Basic Information

Gene Symbol
-
Assembly
GCA_028565995.1
Location
JAOWBB010006726.1:707-3518[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 1.4 2.5e+02 3.4 0.3 3 23 30 49 29 49 0.72
2 20 3.2 5.4e+02 2.3 3.3 1 19 55 73 55 78 0.73
3 20 0.00023 0.04 15.3 0.6 2 23 83 105 82 105 0.96
4 20 2.2 3.8e+02 2.8 0.4 1 23 110 134 110 134 0.85
5 20 0.00087 0.15 13.5 0.6 2 23 141 162 141 162 0.96
6 20 8.8e-05 0.015 16.7 4.1 1 23 168 191 168 191 0.95
7 20 1.9e-05 0.0032 18.8 1.6 1 23 197 219 197 219 0.93
8 20 0.00019 0.032 15.6 1.3 1 23 225 247 225 247 0.98
9 20 2.3e-05 0.004 18.5 4.2 1 23 253 275 253 275 0.98
10 20 3.3 5.6e+02 2.3 12.0 1 23 284 307 284 307 0.90
11 20 0.22 37 6.0 0.3 2 22 491 512 490 515 0.87
12 20 0.00029 0.049 15.0 3.9 1 23 515 538 515 538 0.93
13 20 2.3e-06 0.00039 21.7 1.3 1 23 542 564 542 564 0.98
14 20 0.00014 0.023 16.1 2.8 1 23 570 592 570 592 0.98
15 20 0.00063 0.11 14.0 2.9 2 23 599 620 597 620 0.94
16 20 0.00031 0.053 15.0 1.6 1 23 626 649 626 649 0.98
17 20 6.8e-05 0.012 17.0 1.3 1 23 657 680 657 680 0.95
18 20 0.00019 0.032 15.6 1.6 1 23 686 708 686 708 0.98
19 20 0.00056 0.095 14.2 0.3 1 23 714 736 714 736 0.97
20 20 0.03 5 8.7 2.9 1 23 741 763 741 763 0.99

