Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.00063 0.13 14.8 0.6 2 23 107 129 106 129 0.93

2 7 0.083 17 8.1 0.5 1 21 163 183 163 186 0.85

3 7 0.007 1.4 11.5 1.0 3 23 192 213 191 213 0.96

4 7 0.0064 1.3 11.6 0.2 1 19 221 239 221 242 0.95

5 7 1.7e-05 0.0035 19.7 0.3 1 21 247 267 247 268 0.96

6 7 0.019 3.8 10.2 2.9 1 20 280 299 280 301 0.94

7 7 0.3 62 6.4 0.6 1 23 317 340 317 340 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.00063	0.13	14.8	0.6	2	23	107	129	106	129	0.93
2	7	0.083	17	8.1	0.5	1	21	163	183	163	186	0.85
3	7	0.007	1.4	11.5	1.0	3	23	192	213	191	213	0.96
4	7	0.0064	1.3	11.6	0.2	1	19	221	239	221	242	0.95
5	7	1.7e-05	0.0035	19.7	0.3	1	21	247	267	247	268	0.96
6	7	0.019	3.8	10.2	2.9	1	20	280	299	280	301	0.94
7	7	0.3	62	6.4	0.6	1	23	317	340	317	340	0.91

Coding Sequence: ATGAACACAGAACAGTGTAGTATTTGTCTAGAAAAGTACTATTCAACTGTAAGTGTAGATGATTCAGATGAATATAATGTAAAGTGGTTTACAAAACTGCAATTCATTGTACCCGAATTGGAATGGCTTGAAGAGTATCAAATATGTGAATCTTGCAAGACACAACTGGAAAAAGCTTGGGGGTTTAAAAAACTTGTGTTAAATTTAGAAGCAGAACGAAGATTAAAATTGGAAAAGAGAGAAACATATCTCAATGAagaaaatatcgattttaaagataattgcgATATCGAATACTATTATGAAGAAAAGGGGATTAGTTGTGAGATATGTTCTACATTGTTTACAACCCAAACCCAACTTCAGCAACATAAATTGCAAATTCATAGCGAAGATTCTTTCTTTGAAAAAGCCCCACAGTATAACAATGGTTTAAAAGCACTTACTGAAAATGAGGACACCATAACAGCTAGAAATAGCATTATTTTTACGTGTTATGACTGTAGTATAgattttatcacaaaaaaagACTTACTTTTTCACGTTGAAAATGAACATGACCAATCAAATTTATGTGTAATATGTGAAAAATCGTGTCCAACTAAGACAATACTGCAAAATCACATGAGAGATGAACATAAGatagaaatatataaagaatacTCTTGTTCTTTTTGTCCTGTTAAATTTGAGTCGGAGGCGAAATTAACCAAACATGCCAGTCTATGTAGCTCTAAATTTCAGTGTAGCATATGTACACAAGTTTACAGCACTAAGAAGTTGTTAAACGCTCACattaaattatgcaaaaataagAAGAGAAGTGATAAGCTTTTACATCAATGTCATACTTGCAAGAACTTTTACACCACAGAGAAGAATTTAAATCTACACAAAATATGGTGTGTAAAAGAGAAACAAGAAAATGATCTAGGAGCAGTTGTTAATCATAACTGTGATATATGTGTTATCAAATTTGACTCAGTTGAGGAATATAATTCACATAATATATCAAAGCATAATCCACAAAAAAGAAATTAG
Protein Sequence: MNTEQCSICLEKYYSTVSVDDSDEYNVKWFTKLQFIVPELEWLEEYQICESCKTQLEKAWGFKKLVLNLEAERRLKLEKRETYLNEENIDFKDNCDIEYYYEEKGISCEICSTLFTTQTQLQQHKLQIHSEDSFFEKAPQYNNGLKALTENEDTITARNSIIFTCYDCSIDFITKKDLLFHVENEHDQSNLCVICEKSCPTKTILQNHMRDEHKIEIYKEYSCSFCPVKFESEAKLTKHASLCSSKFQCSICTQVYSTKKLLNAHIKLCKNKKRSDKLLHQCHTCKNFYTTEKNLNLHKIWCVKEKQENDLGAVVNHNCDICVIKFDSVEEYNSHNISKHNPQKRN

Sequence clustering based on sequence similarity using MMseqs2