAGTATGATTTAAAAAGTCACTATAAAAAGCAACACGACTGCAACAAAACCGTAATGAAAGACGTTAATAAAATCTACTCGCCAGAAGGATCTAAATTAAGTTTAATAGAAACTGTGGATGAATACGAATTGGTACAAACTTTAACAGATTTAGagtgtaatgaaaaataa
Protein Sequence: MLNFPLTPGDKYEGRCAEIYITEKQFLVYHCSVCDEIYATFNDLLSHINKDHYENTKEYQEGEATSSVATNTNNLQHHPNENQFIIKELKITNNDLAYCNGLKKETTNKNPALKVHDNATAVLDNKNTPQRKKPRMVSSILKYYAAMNRTKLNVLIRDQLKNDQEESKYVCGQCGFAFKEKHNLRSHLLRHSNQKNFSCSLCLKKFFTKSELRLHEYRHKAERPYLCKNCGMGFLSANSLSQHLRNLHSQQLSKERELENQLTTQNQCQDDNDLKLNGQANTKFYRCGYCNLKYDKKYDLKSHYKKQHDCNKTVMKDVNKIYSPEGSKLSLIETVDEYELVQTLTDLECNEK*

Sequence clustering based on sequence similarity using MMseqs2