Basic Information

Gene Symbol
ush
Assembly
GCA_949824845.1
Location
OX463755.1:31923417-31927300[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.092 12 7.3 0.1 1 20 181 200 181 202 0.89
2 9 0.00024 0.031 15.4 0.8 1 23 247 269 247 269 0.98
3 9 0.026 3.3 9.1 1.0 2 21 294 313 294 314 0.92
4 9 0.042 5.3 8.4 2.9 2 21 683 702 682 703 0.93
5 9 0.0076 0.96 10.8 0.0 3 21 740 758 738 759 0.92
6 9 4.4 5.5e+02 2.1 0.1 1 23 804 826 804 826 0.65
7 9 0.012 1.5 10.1 1.3 1 23 832 854 832 854 0.99
8 9 0.00016 0.02 16.0 0.6 1 23 925 948 925 948 0.96
9 9 0.21 26 6.2 1.4 2 20 1082 1100 1081 1102 0.91

Sequence Information

Coding Sequence
ATGAGCGTTTTAGATATTCACACGATCAACTGTTCCCAATTCTATCTATTTCCAGAAACAAAAGAACTTAGTCCAAGCGATTTGAATGAACAAGCCGATGCGGTTTCGTCTGCGGACATTGATCTATCAGCCGAAGCACGAACGCCGTTTACAACAGAATCACTAATGGACGATAATCGCCCGTCTTCGAGTACACCCCGGACACTATCACCGCCCTCCGATCCGGAAGCAGATGATCATCGATCGCCTTCGGTAAGATCTGATCTACAGTCGGCGGCGAATTCACCTTCCGATGAGCATGATGAAGTATTGATAGTTCCTGCTGTTGCTGCGATTCCTAAGCTGCGGCTAAATGCACTTCTAGCCTCTGATCCCGCCCTGAATCCGGATgcgagaaatttaaaaattcttcatGAAGAGTCCACCAAGAATCACCATCACGAGGAATCGGATAGTGCAACACCCACACCAGTAGGTGAGCAGAAGACAAAAAGCCAAACATCAGCTGTTGTTGTGGACAATACGCAACGAGTGAAGGTGTTTATGTGTCTTCCCTGCAGTATTGGGTTCTCGTCGAGATCGACGCTGGAAGCACATCAGGCGTACTACTGTTCCCACAGAAAAGAAGTTGAAGAAGATCCAGCAGGAGGAGGCGCTGGAAGCGTCTCATCTGGAGATAAAAATTCCACCATAATCTCTGGTGAACCATCAGCGAAATCCATTAAGACTGGCAAGCAATACGCTTGCACACAGTGCTCCTACAGTGCCGACAAGAAGGTCTCGTTAAATCGGCACATGCGAATGCACCAAAGTTCACCGGCTCCAAGTTCGAACGCCTCGAACGGTGGCGATGATAGTTCTAGTCAACAAGTCGATCGTTACTGCTCTGAATGTGATATTAGATTCTCGAATGTTAAGACATATCGGGCGCATAAGCAACACTATTGTAGTTCCAGACGCAATGATGGGCAAACAACACCAAAACTTCCAGAGCCCAGCTTAAAGTCTAGTGGCGGTTCCGTAAGTCCACCGCAAGTCCGAACGAAAACACCGACTCCAGCTGCAGTAGTTGCAGCTGCAGCGGCAGCCGCAGCAGCAGCCGTAACTCCGCAACCATTCATTGCTCTACCGACAAATCCCATTCTTATTATTCCCTACTACCTTATACGAGCGGCCAGCATGATACCTGGACCATTAACGTCAGTATCGTCTGGAATAACGAATCCCGAAAGCACATGTTTCTCATTAGAAAACGGATCTCTCAAGCCAATGGCGACCGCCTTAAGCACCAGCAGCATTACGAACAACCAAATTCCACACGTGGACTCAACCCCACGATCACATCCTCCACCGCCAACCACTCCTTCGAATAATGAGACCGTAGTAGCATCATCTACGCCACTCCTGATGGAAAAAAACACACGTGCAGCATCTGTAAATAGTTGCAATGACTCTACAAAGCCTGGCAAAAAAGAAGGCGTTCGAGACTTTGCGCCGTTAGATCTTTCTCTCAGACGCTCGCCCATTCAGAGAGCTCAGCGTGTTCGATCATCTTCGAGTTTCTTGCAGCCCGTTGACGATAGAATCGATATCGAAACAATGATGGAGGGAAAGGAGAACCTATCCATCGACAGTGGCAGTATGACTCCTGAGCAAATTGTCTGCGCTCCATCATTACCCAACAGTCCCTCCATGAGTCCCTCGCCGAAACGACGCGCACTCAGTCCACGAAGCAGCAGTGCAGCTTCAATGTCCCCCGTACCGCCATCGGTTATGGACCACCTACCGTTGAGATCGATTCTACCCGCTGACATCGCCATGAAACTGACCGAGTCGAATATAATTCCACCGCTCATTGCCAAACAAAATCTGGAGCTGGCCTTCAAGTTGTCATCTGCGTCCGCAGCTGCAGCTGCCGTAGCAGCGGCGAACAGTAAGCAAAACGACGCGAACAAGGCGACGATGGGTAATCCCCTACTGGCGCCGATAAACGTGGGAGCAACATCCAGCGGCCAGCCACAGATCTTCGTCAAACAAGGCGTTTCCAAGTGTAAGGAATGCAACATCGTATTCTGCAAGTACGAGAACTACTTGGCCCACAAACAGCACTACTGTTCGGCTAGGAATCAAGAAGACACCGAGAACAAGACCAGTACTTCTCCGTCGGCATCGAATGCCGGTGTTGAGACTAATCCAATTGCCTATCAGCAGTTAATCTGTGCAGCCTGTGGCATCAAATACACTTCACTGGACAACTTGAGGGCTCATCAAAAGTTCTACTGTCCAAAGGGAGGTGGCGACGCCTCCGCAGCACCGCCAGTTACAAAAGAGAAATGTGCAAAGTGCAAGACGCTTCATGAAATTGGCCAGCCCTGCCCACCAATAGCTGCAGCCGCGCAACAAGGTTCCTACAAGTGTCCCGTATGTGAAGTAATCAGTCTAACGGCCGCCGAGAGTCGAAAGCATCTTGAAACGCACGGTAGTGTGAAGGCGTTTCGCTGTTCCATCTGTCGATACAAGGGGAACACGCTGCGTGGTATGAGGACGCACATTCGGATGCACTTCGACAAGAAGACTTCAGACTTCAACGAGGAGAACTACATGTCATGCATTCTGGAAGATGATGGATTGGAGATACCAAGCCCTGCGTctctcagccaagaacaagCAGCACAATTCGCTCAACAGCAACATATTCTtctgcaacagcagcaacaacaacagcagtcaTCCACACAGCAACAGCATTCGCCACAACAGCCACAACAGATATTCAACTGCGAGATCTGCAACTACTCATCCTCCTACAAAGGCAATGTGatgCGCCACATGAAGCTGGTTCACTCACAACCTGGAACATCGCCCTCCATTTCCCCCGAAATGATGATGGAGGAAGGGGAACCCACCAACACTCTCAGTCTTAACGGCGACAATGGCAACAGCCTTCCCGACGGTTTTACCATAAAAACGGAACCACTCGAACCAACCGCCACTATCATCAccaaaaacaataacaactcCACCCCcaatcatcaccatcatcatcatcatcatctggaCTCACTCACACAGATCAAATCAGAACCTATGGAGACGGCAGACAGTGTCATTCGAACACTTCCATCACCCTTGGCAGTGCCACCGCCACCGCTTAACTCATCATCGCCCCTGTCGGGTGATGAGAATTCATTATTGAGGAATTCCACGTCGATTGGATCGAGCGGAATGCCCTTCAACCAGAAGTACTGTCACACATGCGACATCAGCTTCAACTATATGAAGACCTACCTAGCGCATAAGCAGTTCTATTGTAAGAATAAACCTCAAGGTGACGGCGATAGTACGAGTCCAGTACCGCCAGTGCAATCGCCAACAATGTTGAATAAGAACAAGGAAAACCTGGAAGCAGCTTTGTTATAG
Protein Sequence
MSVLDIHTINCSQFYLFPETKELSPSDLNEQADAVSSADIDLSAEARTPFTTESLMDDNRPSSSTPRTLSPPSDPEADDHRSPSVRSDLQSAANSPSDEHDEVLIVPAVAAIPKLRLNALLASDPALNPDARNLKILHEESTKNHHHEESDSATPTPVGEQKTKSQTSAVVVDNTQRVKVFMCLPCSIGFSSRSTLEAHQAYYCSHRKEVEEDPAGGGAGSVSSGDKNSTIISGEPSAKSIKTGKQYACTQCSYSADKKVSLNRHMRMHQSSPAPSSNASNGGDDSSSQQVDRYCSECDIRFSNVKTYRAHKQHYCSSRRNDGQTTPKLPEPSLKSSGGSVSPPQVRTKTPTPAAVVAAAAAAAAAAVTPQPFIALPTNPILIIPYYLIRAASMIPGPLTSVSSGITNPESTCFSLENGSLKPMATALSTSSITNNQIPHVDSTPRSHPPPPTTPSNNETVVASSTPLLMEKNTRAASVNSCNDSTKPGKKEGVRDFAPLDLSLRRSPIQRAQRVRSSSSFLQPVDDRIDIETMMEGKENLSIDSGSMTPEQIVCAPSLPNSPSMSPSPKRRALSPRSSSAASMSPVPPSVMDHLPLRSILPADIAMKLTESNIIPPLIAKQNLELAFKLSSASAAAAAVAAANSKQNDANKATMGNPLLAPINVGATSSGQPQIFVKQGVSKCKECNIVFCKYENYLAHKQHYCSARNQEDTENKTSTSPSASNAGVETNPIAYQQLICAACGIKYTSLDNLRAHQKFYCPKGGGDASAAPPVTKEKCAKCKTLHEIGQPCPPIAAAAQQGSYKCPVCEVISLTAAESRKHLETHGSVKAFRCSICRYKGNTLRGMRTHIRMHFDKKTSDFNEENYMSCILEDDGLEIPSPASLSQEQAAQFAQQQHILLQQQQQQQQSSTQQQHSPQQPQQIFNCEICNYSSSYKGNVMRHMKLVHSQPGTSPSISPEMMMEEGEPTNTLSLNGDNGNSLPDGFTIKTEPLEPTATIITKNNNNSTPNHHHHHHHHLDSLTQIKSEPMETADSVIRTLPSPLAVPPPPLNSSSPLSGDENSLLRNSTSIGSSGMPFNQKYCHTCDISFNYMKTYLAHKQFYCKNKPQGDGDSTSPVPPVQSPTMLNKNKENLEAALL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01223805;
90% Identity
iTF_01300393;
80% Identity
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