Sequence Information

Coding Sequence
ATGTTTAGGACCGATGAGGGTAGTAGAGCCGGGAAAAAAGTAAGCTCCAGGGAAAAGAAGACCGCTTACTTTTCGAAAAGGGCCTCATGCGTTAAATGCGGCGAAAAATTCAAGATTCTGGACATGGCTTCTCATCTGAGAGACCACGAAACGAAACCTCTGCATCCGTGCGATCGCTGTGACAAAGTTTTCGTGTGCATCTACGCCTGGCATCGGCACGGATTCAAGCTTCACGGAAAGCAATTGCGGTGCAACGATTGCGGCAGGAGATACAACTACGTGGACAGATTCATAAGACACATACGCTACGGCCACGCTGAGAAGACATATGTGTGTACAGTTTGCAATAATTACTCTACGTCAATAAGTGCAAGATTGAGAAAGCACGTGGAGCAAACACACATGAAACAATATGTAGCCTATTGTGATATATGTTCTAAAGGATTTTTCGATAAGACATACTTGgaagaacataaaaatttacattcaggTGATACTCCTCATCAATGCGAGCTCTGCGGAAAAAGCTTTCGACTAAAAACCACTCTTCGAGCCCACcgttttaagtttcatttggAATTGTTTCCACACGTATGCCACATATGTAAAAAGGGATTCGCAACCAAATCCGGTTTAAAAGCTCATGAGGATCTGCATGCAGAGAATAGACAATATATATGCGACTTCTGTGGTAAACATTTAACGACTGTGGCCACTTTAACCGAGCATAGAAGAATGCACACGGGAGAATTTCCTTTCAAATGTGATCTCTGTGATAAAGCTTTCAGAGCAAAGAAACATTTGACTAGACACAAATCTTCCCATTCCGGTACCCATTTGGAGAAAAATCATGAATGCCATTACTGCgacaaaaagttttccaatGTAACTGCTTGTTTGCATCACACCCAAAAATGTCATGCCAGTTTTCTCGATCATTCGGTCAATCCGgtgctgtTGGCCGATTCACCAAAGATTGAGAACGATCTTTACGTGCAAGCCGTAGAGAAACCAAAaagaaacgagaaaaaaacaaagaattcaTCCGATAACAAAACCATGAAGCATTTGAtcccgaagaaaaaatatttcaatccgAAAAGCATCAAAAACAGTGAATCTGAAGAAATGGATTacgaagttaaattaaatatgttcaTAAAAGAAGAGCCGTATTCCTCAGACGATGACTTACCCTTGGCCACCAGAGCCAGGCAATTTTCGGACATCAACGAATCGgaatttcctttaataaaggtggaaaatataaaatctgatGATAACATTCCGGAGAAGCTTAACGATTCGagcaaagtgaaatttaagaagaaaaaaggagtgGACTGCGATTTATTACGTgaggaattgaaaaaatttggggaagacatggaaaaaaaactggagCAGATAATTATAGAAGCCCAAAAGAGTTTGGATACGAAATTGGGCAAATTCCCCCGAGAAAAAACGGAATGTCCACTATgcggggaaaaatatttcgaaattctCGGCCATCTCGAGCGACATGCTAAGAGAACTCCTCACAGTtgcaataaatgtaataaatcgTTCACCTTCAAGGGGAAATTAATGGACCACAAGAAATTTGCCCACGGAATCAGCTACGCTTGCGAGATATGCAATAAACGTTTCAATCACAGAGACAACATAAGGATTCATATGGCCACTCATGAAAcagaggaaaaatatatatgctaTTTATGCGGATATTCGACTAAACGCAAACAGTGCCTTGAAGTTCATATGATGCGCCACGAAGAAAAGTGGGTTTGCCACTGCTCCATCTGCAACCGAGGCTTTTTCTCGTATGCCACACTGGCTCAACACATGAACAGCCACACGGGTGAGAAACCCTACACTTGCGATCAGTGCGGCGCAAACTACACAAATTATAACACTCTTTGGAAGCATTCCCGAAAATTCCATCCCGAACAGTATAACAATCTTTTCAGTTGTAAAGTCTGTGGGAAGGTGTTTGTGAAGGAAAAATCGTATCATATTCACATGGCCAATCTTCATTCGAAGGGAAACCATTTCGAATGCGATTCCTGCACGAAGACGTTCAAGAAAGAGTTATCCCTGATAATACACAAGCGAACGCATACGAACGAGCGTCCGTACATATGCAAAATATGTTCTGGTGCCTTCACAGCCAGGAAATATCTAACAAAACATATGGGGGTTCACAAGGCTAAAAACTATAAGTGTCGCTTTTGCTACAAGAAATTCATGCTGGAGCAAGCTCTAATGACCCACGAACGAAAGCATGAGGAAGTTAGATGA
Protein Sequence
MFRTDEGSRAGKKVSSREKKTAYFSKRASCVKCGEKFKILDMASHLRDHETKPLHPCDRCDKVFVCIYAWHRHGFKLHGKQLRCNDCGRRYNYVDRFIRHIRYGHAEKTYVCTVCNNYSTSISARLRKHVEQTHMKQYVAYCDICSKGFFDKTYLEEHKNLHSGDTPHQCELCGKSFRLKTTLRAHRFKFHLELFPHVCHICKKGFATKSGLKAHEDLHAENRQYICDFCGKHLTTVATLTEHRRMHTGEFPFKCDLCDKAFRAKKHLTRHKSSHSGTHLEKNHECHYCDKKFSNVTACLHHTQKCHASFLDHSVNPVLLADSPKIENDLYVQAVEKPKRNEKKTKNSSDNKTMKHLIPKKKYFNPKSIKNSESEEMDYEVKLNMFIKEEPYSSDDDLPLATRARQFSDINESEFPLIKVENIKSDDNIPEKLNDSSKVKFKKKKGVDCDLLREELKKFGEDMEKKLEQIIIEAQKSLDTKLGKFPREKTECPLCGEKYFEILGHLERHAKRTPHSCNKCNKSFTFKGKLMDHKKFAHGISYACEICNKRFNHRDNIRIHMATHETEEKYICYLCGYSTKRKQCLEVHMMRHEEKWVCHCSICNRGFFSYATLAQHMNSHTGEKPYTCDQCGANYTNYNTLWKHSRKFHPEQYNNLFSCKVCGKVFVKEKSYHIHMANLHSKGNHFECDSCTKTFKKELSLIIHKRTHTNERPYICKICSGAFTARKYLTKHMGVHKAKNYKCRFCYKKFMLEQALMTHERKHEEVR

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-